Variations in the Catechol O-methyltransferase Polymorphism and Prefrontally Guided Behaviors in Adolescents

Wahlstrom, Dustin; White, Tonya; Hooper, Catalina J.; Vrshek‐Schallhorn, Suzanne; Oetting, William S.; Brott, Marcia J.; Luciana, Mónica

doi:10.1016/j.biopsych.2006.05.045

Cited by 59 publications

(68 citation statements)

References 48 publications

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“…To test this hypothesis, future studies might use tasks that enable more precise segregation of cognitive processes. However, positive associations with COMT genotype have now been reported across a very broad range of cognitive phenotypes 13,30,31,[38][39][40] as well as with structural 41,42 and functional 34,[43][44][45] brain measures. These wide-ranging reports suggest that COMT's effects on cognition may be relatively widespread.…”

Section: Discussionmentioning

confidence: 99%

Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls

et al. 2007

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The catechol-O-methyltransferase (COMT) Val 158 Met polymorphism is hypothesized to affect executive function in patient and control populations. Studies inconsistently report better performance on the Wisconsin Card Sort Test (WCST) in individuals with one or more Met alleles. We conducted a meta-analysis of studies published until August 2006 that reported WCST perseverative errors from healthy volunteers or patients with schizophrenia-spectrum disorders. Twelve studies met inclusion criteria (total n = 1910) providing 10 samples each of patients and controls. In healthy controls, individuals with the Met/Met genotype performed better than those with the Val/Val genotype (d = 0.29; 95% confidence interval (CI) 0.02-0.55; P = 0.03), but this was not supported in the patient sample (d = À0.07; 95% CI À0.40 to 0.26; P = 0.68). Post hoc analyses suggested that Val and Met alleles are codominant in their effects on cognition. Effect size was greater in studies published at an earlier date and may also be larger in non-Caucasian samples. Gender did not affect the results. There was no evidence of publication bias. We conclude that there is small but significant relationship between Val 158 Met genotype and executive function in healthy individuals but not in schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls

et al. 2007

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“…In sum, while data regarding the influences of the COMT gene upon cognitive functions and the pre-frontal dopamine activity are quite consistent across different life periods [15,53], the evidence for an influence of the COMT gene upon childhood behavioural disorders is less robust. This could be due to the inherent complexity of the mechanisms that underlie the influence of the COMT gene upon childhood psychopathology, such as gene-environment interplay effects, and/or the fact that the COMT gene could be operant only for some distinct subtypes of externalizing disorders.…”

Section: Introductionmentioning

confidence: 90%

“…The COMT genotype was also demonstrated to impact on cognitive functions that depend on pre-frontal dopaminergic activity in children and adolescents [15,53], and the Met allele predicted promptness as indexed by the ERP N170 waveform latency in normally developing children during a task of implicit face expressions' processing [4].…”

Section: Introductionmentioning

confidence: 98%

COMT Val158Met polymorphism and socioeconomic status interact to predict attention deficit/hyperactivity problems in children aged 10–14

Nobile

Rusconi

Bellina

et al. 2009

Eur Child Adolesc Psychiatry

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The functional Val158Met COMT polymorphism appears to affect a host of behaviours mediated by the pre-frontal cortex, and has been found associated to the risk for disruptive behaviours including ADHD. Parental socioeconomic status (SES) has also been reported as a predictor for the same childhood disorders. In a general population sample of 575 Italian pre-adolescents aged 10-14, we examined the association of the functional Val158Met COMT polymorphism and SES-both as linear and interactive effects-with oppositional defiant problems, conduct problems, and attention deficit/hyperactivity problems, as defined by the newly established Child Behaviour Check-List/6-18 DSM oriented scales. Multivariate-and subsequent univariate-analysis of covariance showed a significant association of COMT 9 SES interaction with CBCL 6/18 DOS attention deficit/hyperactivity problems (p = 0.004), and revealed higher scores among those children with Val/Val COMT genotype who belonged to low-SES families. We also found a significant association of SES with attention deficit/hyperactivity problems and conduct problems DOS (p = 0.04 and 0.01, respectively). Our data are consistent with a bulk of recent literature suggesting a role of environmental factors in moderating the contribution of specific genetic polymorphisms to human variability in ADHD. While future investigations will refine and better clarify which specific environmental and genetic mechanisms are at work in influencing the individual risk to ADHD in pre-adolescence, these data may contribute to identify/prevent the risk for ADHD problems in childhood.

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“…Behavioral findings are mixed (21)(22)(23). This lack of consistency may arise from age differences in the effect of COMT genotype on cognition.…”

Section: Introductionmentioning

confidence: 99%

Influence of the COMT Genotype on Working Memory and Brain Activity Changes During Development

Dumontheil¹,

Roggeman²,

Ziermans³

et al. 2011

Biological Psychiatry

146

148

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Variations in the Catechol O-methyltransferase Polymorphism and Prefrontally Guided Behaviors in Adolescents

Cited by 59 publications

References 48 publications

Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls

Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls

COMT Val158Met polymorphism and socioeconomic status interact to predict attention deficit/hyperactivity problems in children aged 10–14

Influence of the COMT Genotype on Working Memory and Brain Activity Changes During Development

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