Variations in Predicted Regional Lung Deposition of Salbutamol Sulphate Between 19 Nebulizer Types

Finlay, Warren H.; Stapleton, K.W.; Zuberbuhler, Peter

doi:10.1089/jam.1998.11.65

Cited by 33 publications

(30 citation statements)

References 26 publications

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“…For both pMDIs and DPIs, it is preferable to perform in vitro experiments in realistic or idealized mouth-throat geometries (21) in order to estimate in vivo lung doses for a given device/formulation combination. For nebulizers, where fine droplets are well entrained in the inhaled airflow, deposition correlations and models tend to be more reliable, (22) provided hygroscopic behavior of the nebulized aerosol is included in the model, or may be safely neglected. (23) Regional lung deposition Many inhaled therapies are developed under the assumption that, in addition to the total dose delivered to the lungs, the regional deposition pattern within the lungs is an important determinant of efficacy.…”

Section: Targeting Approachesmentioning

confidence: 99%

Bridging the Gap Between Science and Clinical Efficacy: Physiology, Imaging, and Modeling of Aerosols in the Lung

Darquenne

Fleming

Katz

et al. 2016

Journal of Aerosol Medicine and Pulmonary Drug Delivery

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Development of a new drug for the treatment of lung disease is a complex and time consuming process involving numerous disciplines of basic and applied sciences. During the 2015 Congress of the International Society for Aerosols in Medicine, a group of experts including aerosol scientists, physiologists, modelers, imagers, and clinicians participated in a workshop aiming at bridging the gap between basic research and clinical efficacy of inhaled drugs. This publication summarizes the current consensus on the topic. It begins with a short description of basic concepts of aerosol transport and a discussion on targeting strategies of inhaled aerosols to the lungs. It is followed by a description of both computational and biological lung models, and the use of imaging techniques to determine aerosol deposition distribution (ADD) in the lung. Finally, the importance of ADD to clinical efficacy is discussed. Several gaps were identified between basic science and clinical efficacy. One gap between scientific research aimed at predicting, controlling, and measuring ADD and the clinical use of inhaled aerosols is the considerable challenge of obtaining, in a single study, accurate information describing the optimal lung regions to be targeted, the effectiveness of targeting determined from ADD, and some measure of the drug's effectiveness. Other identified gaps were the language and methodology barriers that exist among disciplines, along with the significant regulatory hurdles that need to be overcome for novel drugs and/or therapies to reach the marketplace and benefit the patient. Despite these gaps, much progress has been made in recent years to improve clinical efficacy of inhaled drugs. Also, the recent efforts by many funding agencies and industry to support multidisciplinary networks including basic science researchers, R&D scientists, and clinicians will go a long way to further reduce the gap between science and clinical efficacy.

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Section: Targeting Approachesmentioning

confidence: 99%

Bridging the Gap Between Science and Clinical Efficacy: Physiology, Imaging, and Modeling of Aerosols in the Lung

Darquenne

Fleming

Katz

et al. 2016

Journal of Aerosol Medicine and Pulmonary Drug Delivery

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“…Less affordable, but more compact, ultrasonic nebulizers find widespread use in many clinical settings. Finlay, Stapleton & Zuberbuhler (1998) compared various traditional nebulizers and found a large variation in the predicted lung dosage between the devices.…”

Section: Advances In Delivery Devicesmentioning

confidence: 99%

Improving the Likelihood of Success in Trials and the Efficiency of Delivery of Mucolytics and Antibiotics

Lange¹

2012

Cystic Fibrosis - Renewed Hopes Through Research

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“…In situ measurement is especially useful in sizing volatile aerosols, where particle (droplet) sizes change with time [102,103] . However, because the PDPA measures particle sizes at a precise location in the fl ow, determined by the intersection of the two laser beams, it is important either to perform measurements at several locations across the fl ow or to choose one location for which measurements are representative of the overall aerosol size distribution.…”

Section: Inertial Impactorsmentioning

confidence: 99%

“…Where should the aerosol size distribution be measured, and what does the distribution represent? One approach is to measure droplet sizes as close to the mouthpiece of the delivery system as is possible [103,105] . The meaof HFA pMDIs may be found in Vervaet and Byron [112] and in Smyth [113] .…”

Section: Evaporation and Condensationmentioning

confidence: 99%

“…Clark [105] has described the use of laser diffraction instruments for sizing nebulizer aerosols, while Smaldone and Lesouef [138] have described sizing of nebulizer aerosols using low fl ow rate cascade impactors. In addition, Finlay et al [103] combined size measurements for a range of jet nebulizers made using a phase Doppler particle analyzer with a mathematical deposition model to accurately estimate in vivo lung deposition data. In predicting respiratory tract deposition from measured droplet size distributions, it must be ensured that any effect of breathing pattern on aerosol production, as occurs for some vented nebulizers [103] , is accurately captured in the experimental setup.…”

Section: Condensation Aerosolsmentioning

confidence: 99%

See 1 more Smart Citation

Aerosol Drug Delivery to the Lungs

Finlay

2011

Pharmaceutical Sciences Encyclopedia

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This chapter will begin with a very brief introduction to aerosol mechanics as related to the transport and deposition of inhaled drug particles throughout the respiratory tract. This familiarization then will serve as requisite background for the discussion of aerosol particle sizing instruments in use for research and development, regulatory, and quality assurance purposes, as well as for descriptions of the different types of aerosol delivery systems currently available and in development.

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Variations in Predicted Regional Lung Deposition of Salbutamol Sulphate Between 19 Nebulizer Types

Cited by 33 publications

References 26 publications

Bridging the Gap Between Science and Clinical Efficacy: Physiology, Imaging, and Modeling of Aerosols in the Lung

Bridging the Gap Between Science and Clinical Efficacy: Physiology, Imaging, and Modeling of Aerosols in the Lung

Improving the Likelihood of Success in Trials and the Efficiency of Delivery of Mucolytics and Antibiotics

Aerosol Drug Delivery to the Lungs

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