Variation of immunological response in methotrexate-induced pneumonitis

Chikura, Batsi; Sathi, Navtej; Lane, Steven; Dawson, Julie

doi:10.1093/rheumatology/ken356

Cited by 40 publications

(36 citation statements)

References 40 publications

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“…Several studies have reported that RA-LD is associated with male gender, a history of smoking and seropositivity [1,[12][13][14][15]. Besides, environmental factors [16], drugs [17][18][19], and underlying diseases [4] may also contribute to the occurrence of RA-LD. However, in a few studies, changes in airways have been reported in early RA even in those who have never smoked, independent of seropositivity [9,20].…”

Section: Introductionmentioning

confidence: 99%

Association of Single Nucleotide Polymorphisms of PADI4 and HLA-DRB1 Alleles with Susceptibility to Rheumatoid Arthritis-Related Lung Diseases

Song

Kim

et al. 2016

Lung

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Section: Introductionmentioning

confidence: 99%

Association of Single Nucleotide Polymorphisms of PADI4 and HLA-DRB1 Alleles with Susceptibility to Rheumatoid Arthritis-Related Lung Diseases

Song

Kim

et al. 2016

Lung

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“…However, these drugs also often have adverse effects. For example, methotrexate is an anti-rheumatic drug that has been reported to increase the risk of interstitial pneumonia [5]. Infliximab, a molecular-targeted drug, was reported to have decreased its effect due to production of neutralizing antibody [4].…”

Section: Discussionmentioning

confidence: 99%

Effects of the Sri Lankan medicinal plant, Salacia reticulata, in rheumatoid arthritis

et al. 2009

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Salacia reticulata is a native plant of Sri Lanka. In the traditional medicine of Sri Lanka and India, Salacia reticulata bark is considered orally effective in the treatment of rheumatism, gonorrhea, skin disease and diabetes. We have investigated, both in vivo and in vitro, whether the leaf of Salacia reticulata (SRL) can ameliorate collagen antibody-induced arthritis (CAIA) in mice as the rheumatoid arthritis (RA) model. The mice were fed a lard containing chow diet (AIN-93G) or the same diet containing 1% (w/w) SRL powder. All mice were bred for 23 days. On day 7 or 14 after LPS injection, mice were killed, and tissue and blood samples were collected. Histological analysis was performed, and serum levels of inflammatory mediators and the mRNA levels of inflammation-related genes and osteoclast-related genes were measured. SRL treatment ameliorated the rapid initial paw swelling, inflammatory cells infiltration, skeletal tissues damage, osteoclast activation and the mRNA levels for osteoclast-related genes compared with the CAIA mice. However, the serum and mRNA levels of inflammatory mediators did not differ between the CAIA mice and the SRL-treated mice. SRL might reduce the inflammatory cells induction and skeletal tissue degradation by CAIA by the regulating osteoclastogenesis.

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“…Mortality is low. 31 Claire et al compared BAL fluid cell counts of MTXpneumonitis cases with patients on MTX without MTXtoxicity and normal healthy controls. They noted severe lymphocytic alveolitis in MTX-pulmonary toxicity compared with the other two groups.…”

Section: Mechanism Of Pulmonary Toxicitymentioning

confidence: 99%

“…9 Similar case has been reported by Van der Veen et al 35 A recent study from Egypt has reported deterioration of lung function on methotrexate. 31 Masayuki et al studied induction of pulmonary fibrosis by methotrexate in lungs of mice both in vivo and in vitro. They could induce alveolar epithelialecapillary basement membrane changes followed by proliferation and recruitment of myofibroblasts and collagen deposition.…”

Section: Mechanism Of Pulmonary Toxicitymentioning

confidence: 99%

Methotrexate induced pneumonitis

Nagaraj

Joshi

2012

Indian Journal of Rheumatology

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Methotrexate induced pneumonitis (MTX-P) is an uncommon, but potentially serious and life-threatening adverse event. The dose, duration of treatment and route of administration of methotrexate bear no relationship to MTX-P. Many risk factors have been studied but no definitive risk factor is identified. Pre-existing pulmonary disease may be associated with increased risk of MTX-P. Several sets of criteria have been proposed for diagnosis of MTX-P but none are validated. Diagnosis is mainly clinical and requires a high degree of suspicion. Treatment is mainly supportive along with discontinuation of methotrexate. Most patients recover. Mortality up to 17% has been reported in literature. Reintroduction of methotrexate after recovering from MTX-P is generally avoided. This article focuses on the epidemiology, clinical presentation, pathology, laboratory features and management of MTX-P.

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Variation of immunological response in methotrexate-induced pneumonitis

Cited by 40 publications

References 40 publications

Association of Single Nucleotide Polymorphisms of PADI4 and HLA-DRB1 Alleles with Susceptibility to Rheumatoid Arthritis-Related Lung Diseases

Association of Single Nucleotide Polymorphisms of PADI4 and HLA-DRB1 Alleles with Susceptibility to Rheumatoid Arthritis-Related Lung Diseases

Effects of the Sri Lankan medicinal plant, Salacia reticulata, in rheumatoid arthritis

Methotrexate induced pneumonitis

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