Vascular dysfunction in women with recurrent pregnancy loss: Possible association with antiphospholipid antibodies

Abstract

ObjectiveAntiphospholipid antibodies (aPL) are recognized to have a pivotal role in recurrent pregnancy loss (RPL) and cardiovascular disease. Therefore, we assessed the vascular function of women with RPL and examined the association with each type of aPL.MethodsIn this retrospective study, 569 women with RPL and 55 healthy women who had never experienced pregnancy loss were recruited. We performed blood tests for aPL and acceleration plethysmography (APG) to evaluate peripheral vascular function.ResultsThe differential pulse wave index (DPI), indicating vascular elasticity, was significantly lower in women with RPL (115.6 ± 4.1) compared to the control group (117.0 ± 2.3). DPI in RPL women with anti‐β2 glycoprotein I (aβ2GPI) IgG was significantly lower than those without. Remained blood volume (RBV), indicating post‐vasoconstriction blood content, was significantly higher in RPL women with aβ2GI IgG than in those without. Regression analysis showed aβ2GPI IgG and body mass index (BMI) linked negatively with DPI.ConclusionWomen with RPL have subclinical vascular dysfunction even at reproductive age. It is possible that aβ2GPI IgG is associated with vascular dysfunction in RPL women.