Vascular Endothelial Growth Factor +936C/T, –634G/C, –2578C/A, and –1154G/A Polymorphisms with Risk of Preeclampsia: A Meta-Analysis

Abstract

BackgroundEmerging evidence showed that VEGF gene polymorphisms are involved in the regulation of VEGF protein expression, thus increasing an individual's susceptibility to preeclampsia (PE); but individually published results are inconclusive. The aim of this meta-analysis was to investigate the associations between VEGF gene polymorphisms and PE risk.MethodsA systematic literature search of MEDLINE, Embase, Web of Science, and CNKI (Chinese National Knowledge Infrastructure) databases was conducted. Statistical analyses were performed using STATA 12.0 software and Review manager 5.1. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations.ResultsAccording to the inclusion criteria, 11 case-control studies were finally included in this meta-analysis. A total of 1,069 PE cases and 1,315 controls were included in this study. Our meta-analysis indicated that VEGF +936C/T (T vs. C, OR = 1.52, 95%CI = 1.08–2.12) or −634G/C polymorphism (C vs. G, OR = 1.24, 95% CI = 1.03–1.50) was associated with the risk of PE, whereas there was no association between −2578C/A (A vs. C, OR = 0.98, 95%CI = 0.82–1.16) or −1154G/A (A vs. G, OR = 1.30, 95%CI = 0.94–1.78) polymorphism and PE risk in our study.ConclusionOur meta-analysis suggested that VEGF −2578C/A or −1154G/A polymorphism had no association with PE risk in all examined patients, whereas there was an association between VEGF +936C/T or −634G/C polymorphism and risk of PE.

Genetic association between VEGF polymorphisms and BRONJ in the Korean population

“…We first identified an association between the rs2010963 and rs3025039 polymorphisms with BRONJ risk, suggesting the susceptibility of BRONJ may be conferred by C allele of rs2010963 and rs3025039. These results are partially consistent with previous studies reporting the rs2010963 polymorphism is significantly associated with VEGF expression (Watson et al , ; Cheng et al , ).…”

MTHFR and F5 genetic variations have association with preeclampsia in Pakistani patients: a case control study

“…VEGF is expressed in the placenta and has a significant role in its development and maintenance. VEGFA variants have been widely studied and its association with preeclampsia has been found in several studies, including Chinese, Brazilian, Hungarian and Korean patients [42][43][44][45]. However, our study negates the association of VEGFA: c.-2055A > C and c.*237C > T variants with preeclampsia in Pakistani patients.…”

Association between vascular endothelial growth factor promoter polymorphisms and the risk of recurrent implantation failure

“…Several single nucleotide polymorphisms (SNPs) have been previously detected in VEGF, including -2578C>A, -1154G>A, -634C>G and 936C>T, which are associated with altered VEGF expression (12)(13)(14)(15)(16). There have been several previous reports that VEGF polymorphisms are associated with the development and prognosis of a variety of obstetrical and gynecological diseases (17)(18)(19). Additionally, there have been reports that the VEGF -1154G>A and -634C>G polymorphisms are associated with the occurrence of RIF (20)(21)(22)(23), however, only a small number of studies have evaluated the association between other functional VEGF polymorphisms and the incidence rate of RIF (24,25).…”