Variations in glucocorticoid levels within the physiological range affect plasma leptin levels

Elimam, Amira; Knutsson, Urban; Brönnegård, Mikael; Stierna, Pontus; Albertsson‐Wikland, Kerstin; Marcus, Claude

doi:10.1530/eje.0.1390615

Cited by 59 publications

(31 citation statements)

References 42 publications

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“…The findings in this study support our previous report that glucocorticoids within the physiological range upregulate plasma leptin (13), as this was also noticed following the ingestion of a total of 0.4 mg DEX in the volunteers eating twice a day. In contrast, DEX did not increase leptin in those fasting for 48 h when compared with the control group.…”

Section: A Elimam and C Marcussupporting

confidence: 92%

“…In most studies, exogenous glucocorticoids are reported to upregulate leptin (11,13), but it has been questioned if the effect is limited to pharmacological dosing (31). The findings in this study support our previous report that glucocorticoids within the physiological range upregulate plasma leptin (13), as this was also noticed following the ingestion of a total of 0.4 mg DEX in the volunteers eating twice a day.…”

Section: A Elimam and C Marcussupporting

confidence: 86%

“…We have used this dose in a previous study (13), where in young healthy men, it increased serum leptin by 50% within 2 weeks.…”

Section: The Dex Dosementioning

confidence: 99%

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Meal timing, fasting and glucocorticoids interplay in serum leptin concentrations and diurnal profile

Elimam

Marcus²

2002

European Journal of Endocrinology

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Background: In a previous study, we reported a 4-fold increase in serum leptin following total parenteral nutrition given after surgery. We hypothesised that the perioperative fasting and stress contributed to this, possibly mediated by increased serum insulin and cortisol. Objective: To test the hypothesis that fasting, in combination with glucocorticoids, sensitises the leptin response to subsequent energy intake. Design: Healthy volunteers were randomised into two groups, one group received dexamethasone (DEX), 0.1 mg twice daily for 3 days, while the other group served as a control. Each group was then subdivided into two feeding protocols. Protocol 1, where a standard meal was given at 0, 24, 36 and 48 h and protocol 2 where the same meal was given at 0 and 48 h. Blood samples were drawn before, as well as every other hour during the study period for determination of serum leptin, insulin, glucose and cortisol concentrations. Results: In all groups serum leptin increased significantly following each meal ðP , 0:01Þ: The rise in serum leptin in response to the standard meal was higher when the meal was taken in the evening ðP , 0:001Þ or following longer duration of fasting ðP , 0:02Þ: In those fasting for 48 h, leptin decreased by 60% and showed no diurnal variation. DEX intake increased leptin concentrations in those fasting for short periods ðP , 0:02Þ but not for 48 h. Conclusions: Long durations of fasting sensitise the response of leptin to subsequent energy intake and abolish the DEX-induced upregulation of leptin. Meal timing is an important factor determining the leptin diurnal rhythm, but other factors must contribute since the leptin response to a standard meal taken in the evening was greater than to the same meal taken in the morning.

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Section: A Elimam and C Marcussupporting

confidence: 92%

Section: A Elimam and C Marcussupporting

confidence: 86%

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Meal timing, fasting and glucocorticoids interplay in serum leptin concentrations and diurnal profile

Elimam

Marcus²

2002

European Journal of Endocrinology

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“…Glucocorticoids are potent stimulators of leptin secretion [13, 14, 15, 16, 17, 18, 19], and there is a reciprocal temporal relationship between circulating leptin and glucocorticoids [5, 20, 21]. The nocturnal increase in leptin, when compared as 24-hour secretory profiles, closely resembles the early morning rise of cortisol [4].…”

Section: Introductionmentioning

confidence: 99%

Glucocorticoid Effects on the Diurnal Rhythm of Circulating Leptin Levels

Nishiyama

Makino

Suemaru³

et al. 2000

Horm Res Paediatr

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It is known that circulating leptin shows diurnal variation with a nocturnal rise; however, the mechanisms generating this rhythm have not been fully elucidated. Glucocorticoids are a potent stimulator of leptin secretion, and there is a reciprocal relationship between circulating leptin and glucocorticoid levels. We hypothesized that glucocorticoids could modulate the diurnal rhythm of circulating leptin. We therefore explored the diurnal variation of leptin under situations in which subjects showed no or some shift of glucocorticoid diurnal rhythm, such as prednisolone-administered humans, and adrenalectomized and corticosterone-replaced (ADX+B) rats. The peak level of plasma cortisol immunoreactivity was shifted from early morning to noon by prednisolone administration. The nocturnal increment of plasma leptin in prednisolone-administered patients (71.2 ± 14.2% from 08:00 h value) was significantly greater than that in normal volunteers (12.2 ± 7.5% from 08:00 h value), but the timing of nadir and the peak of plasma leptin was not shifted. In normal rats, the plasma concentration of leptin showed the diurnal rhythm with the bottom at 16:00 h and the top between midnight and early morning. The amplitude of leptin diurnal rhythm was significantly reduced in ADX+B rats (08:00 h: 3.0 ± 0.2, 16:00 h: 2.7 ± 0.2, 00:00 h; 3.7 ± 0.2 ng/ml) compared with sham operated rats (08:00 h: 3.0 ± 0.2, 16:00 h 2.2 ± 0.2, 00:00 h: 4.7 ± 0.4 ng/ml); but ADX+B rats still retained similar timing of nadir and the peak of plasma leptin as observed in sham rats. These results indicate that glucocorticoids enhance the amplitude of leptin diurnal rhythm, and are consistent with previous findings showing that glucocorticoids increase leptin secretion. Glucocorticoids appear to play modulatory, but not essential roles in generating leptin diurnal rhythm.

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“…17 Kronik glukokortikoid uygulamaları, kültüre edilmiş adipositlerde ve in vivo ortamda leptin sentezini artırır. 18 Akut enfeksiyon sırasında, endotoksine ve proinflamatuar sitokinlere yanıt olarak leptin sentezi artar. 17 Büyüme hormonu eksikliğinde, muhtemelen vücut yağı artışının sonucu olarak leptin seviyesi artar.…”

Section: Lepti̇n Hormonu üReti̇mi̇ni̇ Etki̇leyen Faktörlerunclassified

Factors Affecting Blood Leptin, Ghrelin and Adiponectin Levels:Review

Altıner¹,

Şahin²,

Bilal³

et al. 2016

Turkiye Klinikleri J Vet Sci

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Kan Leptin, Grelin ve Adiponektin Düzeylerini Etkileyen Faktörler Ö ÖZ ZE ET T Bazı gelişmiş ve gelişmekte olan ülkelerde obezite önemli bir sağlık sorunudur ve Tip 2 diyabet, kardiyovasküler hastalıklar, zayıflamış immünite, eklem rahatsızlıkları gibi birçok sağlık sorununa zemin hazırlar. Adipoz doku nöroendokrin, otonomik ve immün fonksiyonların kontrolü kadar enerji dengesinde de aktif bir rol oynar ve leptin, adiponektin ile resistin gibi adipokinleri sentezler ve salgı-lar. Obezite, gıda alımı, glukoz, insülin, kortizol, endotoksinler ve sitokinler serum leptin düzeylerini artırmaktadırlar. Gıda alımı arttığında leptin salgısı artar ve insülin direnci gelişir. Hiperleptineminin metabolik sendromun bir komponenti olduğu da bilinmektedir. Grelin, iştahı açan ve glukoz oksidasyonu ile lipogenezi uyaran bir mide peptididir. İnsanlarda ve hayvanlarda yiyecek alımını ve yağlan-mayı artırır. Düşük protein diyeti ile beslenmede grelin düzeyleri artar, yüksek yağlı diyetle beslenmede ise düşer. Adiponektin, yağ hücrelerinden dolaşıma bırakılan çok fonksiyonlu bir peptit hormondur. Bu adipokin antiinflamatuvar, antiaterojenik, antidiyabetik ve antitümör özelliklere sahiptir ve çeşitli kalp ile karaciğer hasarlarına karşı organizmayı korumaktadır. Dolaşımdaki düzeyleri obezitede düşüktür ve kilo kaybı ile birlikte artar. Adiponektin, obezite ile ilişkili patolojilerin önlenmesi ve tedavisi için yeni bir hedef olabilir. Derlemenin amacı güncel bir sağlık sorunu olan obezite ile ilişkili ve enerji dengesine aracılık eden peptitler leptin, grelin ve adiponektinin kan düzeylerinin azalması veya artmasına neden olan faktörleri birarada incelemektir.A An na ah ht ta ar r K Ke el li im me el le er r: : Obezite; leptin; grelin; adiponektin A AB BS ST TR RA AC CT T Obesity is a major health problem in some developed and developing countries, and predisposes to many health problems such as type 2 diabetes mellitus, cardiovascular diseases, weakened immunity and joint diseases. Adipose tissue plays an active role in energy balance as well as control of the neuroendocrine, autonomic and immune functions, and synthesizes and secretes adipokines such as leptin, adiponectin and resistin. Obesity, food intake, glucose, insulin, cortisol, endotoxins and cytokines increase serum leptin levels. The increased food intake increases the leptin secretion, and insulin resistance occurs. Hyperleptinemia is also known to be a component of the metabolic syndrome. Ghrelin is a stomach peptide stimulating the lipogenesis, the oxidation of glucose and the appetite. Ghrelin increases food intake and lubrication in humans and animals. Low protein diet increases the ghrelin levels, and high fat diet decreases them. Adiponectin is a multifunctional peptide hormone that is released from fat cells into the circulation. This adipokine has antiinflammatory, antiatherogenic, antidiabetic and antitumor properties and protects the organism against various heart and liver damages. The circulating levels of adiponectin is low in obesity, and increase with wei...

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Variations in glucocorticoid levels within the physiological range affect plasma leptin levels

Cited by 59 publications

References 42 publications

Meal timing, fasting and glucocorticoids interplay in serum leptin concentrations and diurnal profile

Meal timing, fasting and glucocorticoids interplay in serum leptin concentrations and diurnal profile

Glucocorticoid Effects on the Diurnal Rhythm of Circulating Leptin Levels

Factors Affecting Blood Leptin, Ghrelin and Adiponectin Levels:Review

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