Variations in Plasma Magnesium and Potassium in Epilepsy

Hirschfelder, Arthur D.; Haury, Victor G.

doi:10.3181/00379727-33-8241p

Experimental Biology and Medicine

1935

DOI: 10.3181/00379727-33-8241p

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Variations in Plasma Magnesium and Potassium in Epilepsy

Arthur D. Hirschfelder¹,

Victor G. Haury²

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1944

1965

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Cited by 4 publications

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“…(Submitted for publication December 12, 1956; accepted April 11, 1957) Tissue analyses are of special importance in regard to the meager information available today concerning the role of magnesium in disease. Prior investigations of the concentration of serum magnesium have revealed modest fluctuations unassociated with any clear-cut, consistent, clinical syndromes (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). Balance studies (12)(13)(14)(15) have been hampered by the lack of low magnesium diets with the result that fluctuations in the balance have been obscured by an excessive magnesium intake and excretion.…”

mentioning

confidence: 99%

Skeletal Muscle Analyses in Health and in Certain Metabolic Disorders. I. The Method of Analysis and the Values in Normal Muscle1

Barnes¹,

Gordon²,

Cope³

1957

J. Clin. Invest.

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Tissue analyses are of special importance in regard to the meager information available today concerning the role of magnesium in disease. Prior investigations of the concentration of serum magnesium have revealed modest fluctuations unassociated with any clear-cut, consistent, clinical syndromes (1-11). Balance studies (12)(13)(14)(15) have been hampered by the lack of low magnesium diets with the result that fluctuations in the balance have been obscured by an excessive magnesium intake and excretion. This mineral is located almost exclusively in the cells or in the skeleton, and calculations based on a standard reference (16) 114-198. protoplasm, because of the accumulated information concerning its composition, and because of its availability at almost any operation.Definition of the intra-and extracellular spaces: A biochemical dissection. In the absence of an infallible technique for distinguishing between the intracellular phase and extracellular phase we have accepted the chloride space as an approximation of the extracellular space. It is well recognized that in diseased states where chloride ions may penetrate into the muscle fiber cell, the extracellular space -will be falsely enlarged. However, the chloride space still remains a most reasonable and practical means of correcting for the extracellular components to permit calculation by difference of the intracellular components. The evidence for the extracellular location of the chloride ion and for the proportionality of its total mass to the extracellular space has been recently reviewed (19).Bases of reference in expressing the concentrations of the muscle components. In tissue analyses advantages exist in expressing the results in terms of more than one reference base. Changes in the concentrations of the components in relation to one base might not appear in relating the concentrations to another due to a concomitant shift of the second base. Other considerations in the selection of a reference base are the effects of analytical variations in its determination which would cause fluctuations devoid of any biological significance and the natural variation of a reference base which should be as restricted as possible to minimize the confusion this would introduce into the interpretations. These independent characteristics may be assessed by statistical techniques outlined below.The reference base of intracellular water introduced by Hastings and Eichelberger (20) has been justified by water being the most plentiful constituent of tissues and by the success achieved in unfolding the properties of blood as a physiochemical system approximating a simple aqueous solution. More recently the use of non-collagen nitrogen (NCN), proposed by Lilienthal, Zierler, Folk, Buka, and Riley (21), as a reference base has the advantage of relating the intracellular components to a standard that is independent of any assumptions that the use of the chloride space entails in the calculation of the intracellular water. The non-collagen nitrogen, which is defined as...

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mentioning

confidence: 99%

Skeletal Muscle Analyses in Health and in Certain Metabolic Disorders. I. The Method of Analysis and the Values in Normal Muscle1

Barnes¹,

Gordon²,

Cope³

1957

J. Clin. Invest.

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Nutritional Dermatoses in the Rat

Sullivan¹,

Evans²

1944

Arch Derm Syphilol

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The Requirement of Magnesium by the Normal Adult

Seelig

1964

The American Journal of Clinical Nutrition

211

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I T IS hoped that Perspectives in Nutrition will review the literature selectively, interpret it moderately and present a spectrum of ideas that will serve as a continual stimulation to nutritional research applied to medical problems. M AGNESIUM has been accepted as an essential nutrient for the rat since 1932 when Kruse, Orent and McCollum 1 induced an acute magnesium deficiency syndrome in rats. The characteristics of magnesium deficiency were then studied in rats and in other laboratory animals by these investigators, 2-e and byGreenberg,T-10 Tuftsetal.u • 12 and Watchorn and McCance. u •In the past fifteen to twenty years, the early work on the magnesium deficiency syndrome has been verified and interrelationships of magnesium with other dietary • factors have been elucidated. The systems affected in the acute deficiency state are primarily neuromuscular, cardiovascular and renal. Hyperirritability terminating in convulsions, hyperemia, vasodilation and trophic changes in the skin are initial manifestations of acute magnesium deficiency. Calcinosis of heart, muscle and kidney occur later. During the 1930's and early in the war years, there was a fliiriy of interest in the possibility that magnesium depletion might play a role, in both man and farm animals, in conditions characterized by convulsions or by less severe manifestations of neuromuscular irritability. Haury and Hirschfelderu-18 correlated low plasma levels of magnesium with several clini-From the

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Variations in Plasma Magnesium and Potassium in Epilepsy

Cited by 4 publications

References 0 publications

Skeletal Muscle Analyses in Health and in Certain Metabolic Disorders. I. The Method of Analysis and the Values in Normal Muscle1

Skeletal Muscle Analyses in Health and in Certain Metabolic Disorders. I. The Method of Analysis and the Values in Normal Muscle1

Nutritional Dermatoses in the Rat

The Requirement of Magnesium by the Normal Adult

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