Vascular changes in autoimmunological connective tissue diseases

Szymańska, Elżbieta; Wieczorek, Marta; Lagun, Zuzanna; Malewska, Aleksandra; Roszkiewicz, Marek; Walecka, Irena

doi:10.5603/aa.2016.0017

Cited by 4 publications

(6 citation statements)

References 15 publications

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“…The most common disease entities within this group include systemic lupus erythematosus, systemic sclerosis, dermatomyositis, mixed connective tissue disease, and Sjögren's syndrome. Vascular lesions may be present in even 20% of patients with systemic connective tissue disease [39,40]. They are a key part stimulating an immunological cascade leading to tissue inflammation.…”

Section: Vascular Changes In the Course Of Autoimmune Connective Tissmentioning

confidence: 99%

“…At an early disease stage, changes in architecture and vacuolation of vascular endothelial cells are observed. Damage of the endothelium causes a release of biologically active substances and development of chronic inflammation, intensifies proliferation of vascular smooth muscle cells and fibrosis, which may lead to vascular occlusion and ischaemia [39]. Microcirculation disorders are systemic, affect vessels of the skin, subcutis, muscles, and internal organs.…”

Section: Vascular Changes In the Course Of Autoimmune Connective Tissmentioning

confidence: 99%

“…Do najczęstszych jednostek chorobowych w tej grupie zalicza się: toczeń rumieniowaty układowy, twardzinę układową, zapalenie skórno-mięśniowe, mieszaną chorobę tkanki łącznej oraz zespół Sjögrena. Zmiany naczyniowe mogą być obecne nawet u 20% pacjentów z układową chorobą tkanki łącznej [39,40]. Stanowią one istotny element pobudzający white colour of the skin, then, deoxygenated blood makes the skin blue, and the third phase of active hyperaemia is characterized by erythematous colour.…”

Section: Zmiany Naczyniowe W Przebiegu Chorób Autoimmunologicznych Tkunclassified

“…We wczesnej fazie choroby obserwuje się zmiany architektoniki i wakuolizację komórek śródbłonka naczyniowego. Uszkodzenie śródbłonka powoduje uwolnienie substancji aktywnych biologicznie oraz rozwój przewlekłego stanu zapalnego, wzmaga proliferację komórek mięśniówki gładkiej naczyń i włóknienie, które mogą prowadzić do okluzji naczyń i niedokrwienia [39]. Zaburzenia mikrokrążenia mają charakter ogólnoustrojowy, dotyczą naczyń skóry, tkanki podskórnej, mięśni i narządów wewnętrznych.…”

Section: Zmiany Naczyniowe W Przebiegu Chorób Autoimmunologicznych Tkunclassified

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Sulodexide – unrealized potential in dermatology

Krasowska¹,

Polkowska-Pruszyńska²,

Michalak-Stoma³

2019

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Sulodexide is a highly purified mixture of glycosaminoglycans composed of fast mobility heparin (80%) and dermatan sulfate (20%). Glycosaminoglycans constitute a group of heteropolysaccharides consisting of repeating disaccharide units, which contain amino sugar combined with uronic acid or a hexose. Glycosaminoglycans build glycocalyx covering endothelium of blood vessels, and thus, play an important role in vascular homeostasis. Multi-directional activity of sulodexide including antithrombotic, fibrinolytic, anti-aggregation, anti-inflammatory, anti-proliferative, and anti-oxidative qualities, as well as a high safety profile have allowed using the drug in numerous entities. Advantageous results of sulodexide therapy are observed in diseases involving endothelial damage, prothrombotic or inflammatory states. Thanks to its pleiotropic effects, sulodexide can be also applied in treatment of skin diseases. streszczenie Sulodeksyd to wysoce oczyszczona mieszanina glikozaminoglikanów złożona w 80% z heparyny szybko przemieszczającej się w polu elektroforezy oraz w 20% z siarczanu dermatanu. Glikozaminoglikany są grupą heteropolisacharydów składających się z powtarzających się jednostek disacharydowych, zawierających aminocukier połączony z kwasem uronowym lub heksozą. Glikozaminoglikany stanowią budulec glikokaliksu pokrywającego śródbłonek naczyń krwionośnych i odgrywają istotną rolę w homeostazie naczyniowej. Wielokierunkowe działanie sulodeksydu obejmujące właściwości przeciwzakrzepowe, fibrynolityczne, antyagregacyjne, przeciwzapalne, antyproliferacyjne i antyoksydacyjne oraz wysoki profil bezpieczeństwa umożliwiły zastosowanie leku w wielu jednostkach chorobowych. Korzystne efekty terapii sulodeksydem obserwuje się w chorobach przebiegających z uszkodzeniem śródbłonka, ze stanami prozakrzepowymi i zapalnymi. Dzięki właściwościom plejotropowym sulodeksyd znalazł również zastosowanie w terapii chorób skóry.

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Section: Vascular Changes In the Course Of Autoimmune Connective Tissmentioning

confidence: 99%

Section: Vascular Changes In the Course Of Autoimmune Connective Tissmentioning

confidence: 99%

Section: Zmiany Naczyniowe W Przebiegu Chorób Autoimmunologicznych Tkunclassified

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Sulodexide – unrealized potential in dermatology

Krasowska¹,

Polkowska-Pruszyńska²,

Michalak-Stoma³

2019

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“…Erosions and ulcers, most commonly seen within the limbs, occur due to damaged blood vessels and chronic tissue ischemia. In many SSc patients, progressive structural changes developing within the minor arteries lead to permanent blood flow impairment and tissue necrosis [8].…”

Section: Introductionmentioning

confidence: 99%

Successful Intensification of Intravenous Rheological Treatment of Phalanges Ischemia in SSc Patient Using Alprostadil

Walecka¹,

Malewska²,

Lagun³

et al. 2017

J Cardiovasc Dis Diagn

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Systemic sclerosis (SSc) is a rare, auto immunological, connective tissue disease characterized by vasomotor disturbances, fibrosis and further atrophy of the skin and internal organs. There are many factors leading to immunological and vascular changes. One of the most prominent vascular symptoms is Raynaud's phenomenon, which may be caused by different factors such as cold or excessive stress. This case report presents a 37-year old Caucasian woman with SSc, with severely impaired microcirculation of the hands and necrosis of the distal phalanges due to several hours of exposure to the cold. The patient required intensification of intravenous rheological treatment with alprostadil and oral usage of sildenafil, which had a positive effect on the improvement of the impaired microcirculation. Like many others, this case demonstrates that IV. rheological treatment may be effective in restoring microcirculation in such cases among SSc patients.

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Association Between Exposure to Heavy Metals and Systemic Sclerosis: the Levels of Al, Cd, Hg, and Pb in Blood and Urine of Patients

Forte¹,

Bocca³

et al. 2018

Biol Trace Elem Res

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Systemic sclerosis (SSc) is a multisystem connective tissue disease; exogenous factors-including heavy metals-may have a role in the disease pathogenesis. In this context, a study on the quantification of Al, Cd, Hg, and Pb in blood and urine of 27 SSc patients and 30 controls was carried out. Main findings were that Al was significantly depleted in blood and increased in urine of SSc patients respect to controls; and Pb was found slightly increased in blood and significantly decreased in SSc group. In addition, higher Hg levels in urine were found in SSc subjects with the higher severity of the disease. Females showed the most marked differences in the levels of blood Al, blood Pb, and urine Cd between patients and controls. Smoking, hobby, ingestion of contaminated food, job exposure may contribute to the bodily levels of Al, Hg, Pb in SSc patients. The results indicated that low, chronic, and multiple exposures to heavy metals-also through habits, diet, and environment-may influence the risk for SSc.

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Vascular changes in autoimmunological connective tissue diseases

Abstract: Vascular

Cited by 4 publications

References 15 publications

Sulodexide – unrealized potential in dermatology

Sulodexide – unrealized potential in dermatology

Successful Intensification of Intravenous Rheological Treatment of Phalanges Ischemia in SSc Patient Using Alprostadil

Association Between Exposure to Heavy Metals and Systemic Sclerosis: the Levels of Al, Cd, Hg, and Pb in Blood and Urine of Patients

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