Variations in inflammation-related genes may be associated with childhood febrile seizure susceptibility

Emsley, Hedley; Appleton, Richard; Whitmore, Catherine; Jury, Francine; Lamb, Janine A.; Martin, Joanne E.; Ollier, William; Morandière, Katherine Potier de la; Southern, Kevin W; Allan, Stuart M.

doi:10.1016/j.seizure.2014.03.006

Cited by 19 publications

(8 citation statements)

References 24 publications

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“…Khoshdel et al found a significant correlation between genotype distribution of G-308A and complex FS in Iranian patients, but there was no correlation between TNF-α polymorphisms at positions of −308A, and 850T and predisposition to simple FS [4]. Emsley et al found no significant association of TNF-α SNPs, but significant result was for missense SNP rs208294 in P2X7R (purinergic receptor P2X7) [41]. Also, Chou et al demonstrated that IL-1 receptor antagonist allele 1 homozygote was more frequent in patients with FS than in healthy controls, but no significant difference was evident in the distribution of allele frequencies of the IL-1B promoter, IL-1B exon 5, IL-6 promoter, IL-8, IL-10, or the TNF-α gene polymorphism [42].…”

Section: Discussionmentioning

confidence: 99%

Single nucleotide polymorphisms of TNF-Α gene in febrile seizures

Zare-Shahabadi

Ashrafi

Shahrokhi

et al. 2015

Journal of the Neurological Sciences

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Section: Discussionmentioning

confidence: 99%

Single nucleotide polymorphisms of TNF-Α gene in febrile seizures

Zare-Shahabadi

Ashrafi

Shahrokhi

et al. 2015

Journal of the Neurological Sciences

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“…Some studies showed that MPVs levels were increased due to decreased platelet count during acute infection. Therefore platelets play an important role during infection and inflammation 28,29 . Some other studies suggests that inflammation, which is intrinsic to the fever response, is involved in the generation of FS 15 .…”

Section: Discussionmentioning

confidence: 99%

Çocuklarda trombosit belirteçleri ve febril konvülziyon arasındaki ilişki

Özkale

Erol

Özkale

et al. 2016

Cukurova Medical Journal (Çukurova Üniversitesi Tıp Fakültesi Dergisi)

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AbstractÖz Purpose: Febrile seizures (FS) are the most common type of seizures in children.The aim of this study was to evaluate the relationship between platelet indices and FS in children. Materials and Methods:This prospective study included 40 children who presented with FS and 30 controls who presented with febrile illnesses without seizures. Complete blood counts, including platelet count (PC), mean platelet volume (MPV), and platelet distribution width (PDW) from both groups within 1 hour of FS and 1 month later were obtained. Results: We found that the MPV and PDW within 1 hour of seizure in children with complex FS group was higher than simple FS group while there was no significant difference in MPV and PDW between patients in the simple and complex FS groups at 1 month. The mean PC was not significantly different between simple and complex FS groups; but, we found that the mean PC in the complex FS group was slightly lower than simple FS group.There was a moderate significant positive correlation between MPV and PDW in children with FS while there was a moderate significant negative correlation between PC and MPV, PDW for FS . Conclusion: Our findings suggest that the increasing platelet turnover in complex FS group causes a slightly decrease in the PC, an significantly increase of MPV and PDW values indicating that these parameters may play an important role in predicting the severity of FS in children at diagnosis.

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“…Inflammatory response components, such as those involved in the interleukin 1 (IL-1) system, have been suspected to play a role in FS [Gatti et al, 2002]. Recent reports indicate that certain SNPs in genes that encode other inflammation-related molecules, such as IL-6 [Shahrokhi et al, 2014], IL-6 receptor, prostaglandin E receptor 3, purinergic receptor P2X7, or TLR-4, may be involved in the pathogenesis of FS [Emsley et al, 2014].…”

Section: Febrile Seizuresmentioning

confidence: 99%

Seizures and Epilepsies due to Channelopathies and Neurotransmitter Receptor Dysfunction: A Parallel between Genetic and Immune Aspects

Lascano¹,

Korff

Picard³

2016

Mol Syndromol

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Despite intensive research activity leading to many important discoveries, the pathophysiological mechanisms underlying seizures and epilepsy remain poorly understood. An important number of specific gene defects have been related to various forms of epilepsies, and autoimmunity and epilepsy have been associated for a long time. Certain central nervous system proteins have been involved in epilepsy or acute neurological diseases with seizures either due to underlying gene defects or immune dysfunction. Here, we focus on 2 of them that have been the object of particular attention and in-depth research over the past years: the N-methyl-D-aspartate receptor and the leucin-rich glioma-inactivated protein 1 (LGI1). We also describe illustrative examples of situations in which genetics and immunology meet in the complex pathways that underlie seizures and epilepsy.

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Variations in inflammation-related genes may be associated with childhood febrile seizure susceptibility

Abstract: Genetic variants in inflammation-related genes, specifically purinergic receptor P2X7, may be involved in susceptibility to childhood-onset febrile seizures.

Cited by 19 publications

References 24 publications

Single nucleotide polymorphisms of TNF-Α gene in febrile seizures

Single nucleotide polymorphisms of TNF-Α gene in febrile seizures

Çocuklarda trombosit belirteçleri ve febril konvülziyon arasındaki ilişki

Seizures and Epilepsies due to Channelopathies and Neurotransmitter Receptor Dysfunction: A Parallel between Genetic and Immune Aspects

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