Variations in the fat mass and obesity–associated (FTO) gene are related to glucose levels and higher lipid accumulation product in postmenopausal women from southern Brazil

Ramos, Ramon Bossardi; Casanova, Gislaine Krolow; Maturana, Maria Augusta; Spritzer, Poli Mara

doi:10.1016/j.fertnstert.2011.07.1148

Cited by 11 publications

(16 citation statements)

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“…In addition, while few studies in patients with PCOS failed to find an association with glucose levels (Kowalska et al, 2012;Kim et al, 2014;Song do et al, 2014), one study assessing the rs9939609 FTO variant and 10 metabolic traits using data from 17,037 white European individuals revealed evidence for an association between FTO genotype and fasting insulin, glucose, triglycerides, and HDL cholesterol . Recently, our group also confirmed the association between FTO genotypes and higher glucose levels in menopausal women (Ramos et al, 2011).…”

Section: Discussionsupporting

confidence: 75%

“…The chi-square test was used to compare categorical variables, and to assess deviation of the genotype frequencies from Hardy-Weinberg equilibrium. Previous studies have shown that the rs8050136 "A" allele is in strong linkage disequilibrium with the rs9939609 "A" allele (Frayling et al, 2007;Hotta et al, 2008;Ramos et al, 2011). For each studied polymorphism, patients were divided into two groups: one combined heterozygous and risk homozygous subjects into a single group and the second comprised non-risk homozygous subjects.…”

Section: Discussionmentioning

confidence: 99%

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FTO gene variants are not associated with polycystic ovary syndrome in women from Southern Brazil

Ramos

Spritzer

2015

Gene

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

FTO gene variants are not associated with polycystic ovary syndrome in women from Southern Brazil

Ramos

Spritzer

2015

Gene

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“…The FTO rs9939609 (T/A) polymorphism was shown to be associated with both obesity and T2DM in many populations, including the Brazilian. 13,14 The FTO-diabetes association is abolished by adjustment for body mass index (BMI), suggesting that this association is mediated through its effect on adiposity. 4,8 The extent to which this inherited predisposition to obesity may influence the response to dietary interventions is scarcely investigated.…”

Section: Introductionmentioning

confidence: 99%

FTO T/A and Peroxisome Proliferator-Activated Receptor-γ Pro12Ala Polymorphisms but Not ApoA1 −75 Are Associated with Better Response to Lifestyle Intervention in Brazilians at High Cardiometabolic Risk

Curti

Rogero

Baltar

et al. 2013

Metabolic Syndrome and Related Disorders

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In Brazilian individuals, the FTO T/A polymorphism induces a favorable impact on inflammatory status and glucose metabolism. The reference genotype of PPARγ Pro12Ala seems to favor a better lipid profile, while the variant allele decreases blood pressure. Our data did not support benefits of the variant allele of ApoA1 -75G/A polymorphism. Further studies are needed to direct lifestyle intervention to subsets of individuals at cardiometabolic risk.

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“…A amostra do estudo de Jacobsson et al (2011) foi composta por uma idade média de 70.20 anos, a qual é similar a deste trabalho (66.50 anos) e Ramos et al (2011) estudaram mulheres em período pós menopausa (idade media de 52 anos), como a amostra desse estudo. As demais pesquisas que, diferentemente, encontraram associação entre o rs9939609 e fenótipos ligados à obesidade (Frayling et al, 2007;Liu et al, 2010) possuem médias de idade diferentes e amplitude de idades elevadas.…”

Section: Discussionunclassified

“…Não obstante, a literatura disponível é controversa em relação ao gene FTO, pois embora alguns estudos tenham observado associação (Frayling et al, 2007;Liu et al, 2010), outros não confirmaram esses resultados (Jacobsson et al, 2009(Jacobsson et al, , 2011Ramos, Casanova, Maturana, & Spritzer, 2011). Nesse sentido, poucos estudos foram conduzidos em indivíduos idosos e limitaram-se a utilização do IMC como método de avaliação da composição corporal.…”

Section: Introductionunclassified

Estudo de associação entre polimorfismos no gene FTO e composição corporal em idosas brasileiras

Lunardi¹,

Pereira

Leite

et al. 2016

motricidade

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RESUMOEstudos de associação genética (GWAS) sugerem uma importante contribuição do gene candidato FTO na composição corporal em diferentes populações e variada faixa etária. Este estudo teve como objetivo examinar a associação entre os polimorfismos no gene FTO (rs9939609 e rs1861868) e fenótipos de adiposidade em uma amostra de idosas brasileiras não caucasianas. A amostra foi composta por 241 mulheres (66.65± 5.5 anos). Os dados referentes à composição corporal foram mensurados através da absorciometria por raios-x de dupla energia (DXA) e a genotipagem dos SNPs foi realizada utilizando o sistema SnaPShot Multiplex System (Applied Biosystems). Não foram encontradas diferenças estatisticamente significativas para as variáveis de composição corporal entre os polimorfismos estudados, mesmo após o ajuste para ancestralidade Africana. Especificamente, índice de massa corporal (p= 0.94 e p= 0.66), percentual de gordura (p= 0.42 e p= 0.93) e massa livre de gordura total (p= 0.75 e p= 0.30), sendo os valores de p referentes aos rs9939609 e rs1861868, respectivamente. Nesta amostra de idosas brasileiras os polimorfismos do gene FTO (rs9939609 e rs1861868) não apresentaram associação com fenótipos de obesidade.Palavras-chave: genética, obesidade, idosos, mulher, densitometria, IMC, gene FTO ABSTRACT GenomeWide Association Studies (GWAS) suggest an important contribution of gene FTO in body composition and muscle strength in different populations and wide age. This study intended to examine the association of polymorphisms in the FTO gene (rs9939609 and rs1861868) with obesity phenotypes in a sample of Brazilian elderly women not Caucasian. The sample included 241 older women. Data concerning body composition were measured by dual energy X-ray absorptiometry (DXA) and genotyping of SNPs was carried out using the system snapshot Multiplex System (Applied Biosystems). There was no statistically significant difference for body composition variables, even after adjustment for African ancestry. Specifically, body mass index (p= 0.94 and p= 0.66), fat percentage (p= 0.42 and p= 0.93) and total fat free mass (p= 0.75 and p= 0.30) did not present significant differences between genotypes (p values related to rs9939609 and rs1861868, respectively). In this sample of Brazilian elderly, the studied FTO gene polymorphisms (rs9939609 and rs1861868) are not associated with obesity-related phenotypes.

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Variations in the fat mass and obesity–associated (FTO) gene are related to glucose levels and higher lipid accumulation product in postmenopausal women from southern Brazil

Cited by 11 publications

References 52 publications

FTO gene variants are not associated with polycystic ovary syndrome in women from Southern Brazil

FTO gene variants are not associated with polycystic ovary syndrome in women from Southern Brazil

FTO T/A and Peroxisome Proliferator-Activated Receptor-γ Pro12Ala Polymorphisms but Not ApoA1 −75 Are Associated with Better Response to Lifestyle Intervention in Brazilians at High Cardiometabolic Risk

Estudo de associação entre polimorfismos no gene FTO e composição corporal em idosas brasileiras

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