Variation in the SLC16A1 and the ACOX1 Genes Is Associated with Gallop Racing Performance in Arabian Horses

Fontanel, Marie; Todd, Evelyn T.; Drabbe, Alize; Ropka‐Molik, Katarzyna; Stefaniuk‐Szmukier, Monika; Myćka, Grzegorz; Velie, Brandon D.

doi:10.1016/j.jevs.2020.103202

Cited by 7 publications

(5 citation statements)

References 25 publications

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“…One of the best characterised genes for racing performance in Arabian horses is the SLC16A1 gene encoding the solute carrier family 16 member 1 protein that catalyses the movement of lactate and pyruvate across the plasma membrane 8 , 9 , 102 . In humans, genetic variants in the gene are used to predict athletic performance, in particular high-intensity exercise, and power ability 103 , 104 .…”

Section: Resultsmentioning

confidence: 99%

“…Among track racing Arabians there is evidence of recent Thoroughbred crossbreeding, presumably for the introduction of speed, with some horses having up to 60% Thoroughbred ancestry 7 . Although considered a highly polygenic trait, sequence variants at several genes have been reported to be directly associated with performance traits in the Arabian breed [7][8][9][10] .…”

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confidence: 99%

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Common protein-coding variants influence the racing phenotype in galloping racehorse breeds

et al. 2022

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Selection for system-wide morphological, physiological, and metabolic adaptations has led to extreme athletic phenotypes among geographically diverse horse breeds. Here, we identify genes contributing to exercise adaptation in racehorses by applying genomics approaches for racing performance, an end-point athletic phenotype. Using an integrative genomics strategy to first combine population genomics results with skeletal muscle exercise and training transcriptomic data, followed by whole-genome resequencing of Asian horses, we identify protein-coding variants in genes of interest in galloping racehorse breeds (Arabian, Mongolian and Thoroughbred). A core set of genes, G6PC2, HDAC9, KTN1, MYLK2, NTM, SLC16A1 and SYNDIG1, with central roles in muscle, metabolism, and neurobiology, are key drivers of the racing phenotype. Although racing potential is a multifactorial trait, the genomic architecture shaping the common athletic phenotype in horse populations bred for racing provides evidence for the influence of protein-coding variants in fundamental exercise-relevant genes. Variation in these genes may therefore be exploited for genetic improvement of horse populations towards specific types of racing.

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Section: Resultsmentioning

confidence: 99%

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Common protein-coding variants influence the racing phenotype in galloping racehorse breeds

et al. 2022

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“…Several mutations are known to be associated with race distance fitness [9,10] and body composition [11] in Thoroughbreds. Additional candidate genes have been found in Arabians [12] and Quarter Horses [13]. However, the sporting use of horses covers more areas than just racing performance.…”

Section: Introductionmentioning

confidence: 99%

Identification of Differentially Expressed Genes after Endurance Runs in Karbadian Horses to Determine Candidates for Stress Indicators and Performance Capability

Reißmann,

Rajavel,

Kokov

et al. 2023

Genes

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RNA sequencing makes it possible to uncover genetic mechanisms that underlie certain performance traits. In order to gain a deeper insight into the genetic background and biological processes involved in endurance performance in horses, the changes in the gene expression profiles induced by endurance runs over long (70 km) and short (15 km) distances in the blood of Kabardian horses (Equus caballus) were analyzed. For the long-distance runs, we identified 1484 up- and 691 downregulated genes, while after short-distance runs, only 13 up- and 8 downregulated genes (FC > |1.5|; p < 0.05) were found. These differentially expressed genes (DEGs) are involved in processes and pathways that are primarily related to stress response (interleukin production, activation of inflammatory system) but also to metabolism (carbohydrate catabolic process, lipid biosynthesis, NADP metabolic process). The most important genes involved in these processes therefore represent good candidates for the monitoring and evaluation of the performance of horses in order to avoid excessive demands when endurance performance is required, like ACOD1, CCL5, CD40LG, FOS, IL1R2, IL20RA, and IL22RA2, on the one hand, and, on the other hand, for assessing the suitability of a horse for endurance races, like GATA2, GYG1, HIF1A, MOGAT1, PFKFB3, PLIN5, SIK1, and STBD1.

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“…Arabian horses originating from the Middle East are one of the world’s oldest breeds. They have been significantly influential in developing new horse breeds such as the “Thoroughbreds” in the modern world [ 6 , 7 ]. Thoroughbreds were developed in England for racing and jumping.…”

Section: Introductionmentioning

confidence: 99%

“…The Arabian horse breed, widely known primarily for its beautiful appearance and endurance, has been used to improve some characteristics of other horse breeds. [ 7 ]. Although the Arabian horse breed is still the most common worldwide, with a pedigree recorded in at least 82 countries, the number of American Quarter Horses is now more significant in absolute terms.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Random Regression Models with Different Order Legendre Polynomials for Genetic Parameter Estimation on Race Completion Speed of Arabian Horses

Önder

Şen

Piwczyński

et al. 2022

Animals

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This work aimed to compare the fitting performance of the random regression models applied to the different order orthogonal Legendre polynomials on the race completion speed (m/s) of Arabian racing horses. Legendre polynomial function for additive genetic, permanent environmental variances and heritability values with the L(2,2), L(2,3), L(3,2) and L(3,3) models (where L(i,j) means L(order of fit for additive genetic effects, order of fit for permanent environmental effects)) was estimated. A total of 233,491 race speed records (m/s) of Arabian horses were taken from the Jockey Club of Turkey between 2005 and 2016. The mean and standard deviation of heritability values were estimated as 0.294 ± 0.0746, 0.285 ± 0.0620, 0.302 ± 0.0767 and 0.290 ± 0.1018 for L(2,2), L(2,3), L(3,2), and L(3,3), respectively. The steady decreasing trend of permanent environmental variances for L(2,2) provided stationery for heritability values. According to Akaike information criterion (AIC) and Bayesian information criterion (BIC) values, the L(2,2) model could be reliably used to estimate heritability values for the racing speed of Arabian horses in the presence of repeated observations.

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Variation in the SLC16A1 and the ACOX1 Genes Is Associated with Gallop Racing Performance in Arabian Horses

Cited by 7 publications

References 25 publications

Common protein-coding variants influence the racing phenotype in galloping racehorse breeds

Common protein-coding variants influence the racing phenotype in galloping racehorse breeds

Identification of Differentially Expressed Genes after Endurance Runs in Karbadian Horses to Determine Candidates for Stress Indicators and Performance Capability

Comparison of Random Regression Models with Different Order Legendre Polynomials for Genetic Parameter Estimation on Race Completion Speed of Arabian Horses

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