2015
DOI: 10.1016/j.gene.2015.06.010
|View full text |Cite
|
Sign up to set email alerts
|

Variation within three apoptosis associated genes as potential risk factors for Achilles tendinopathy in a British based case–control cohort

Abstract: Variation within three apoptosis associated genes as potential risk factors for Achilles tendinopathy in a British based casecontrol cohort. Gene. 571(2), pp. 167171. 03781119.It is advisable to refer to the publisher's version if you intend to cite from this work. Achilles tendon pathology (ATP) is a degenerative condition which exhibits excessive 30 tenocyte apoptosis. Tumour necrosis factor receptor 1 (TNFR1), caspase-3 (CASP3) and 31 caspase-8 (CASP8) are important regulators of apoptosis. To date, the eff… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
11
0

Year Published

2017
2017
2020
2020

Publication Types

Select...
7

Relationship

1
6

Authors

Journals

citations
Cited by 10 publications
(11 citation statements)
references
References 27 publications
0
11
0
Order By: Relevance
“…46,61,155 The relationship between genotype, abnormal collagen, mechanical stress, and symptom presentation is multifactorial and not well understood. 11,72,156,163,172…”
Section: Pathoanatomical Features 2018 Summary and Updatementioning
confidence: 99%
“…46,61,155 The relationship between genotype, abnormal collagen, mechanical stress, and symptom presentation is multifactorial and not well understood. 11,72,156,163,172…”
Section: Pathoanatomical Features 2018 Summary and Updatementioning
confidence: 99%
“…All included articles were published in English and had a mixed population of physically active people. Of the 22 included studies, 17 studies recruited runners and people who participated in recreational sports such as squash [2339]. A single epidemiology study involved military personnel [40], while one study included elderly people involved in tennis, jogging and speed walking [41].…”
Section: Resultsmentioning
confidence: 99%
“…The results did not show any significant association between Achilles tendinopathy, the investigated polymorphisms and CNV. This is possibly due to the study limitations, such as a relatively small sample size and a possible additional degree of error due to the rounding of copy number data into discrete calls, or may indicate that there is no association between these CNVs and Achilles tendinopathy [39]. …”
Section: Discussionmentioning
confidence: 99%
“…It must be noted that the rs1800012 variant was previously genotyped in the SA‐Achilles tendon injury cohort and the result presented by Posthumus et al 15 For this reason, this data was only included for the combined analyses. The UK‐Achilles tendon injury cohort consisted of 130 apparently healthy asymptomatic control participants (UK‐CON), 87 participants with chronic Achilles UK‐TEN and 25 participants with acute UK‐ATR 24 . The single ACL rupture cohort consisted of 232 apparently healthy asymptomatic control participants (SA‐CON ACL ) and 233 participants with clinically diagnosed ACL ruptures (SA‐ACL).…”
Section: Methodsmentioning
confidence: 99%