Vascular Endothelial Growth Factor and Angiogenesis

Synergistic cross‐talk of hedgehog and interleukin‐6 signaling drives growth of basal cell carcinoma

“…Whether the protumorigenic effect of combined HH‐IL6 signaling is directly mediated by the HH‐IL6 targets EDN2, PLAT and NRP1 requires further functional studies. In this context, it is noteworthy that PLAT and NRP1 play a well‐documented role in angiogenesis, in line with previous reports about a putative angiogenic function of IL6 in BCC 45, 46, 47. However, as we did not detect a decrease in CD31 + endothelial cells in Il6ra‐deficient mouse BCC (data not shown), it appears rather unlikely that HH‐IL6 signal integration drives BCC growth by supporting tumor angiogenesis.…”

Sjögren’s syndrome pathological neovascularization is regulated by VEGF-A-stimulated TACE-dependent crosstalk between VEGFR2 and NF-κB

“…2 The pro-angiogenic signal emitted by VEGF-A/VEGFR2 stimulates preexisting endothelial cells and endothelial progenitors to proliferate and differentiate. 7 Angiogenesis is closely regulated by a balanced production of proand anti-angiogenic factors, including growth factors, cytokines, extracellular matrix molecules and metalloproteinases. 6 Metalloproteinases have attracted significant research interest because their inhibitors block angiogenesis in various in vitro and in vivo models.…”

Blood–Brain Barrier Disruption, Vascular Impairment, and Ischemia/Reperfusion Damage in Diabetic Stroke

“…Pericyte‐derived vascular endothelial growth factor (VEGF) may promote BBB disruption after stroke in mice 38. VEGF is an important growth factor for angiogenesis and directly stimulates endothelial cell proliferation and migration 39. Although VEGF is beneficial when administered before stroke40 or at a delayed time point after stroke,41 in the acute phase of stroke, VEGF increases BBB leakage, cerebral hemorrhage, and infarction volume 41.…”