Varicocele as a risk factor for androgen deficiency and effect of repair

Tanrikut, Cigdem; Goldstein, Marc; Rosoff, James S.; Lee, Richard K.; Nelson, Christian J.; Mulhall, John P.

doi:10.1111/j.1464-410x.2010.10030.x

Cited by 156 publications

(117 citation statements)

References 37 publications

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“…Some studies have reported lower testosterone levels in varicocele patients. 28 Ferrucci and colleagues reported that men in the lowest quartile of total and bioavailable testosterone were more likely to have anemia. 29 Although we did not study serum testosterone lev� els in this study, the lower hemoglobin in the varicocele group could be associated with low testosterone levels.…”

Section: Coban Et Almentioning

confidence: 99%

Does varicocele correction lead to normalization of preoperatively elevated mean platelet volume levels?

Çoban

Ibrahim

Bıyık

et al. 2015

CUAJ

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Introduction: There are several studies on the relationship between increased mean platelet volume (MPV) and varicocele. �e inves� �e inves� tigated the relationship between preoperative and 6�month post� operative MPV values in patients whose varicocele was corrected with surgery. Methods: A total of 282 patients underwent surgery at our urology clinic between December 2011 and December 2013 for primary varicocele. �e retrospectively examined the records of 61 patients who came to the 6�month postoperative follow�up. The preop� erative varicocele diagnosis was made with physical examination findings and supported with colour Doppler ultrasonography. Results: The varicocele was grade I in 12 patients, grade II in 34 patients and grade III in 11 patients. �hen the preoperative and 6�month postoperative haemoglobin (Hb), MPV, mean corpuscular volume, platelet, and platelet distribution width (PD�) values were compared, there was a significant decrease in MPV (p = 0.019), and a significant increase in Hb (p < 0.001). A noticeable increase was also present in PD�, but it was not statistically significant (p = 0.058). Conclusion: �e found that MPV increased in patients with varic� ocele and tended to decrease again after the varicocele was sur� gically corrected. However, we feel larger prospective series are needed.

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Section: Coban Et Almentioning

confidence: 99%

Does varicocele correction lead to normalization of preoperatively elevated mean platelet volume levels?

Çoban

Ibrahim

Bıyık

et al. 2015

CUAJ

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“…Despite evidences suggesting that varicocele may have an impact on testicular function, in our studied population, it was not observed. Maybe the reduced number of patients with grade 3 varicocele included in the study compared to previous reports (14) can explain it. To our knowledge, no previous study has reported the relationship of ageing, obesity and varicocele.…”

Section: Discussionmentioning

confidence: 78%

“…Based on these evidences, we can assume that men with varicocele may be at risk for premature androgen deficiency and that varicocele repair may reduce this risk. A recent study showed that microsurgical varicocele ligation resulted in a significant increase in serum testosterone levels in more than two-thirds of men (14). In addition, some studies have shown that BMI has a protective effect for the development of varicocele (33,34).…”

Section: Discussionmentioning

confidence: 99%

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1235 Impact of Body Mass Index, Age and Varicocele on Reproductive Hormone Profile in Elderly Men

Yamaçake¹,

Cocuzza²,

Torriceli³

et al. 2013

Journal of Urology

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ARTICLE InfO ______________________________________________________________ ______________________Objectives: To study the impact of obesity, age and varicocele on sexual hormones fof adult and elderly men. Materials and Methods: 875 men who were screened for prostate cancer were enrolled in this study. Data recorded comprised age, body mass index (BMI), serum levels of total testosterone (TT), free testosterone (FT), sex hormone-binding globulin (SHBG), luteinizing hormone (LH) and follicular stimulating hormone (FSH). Patients were divided in groups according to their BMI in underweight, normal weight, overweight and obese grades 1, 2 or 3. First, it was studied the association between age, BMI, and hormone profile. Then, clinical varicocele was evaluated in 298 patients to assess its correlation to the others parameters. Results: Obese patients had lower levels of TT, FT and SHBG (p<0.001) compared to underweight or normal weight patients. There were no differences in age (p=0.113), FSH serum levels (p=0.863) and LH serum levels (p=0.218) between obese and non-obese patients. Obese grade 3 had lower levels of TT and FT compared to obese grade 1 and 2 (p<0.05). There was no difference in the SHBG levels (p=0.120) among obese patients. There was no association between varicocele and BMI; and varicocele did not impact on testosterone or SHBG levels. Conclusions: Men with higher BMI have a lower serum level of TT, FT and SHBG. The presence of clinical varicocele as well as its grade has no impact on hormone profile in elderly men.

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“…Although several reports documented a significant increase in serum testosterone post-operatively (Tanrikut et al, 2011;Hsiao et al, 2013), others failed to echo such an improvement (Pierik et al, 2001;Rodriguez Pena et al, 2009). Similarly, no statistically significant influence on serum testosterone level was detected in this cohort.…”

Section: Discussionmentioning

confidence: 99%

Does the number of veins ligated during varicococele surgery influence post-operative semen and hormone results?

et al. 2016

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SUMMARYVaricocele is a well-established cause of male subfertility, which is directly proportional to its clinical grade. Although newer ultrasonic grading systems have taken into account the existence of pampiniform venous plexi, little is known about the clinical significance of the number of veins ligated during surgery. Very few undersized studies reported an influence which triggered the need to evaluate such association. This is a retrospective study of 378 patients who underwent left microsurgical subinguinal varicocoelectomy. Semen analyses and blood hormone studies performed pre-operatively were compared to those executed 6 months after surgery. Patients were divided into abnormal semen and normal semen groups based on their initial semen results. They were also subdivided according to the number of veins ligated intraoperatively into three groups: <5, 5-10, and >10 veins. Sperm count, total motility, and progressive motility were significantly increased in 62, 60.3, and 53.3% of patients post-operatively (p = 0.001), respectively. No significant differences in hormone levels were detected overall. Of the 378 patients, 332 had an abnormal semen analysis, while the remaining 46 patients had a normal result. Sperm count, total motility, and progressive motility significantly increased after varicocoelectomy in patients with an abnormal initial semen analysis (p = 0.001). In 48.7% of patients, 5-10 veins were ligated during surgery, whereas 28.3% had >10 and 23% had <5 ligated veins. No statistically significant differences were noted in the initial or the follow-up results among the number of vein subgroups. Varicocele ligation improves patients' fertility potential. This improvement, however, is not influenced by the number of veins ligated intraoperatively. Clinical grading maintains its superiority in the evaluation of varicocele patients.

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Varicocele as a risk factor for androgen deficiency and effect of repair

Cited by 156 publications

References 37 publications

Does varicocele correction lead to normalization of preoperatively elevated mean platelet volume levels?

Does varicocele correction lead to normalization of preoperatively elevated mean platelet volume levels?

1235 Impact of Body Mass Index, Age and Varicocele on Reproductive Hormone Profile in Elderly Men

Does the number of veins ligated during varicococele surgery influence post-operative semen and hormone results?

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