Variations in caffeine and chlorogenic acid contents of coffees: what are we drinking?

Ludwig, Iziar A.; Mena, Pedro; Calani, Luca; Cid, Concepción; Rio, Daniele Del; Lean, Michael E. J.; Crozier, Alan

doi:10.1039/c4fo00290c

Cited by 189 publications

(177 citation statements)

References 28 publications

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“…Dose response and tolerance to regular consumption vary between individuals; so, for some people, even a single cup may cause sleeplessness with a racing mind, while for others, drinking ten times this amount can still be pleasant and not interfere with sleep [6]. Caffeine has a half-life of approximately 4-6 h, with a plasma peak time concentration following it ingestion between 30-60 minutes (average 40) [7].…”

Section: Introductionmentioning

confidence: 99%

“…It mainly acts upon the central nervous system, with widely known physiological and psychological effects (increased alertness, enhanced vigilance, reduced fatigue) [1][2][3][4][5][6]. All its effects are through the antagonism of the A1 and A2 subtypes of the adenosine receptor, potentiating the effects of sympathetic nervous system stimulation [6].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Caffeine Intake on Retinal Microsurgical Performance

Arriola-López¹,

Morales-Cantón²,

García-Aguirre³

et al. 2016

J Clin Exp Ophthalmol

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Objective: To assess the effects of prior caffeine intake on tremor control and internal limiting membrane peeling proficiency of experienced retinal surgeons using a microsurgical simulator. Methods:Experienced vitreoretinal surgeons were included. On two separate days, each subject underwent a test on a level 4 anti-tremor test and internal limiting membrane peeling test on a microsurgical simulator (Eye-Si/ Series 199, VRMagic, Sofware 2.9, Mannheim, Germany) first with no caffeine intake and after 40 minutes of taking an oral dose of caffeine (200 mg and 400 mg). Each subject underwent blood pressure and heart rate measurements before and 40 min after caffeine intake. The same technician measured both surgical performances.Results: Mean age was 46.4 ± 10.1 years. All subjects were male. The mean anti-tremor results were: baseline scores 61.2 ± 19.15, 200 mg 61.6 ± 12.63 and 400 mg 75.4 ± 15.09. The mean internal limiting membrane peeling results were: baseline score 55.9 ± 5.46, 200 mg 54.8 ± 10.05 and 400 mg 62.6 ± 9.63. Blood pressure and heart rate remained stable. After consumption of higher doses of caffeine some adverse effects were reported such as headache and a transient episode of anxiety. Conclusion:Caffeine consumption prior to surgery is discouraged by microsurgeons due to potential adverse effects. Our results showed no significant change on the surgical ability after 200 and 400 mg of oral caffeine. There was a non-significant improvement on the overall score after 400 mg.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Caffeine Intake on Retinal Microsurgical Performance

Arriola-López¹,

Morales-Cantón²,

García-Aguirre³

et al. 2016

J Clin Exp Ophthalmol

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“…[6][7][8] Because of these many positive influences on human body, since the middle of the 19 th century, when the first references about CGAs appeared, there have been a high amount of articles dealing with extraction and detection techniques of CGAs or studying their influence on human health. CGAs have been observed and isolated in many plant materials such as coffee 9 , apple 10 , tomato, papaya 11 , sweet potato 12 , prune 13 , pear 14 , cabbage 15 , yacon 16 , burdock 17 , cherry 18 , apricot 19 , orange 20 , etc. Coffee beans are undoubtedly the most common observed matrix because coffee is the main source of CGAs.…”

Section: Introductionmentioning

confidence: 99%

Unremitting Problems With Chlorogenic Acid Nomenclature: A Review

Kremr¹,

Bajer²,

Bajerová³

et al. 2016

Química Nova

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Recebido em 08/12/2015; aceito em 12/01/2016; publicado na web em 12/04/2016 This paper summarizes a problematic nomenclature of isomers belonging to chlorogenic acid family since its first occurrence until present. During decades, there have been a high number of articles dealing with the family. Unfortunately, researchers who want to get knowledge about this topic may be strongly confused after reading a few articles. Due to gradual discoveries and isolations of the individual isomers from plenty of matrices and because of the changing system of terminology after these discoveries, discrepancies among articles are common. The cause of this confusion is that the main compound of the family, 5-caffeoylquinic acid (also wellknown as chlorogenic acid), was truly called as 3-caffeoylquinic acid before 1976, when new rules for nomenclature were published. Many researchers and also chemicals suppliers, however, keep using the "pre-IUPAC" nomenclature and wrongly call 3-caffeoylquinic acid as chlorogenic acid, the main substituent of the family. Despite there have been some works struggling with this issue, the problem is still appearing. Therefore, the present work was written.

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“…Hydroxyhydroquinone is a compound that is generated from the roasting of coffee beans [28]. Direct measurements of commercially available brewed coffee showed that less than 200 mg chlorogenic acids is generally contained in one serving [37]. The beverages were manufactured industrially (Kao Co. Tokyo, Japan) and were taste-and flavor-matched (coffee-flavored).…”

Section: Test Beveragesmentioning

confidence: 99%

Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension

et al. 2018

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Purpose The purpose of this study was to evaluate acute effects of coffee with a high content of chlorogenic acids and different hydroxyhydroquinone contents on postprandial endothelial dysfunction. Methods This was a single-blind, randomized, placebo-controlled, crossover-within-subject clinical trial. A total of 37 patients with borderline or stage 1 hypertension were randomized to two study groups. The participants consumed a test meal with a single intake of the test coffee. Subjects in the Study 1 group were randomized to single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone or coffee with a high content of chlorogenic acids and a high content of hydroxyhydroquinone with crossover. Subjects in the Study 2 group were randomized to single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone or placebo coffee with crossover. Endothelial function assessed by flow-mediated vasodilation and plasma concentration of 8-isoprostanes were measured at baseline and at 1 and 2 h after coffee intake. Results Compared with baseline values, single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone, but not coffee with a high content of chlorogenic acids and high content of hydroxyhydroquinone or placebo coffee, significantly improved postprandial flow-mediated vasodilation and decreased circulating 8-isoprostane levels. Conclusions These findings suggest that a single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone is effective for improving postprandial endothelial dysfunction.

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Variations in caffeine and chlorogenic acid contents of coffees: what are we drinking?

Abstract: This paper reports on the wide variations in the caffeine and chlorogenic acid contents of coffees purchased in Scotland, Spain and Italy. Image © Shutterstock.

Cited by 189 publications

References 28 publications

Effect of Caffeine Intake on Retinal Microsurgical Performance

Effect of Caffeine Intake on Retinal Microsurgical Performance

Unremitting Problems With Chlorogenic Acid Nomenclature: A Review

Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension

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