Variegatic acid from the edible mushroom Tylopilus ballouii inhibits TNF-α production and PKCβ1 activity in leukemia cells

Sugaya, Kouichi; Ino, Mutsumi; Matsuo, Naoki; Onose, Jun‐ichi; Abe, Naoki

doi:10.1016/j.bmcl.2019.126886

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…Numerous mushroom bioactive metabolites such as variegatic acid from Tylopilus ballouii (Sugaya et al., 2020), proteoglycans and ergosterol from A. blazei (Sun et al., 2020), Pleurotus ostreatus extract (Ebrahimi et al., 2018), ethanol extracts from A. bisporus (Jagadish et al., 2009) and water‐soluble polysaccharide from Inonotus taiwanensis (Chao et al., 2018) inhibited the proliferation of leukemia cells and other human leukemia cell lines via the induction of apoptosis. A variegatic acid, isolated from Tylopilus ballouii dry fruiting bodies, inhibited β‐hexosaminidase release and tumor necrosis factor (TNF)‐α secretion from rat basophilic leukemia (RBL‐2H3) cells, as well as PKCβ1 activity (Sugaya et al., 2020). The Pleurotus ostreatus extract decreased the proliferation of leukemia cell lines (KG‐1 and Jurkat cells) but had no antiproliferative effects on bone marrow mesenchymal stem cells.…”

Section: Nutraceutical Potential Of Mushroom Bioactive Metabolitesmentioning

confidence: 99%

Nutraceutical potential of mushroom bioactive metabolites and their food functionality

Ishara

Buzera

Mushagalusa

et al. 2021

Journal of Food Biochemistry

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Numerous mushroom bioactive metabolites, including polysaccharides, eritadenine, lignin, chitosan, mevinolin, and astrakurkurone have been studied in life‐threatening conditions and diseases such as diabetes, cardiovascular, hypertension, cancer, DNA damage, hypercholesterolemia, and obesity attempting to identify natural therapies. These bioactive metabolites have shown potential as antiviral and immune system strengthener natural agents through diverse cellular and physiological pathways modulation with no toxicity evidence, widely available, and inexpensive. In light of the emerging literature, this paper compiles the most recent information describing the molecular mechanisms that underlie the nutraceutical potentials of these mushroom metabolites suggesting their effectiveness if combined with existing drug therapies while discussing the food functionality of mushrooms. The findings raise hope that these mushroom bioactive metabolites may be utilized as natural therapies considering their therapeutic potential while anticipating further research designing clinical trials and developing new drug therapies while encouraging their consumption as a natural adjuvant in preventing and controlling life‐threatening conditions and diseases. Practical applications Diabetes, cardiovascular, hypertension, cancer, DNA damage, hypercholesterolemia, and obesity are among the world's largest life‐threatening conditions and diseases. Several mushroom bioactive compounds, including polysaccharides, eritadenine, lignin, chitosan, mevinolin, and astrakurkurone have been found potential in tackling these diseases through diverse cellular and physiological pathways modulation with no toxicity evidence, suggesting their use as nutraceutical foods in preventing and controlling these life‐threatening conditions and diseases.

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Section: Nutraceutical Potential Of Mushroom Bioactive Metabolitesmentioning

confidence: 99%

Nutraceutical potential of mushroom bioactive metabolites and their food functionality

Ishara

Buzera

Mushagalusa

et al. 2021

Journal of Food Biochemistry

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A Review of the Chemistry and Biological Activities of Natural Colorants, Dyes, and Pigments: Challenges, and Opportunities for Food, Cosmetics, and Pharmaceutical Application

Pasdaran

Zare

Hamedi

et al. 2023

Chemistry & Biodiversity

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Natural pigments are important sources for the screening of bioactive lead compounds. This article reviewed the chemistry and therapeutic potentials of over 570 colored molecules from plants, fungi, bacteria, insects, algae, and marine sources. Moreover, related biological activities, advanced extraction, and identification approaches were reviewed. A variety of biological activities, including cytotoxicity against cancer cells, antioxidant, anti‐inflammatory, wound healing, anti‐microbial, antiviral, and anti‐protozoal activities, have been reported for different pigments. Considering their structural backbone, they were classified as naphthoquinones, carotenoids, flavonoids, xanthones, anthocyanins, benzotropolones, alkaloids, terpenoids, isoprenoids, and non‐isoprenoids. Alkaloid pigments were mostly isolated from bacteria and marine sources, while flavonoids were mostly found in plants and mushrooms. Colored quinones and xanthones were mostly extracted from plants and fungi, while colored polyketides and terpenoids are often found in marine sources and fungi. Carotenoids are mostly distributed among bacteria, followed by fungi and plants. The pigments isolated from insects have different structures, but among them, carotenoids and quinone/xanthone are the most important. Considering good manufacturing practices, the current permitted natural colorants are: Carotenoids (canthaxanthin, β‐carotene, β‐apo‐8′‐carotenal, annatto, astaxanthin) and their sources, lycopene, anthocyanins, betanin, chlorophyllins, spirulina extract, carmine and cochineal extract, henna, riboflavin, pyrogallol, logwood extract, guaiazulene, turmeric, and soy leghemoglobin.

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The blue palette of life: A comprehensive review of natural bluish colorants with potential commercial applications

Ishimoto,

Paulino,

Neri-Numa

et al. 2024

Food Research International

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Variegatic acid from the edible mushroom Tylopilus ballouii inhibits TNF-α production and PKCβ1 activity in leukemia cells

Cited by 3 publications

References 10 publications

Nutraceutical potential of mushroom bioactive metabolites and their food functionality

Nutraceutical potential of mushroom bioactive metabolites and their food functionality

A Review of the Chemistry and Biological Activities of Natural Colorants, Dyes, and Pigments: Challenges, and Opportunities for Food, Cosmetics, and Pharmaceutical Application

The blue palette of life: A comprehensive review of natural bluish colorants with potential commercial applications

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