Variations in the Relative Abundance of Gut Bacteria Correlate with Lipid Profiles in Healthy Adults

Abstract

The gut microbiome is a versatile system regulating numerous aspects of host metabolism. Among other traits, variations in the composition of gut microbial communities are related to blood lipid patterns and hyperlipidaemia, yet inconsistent association patterns exist. This study aims to assess the relationships between the composition of the gut microbiome and variations in lipid profiles among healthy adults. This study used data and samples from 23 adult participants of a previously conducted dietary intervention study. Circulating lipid measurements and whole-metagenome sequences of the gut microbiome were derived from 180 blood and faecal samples collected from eight visits distributed across an 11-week study. Lipid-related variables explained approximately 4.5% of the variation in gut microbiome compositions, with higher effects observed for total cholesterol and high-density lipoproteins. Species from the genera Odoribacter, Anaerostipes, and Parabacteroides correlated with increased serum lipid levels, whereas probiotic species like Akkermansia muciniphila were more abundant among participants with healthier blood lipid profiles. An inverse correlation with serum cholesterol was also observed for Massilistercora timonensis, a player in regulating lipid turnover. The observed correlation patterns add to the growing evidence supporting the role of the gut microbiome as an essential regulator of host lipid metabolism.

Structural Variances in Curcumin Degradants: Impact on Obesity in Mice

“…39 On the other hand, Massilistercora timonensis has an inverse correlation to the serum cholesterol, showing its potential in lipid regulation. 40 In summary, our study is the first to investigate and discuss the physiological function of curcuminoid degradants, FER and DFER, in HFD-induced obesity in a mouse model (Table 2).…”

“…It was reported that the risk of disease caused by Streptococcus infection was found to increase in adults with obesity and diabetes . On the other hand, Massilistercora timonensis has an inverse correlation to the serum cholesterol, showing its potential in lipid regulation …”

“… 39 On the other hand, Massilistercora timonensis has an inverse correlation to the serum cholesterol, showing its potential in lipid regulation. 40 …”