Various theranostics and immunization strategies based on nanotechnology against Covid-19 pandemic: An interdisciplinary view

Chatterjee, Sabyasachi; Mishra, Snehasis; Chowdhury, Kaustav Dutta; Ghosh, Chandan Kumar; Saha, Krishna Das

doi:10.1016/j.lfs.2021.119580

Cited by 6 publications

(4 citation statements)

References 246 publications

(226 reference statements)

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“…INO-4800, a DNA vaccine, was developed and customized by Inovio Pharmaceuticals and International Vaccine Institute, using DNA coated-PLGA nanoparticles. This vaccine is intradermally administrated through nano-based electroporation device named CELLECTRA®2000 and induces neutralizing antibodies and T cell activity (88)(89).…”

Section: Use Of Nanotechnology For Covid-19 Vaccinesmentioning

confidence: 99%

Nano-based Strategies Against COVID-19: Prevention and Therapeutics

Varshney¹,

Chand²,

Prasad³

2022

ECS Trans.

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COVID-19 disease is an ongoing global pandemic caused by contagious SARS-CoV-2 and represents an unprecedented public health concern. No treatment for COVID-19 is validated yet, however various vaccines are approved for emergency use. Due to rapid virus spread and disease outbreak, an alternative approach to combat the virus is essentially required. In this regard, nanotechnology certainly offers new opportunities to develop safe, sustainable, and novel approaches for effective prevention and treatment of COVID-19. Various such approaches under research and development include inhibition of SARS-CoV-2 entry into host cell by nanoparticles or membrane derived nanodecoys, prevention of viral contamination via disinfectants, nano-based drug delivery system for targeted, sustained and controlled drug release, and nano-based vaccines to boost cellular and humoral responses.

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Section: Use Of Nanotechnology For Covid-19 Vaccinesmentioning

confidence: 99%

Nano-based Strategies Against COVID-19: Prevention and Therapeutics

Varshney¹,

Chand²,

Prasad³

2022

ECS Trans.

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“…Thus, there is no doubt about the potential of nanotechnology [108]. Any link in the whole process of SARS-CoV-2 infecting target cells and causing disease can be targeted by nanodrugs [109].…”

Section: Application Of Nanoplatforms In Covid-19 Treatmentmentioning

confidence: 99%

Nanomaterials as Promising Theranostic Tools in Nanomedicine and Their Applications in Clinical Disease Diagnosis and Treatment

et al. 2021

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In recent decades, with the rapid development of nanotechnology, nanomaterials have been widely used in the medical field, showing great potential due to their unique physical and chemical properties including minimal size and functionalized surface characteristics. Nanomaterials such as metal nanoparticles and polymeric nanoparticles have been extensively studied in the diagnosis and treatment of diseases that seriously threaten human life and health, and are regarded to significantly improve the disadvantages of traditional diagnosis and treatment platforms, such as poor effectiveness, low sensitivity, weak security and low economy. In this review, we report and discuss the development and application of nanomaterials in the diagnosis and treatment of diseases based mainly on published research in the last five years. We first briefly introduce the improvement of several nanomaterials in imaging diagnosis and genomic sequencing. We then focus on the application of nanomaterials in the treatment of diseases, and select three diseases that people are most concerned about and that do the most harm: tumor, COVID-19 and cardiovascular diseases. First, we introduce the characteristics of nanoparticles according to the excellent effect of nanoparticles as delivery carriers of anti-tumor drugs. We then review the application of various nanoparticles in tumor therapy according to the classification of nanoparticles, and emphasize the importance of functionalization of nanomaterials. Second, COVID-19 has been the hottest issue in the health field in the past two years, and nanomaterials have also appeared in the relevant treatment. We enumerate the application of nanomaterials in various stages of viral pathogenesis according to the molecular mechanism of the complete pathway of viral infection, pathogenesis and transmission, and predict the application prospect of nanomaterials in the treatment of COVID-19. Third, aiming at the most important causes of human death, we focus on atherosclerosis, aneurysms and myocardial infarction, three of the most common and most harmful cardiovascular diseases, and prove that nanomaterials could be involved in a variety of therapeutic approaches and significantly improve the therapeutic effect in cardiovascular diseases. Therefore, we believe nanotechnology will become more widely involved in the diagnosis and treatment of diseases in the future, potentially helping to overcome bottlenecks under existing medical methods.

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“…It has been pointed out that among these SARS-CoV-2 variants, there may be variants that increase infectivity and transmissibility, alter antigenicity, and even reduce immunity and vaccine efficacy [7][8][9][10]. The development of therapeutic agents for COVID-19 is also being actively pursued, and in fact, drugs such as remdesivir, dexamethasone, and baricitinib have been approved and are being used in clinical practice [11,12]. However, current treatment for COVID-19 is mainly symptomatic, and although several experimental therapies are being actively studied in clinical trials, in some cases, there is insufficient high-quality evidence to recommend early treatment [13,14].…”

Section: Introductionmentioning

confidence: 99%

Application of Artificial Intelligence in COVID-19 Diagnosis and Therapeutics

Asada

Komatsu

Shimoyama

et al. 2021

JPM

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The coronavirus disease 2019 (COVID-19) pandemic began at the end of December 2019, giving rise to a high rate of infections and causing COVID-19-associated deaths worldwide. It was first reported in Wuhan, China, and since then, not only global leaders, organizations, and pharmaceutical/biotech companies, but also researchers, have directed their efforts toward overcoming this threat. The use of artificial intelligence (AI) has recently surged internationally and has been applied to diverse aspects of many problems. The benefits of using AI are now widely accepted, and many studies have shown great success in medical research on tasks, such as the classification, detection, and prediction of disease, or even patient outcome. In fact, AI technology has been actively employed in various ways in COVID-19 research, and several clinical applications of AI-equipped medical devices for the diagnosis of COVID-19 have already been reported. Hence, in this review, we summarize the latest studies that focus on medical imaging analysis, drug discovery, and therapeutics such as vaccine development and public health decision-making using AI. This survey clarifies the advantages of using AI in the fight against COVID-19 and provides future directions for tackling the COVID-19 pandemic using AI techniques.

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Various theranostics and immunization strategies based on nanotechnology against Covid-19 pandemic: An interdisciplinary view

Cited by 6 publications

References 246 publications

Nano-based Strategies Against COVID-19: Prevention and Therapeutics

Nano-based Strategies Against COVID-19: Prevention and Therapeutics

Nanomaterials as Promising Theranostic Tools in Nanomedicine and Their Applications in Clinical Disease Diagnosis and Treatment

Application of Artificial Intelligence in COVID-19 Diagnosis and Therapeutics

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