Various techniques for the routine evaluation of the degradation of glucose in parenteral solutions — a critical study

Postaire, E.; Pradier, F.; Postaire, M.; Pradeau, D.; Matchoutsky, L.; Prognon, Patrice; Hamon, Michel

doi:10.1016/0731-7085(87)80036-5

Cited by 5 publications

(10 citation statements)

References 12 publications

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“…In their study, Postaire et al . demonstrated that the higher the temperature, the higher the GPD formation rate, and independently, the longer the sterilisation time, again the higher the GPD formation rate 32 , which is confirmed in Cook’s study 5 . Kjellstrand et al .…”

Section: Discussionsupporting

confidence: 57%

“…Indeed in this study, both 5-HMF and 2-FA were identified and quantified in all marketed solutions tested. In previously published studies, 5-HMF concentrations ranged from 0.25 to 18.4 mg/L in infusion fluids for glucose concentrations from 2.5 to 30% 1 , or from 7.94 to 36.46 mg/L for glucose concentrations from 10 to 50% 32 . No data is available for 2-FA in infusion fluids, only in peritoneal dialysis fluids.…”

Section: Discussionmentioning

confidence: 94%

“…F 0 is a combination of time and temperature giving equal energy/bacterial lethality 16 . However, the value alone of F 0 is insufficient; it is important to know the thermodynamic conditions of sterilisation 32 . In their study, Postaire et al .…”

Section: Discussionmentioning

confidence: 99%

“…Little data is at present available on the quantification of GDPs in glucose solutions for intravenous administration 1 , 14 , 15 , 32 . Many questions remain unanswered, particularly regarding the risks involved in the chronic administration of sterile glucose solutions or those associated with chemical interactions with new protein-structured drugs (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…antibodies, biosimilars…), which raise the issue of drug glycation before administration 33 , 34 . Many factors have previously been identified as factors contributing to the formation of GDPs in infusion bags: sterilisation process 5 , storage conditions 7 or amount of glucose 32 . However, some others have never been tested (e.g.…”

Section: Introductionmentioning

confidence: 99%

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Factors Generating Glucose Degradation Products In Sterile Glucose Solutions For Infusion: Statistical Relevance Determination Of Their Impacts

Haybrard¹,

Simon²,

Danel³

et al. 2017

Sci Rep

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Sterilising glucose solutions by heat promotes the generation of a large number of glucose degradation products (GDPs). It has been shown that high levels of GDPs may result in Advanced Glycation End products that have an impact on cellular homeostasis and health in general. If data is available for peritoneal dialysis solutions, little has been published for glucose infusion fluids. It is essential to identify the parameters causing the formation of GDPs and so limit the risk of exposing patients to them. After quantifying both 5-hydroxymethyl-2-furfural, considered as an important indicator of degradation, and 2-furaldehyde, an ultimate GDP of one degradation pathway, in marketed solutions, the aim of this work is to build a model integrating all the parameters involved in the formation rates of these two GDPs: supplier, glucose amount, container material, oxygen permeability coefficient and time-lapse since manufacture. Our results show a good logarithmic relationship between GDP formation rates and time-lapse since manufacture for both GDPs. The amount of GDPs in the glucose solutions for infusion depends on the initial glucose amount, the polymer of the container, the time elapsed since manufacturing and the supplier.

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 94%