Vascular Calcifying Progenitor Cells Possess Bidirectional Differentiation Potentials

Cho, Hyun-Ju; Cho, Hyun‐Jai; Lee, Hojae; Song, Myung-Kang; Seo, Ji-Yun; Bae, Yeon-Hee; Kim, Ju‐Young; Lee, Hae Young; Lee, Whal; Koo, Bon‐Kwon; Oh, Byung Hee; Park, Young-Bae; Kim, Hyo–Soo

doi:10.1371/journal.pbio.1001534

Cited by 35 publications

(42 citation statements)

References 57 publications

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“…However, there are also studies which have revealed some harmful effects of EPCs for the development of vascular disorders (Hu et al 2004;Tintut et al 2003;van Oostrom et al 2009;Campagnolo et al 2011;Flammer et al 2012;Chen et al 2013;Cho et al 2013). Vascular resident progenitor/stem cells could exhibit various harmful effects in cardiovascular pathology such as involvement in vessel mineralization (Tintut et al 2003;Flammer et al 2012;Cho et al 2013), neointimal formation (Hu et al 2004;van Oostrom et al 2009;Chen et al 2013), and intraplaque neovascularization (Campagnolo et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Vascular stem/progenitor cells: current status of the problem

2015

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Stem/progenitor cells residing in the vascular wall of post-natal vessels play a crucial role in angiogenesis and vascular regeneration after damage. There are four major populations of vascular-resident stem/progenitor cells with differentiated clonogenic and proliferative potential, namely mesenchymal stem cells, pericytes, endothelial progenitor cells, and smooth muscle progenitor cells. These progenitors reside in vascular stem cell niches, which are more likely to be in the adventitia, a vascular wall layer in which increased concentration of stem cell surface markers has been shown. Indeed, vascular resident progenitors are not uniformly distributed across the vessel wall and the circulatory system. The heterogeneity of such a distribution could contribute to the differentiated susceptibility of various vessel regions to chronic vascular diseases such as atherosclerosis. In cardiovascular pathology, adult vascular resident progenitors could play either a negative or a positive role.

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Section: Discussionmentioning

confidence: 99%

Vascular stem/progenitor cells: current status of the problem

2015

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“…This may account for the ancestry of some subtypes of calcifying vascular cells, such as Sca-1 + PDGFRα + and Sca-1 + PDGFRα − progenitors that have been recently described in mice. 116 …”

Section: Cd45mentioning

confidence: 99%

Vascular Wall Progenitor Cells in Health and Disease

Psaltis

Simari

2015

Circulation Research

173

155

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The vasculature plays an indispensible role in organ development and maintenance of tissue homeostasis, such that disturbances to it impact greatly on developmental and postnatal health. Although cell turnover in healthy blood vessels is low, it increases considerably under pathological conditions. The principle sources for this phenomenon have long been considered to be the recruitment of cells from the peripheral circulation and the re-entry of mature cells in the vessel wall back into cell cycle. However, recent discoveries have also uncovered the presence of a range of multipotent and lineage-restricted progenitor cells in the mural layers of postnatal blood vessels, possessing high proliferative capacity and potential to generate endothelial, smooth muscle, hematopoietic or mesenchymal cell progeny. In particular, the tunica adventitia has emerged as a progenitor-rich compartment with niche-like characteristics that support and regulate vascular wall progenitor cells. Preliminary data indicate the involvement of some of these vascular wall progenitor cells in vascular disease states, adding weight to the notion that the adventitia is integral to vascular wall pathogenesis, and raising potential implications for clinical therapies. This review discusses the current body of evidence for the existence of vascular wall progenitor cell subpopulations from development to adulthood and addresses the gains made and significant challenges that lie ahead in trying to accurately delineate their identities, origins, regulatory pathways, and relevance to normal vascular structure and function, as well as disease.

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“…• Calcifying progenitor cells with decalcifying potential [47] has been shown to have the capability to reverse atherosclerotic vascular calcification. The progenitor cells isolated from the aortas of mice had bidirectional, osteoblastic and osteoclastic lineage.…”

Section: Strategies To Reduce Vascular Calcification and Their Effectmentioning

confidence: 99%

The Role of Vascular Calcification in Heart Failure and Cognitive Decline

Cheng

Wang

2017

Pulse

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Vascular calcification is heterogeneous and triggered by multiple mechanisms. It has been implicated in the development of heart failure with preserved ejection fraction (HFpEF) and cognitive function impairment. Understanding the pathophysiology of vascular calcification may help us improve the management of HFpEF, atherosclerosis, accelerated arterial stiffness, hypertension, and cognitive dysfunction. Currently, there are no effective strategies for treating accelerated arterial stiffness. This may indicate that once arterial stiffness or vascular calcification has developed, it may be less likely to stop the ongoing pathophysiology. Therefore, earlier intervention targeting the probable pathways of vascular calcification may benefit the patients with vascular calcification and related pathological conditions. In this review, we briefly discuss the proposed pathophysiological roles of vascular calcification in the development of heart failure and cognitive decline, the animal models used to study the link between vascular calcification and cardiovascular diseases, and the possible corresponding management strategies.

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Vascular Calcifying Progenitor Cells Possess Bidirectional Differentiation Potentials

Abstract: Calcifying progenitor cells in blood vessels have the potential to differentiate into cells that either promote calcium accumulation or reverse accumulation, and treatment with PPAR? can shift the direction of this differentiation.

Cited by 35 publications

References 57 publications

Vascular stem/progenitor cells: current status of the problem

Vascular stem/progenitor cells: current status of the problem

Vascular Wall Progenitor Cells in Health and Disease

The Role of Vascular Calcification in Heart Failure and Cognitive Decline

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