Vascular endothelial growth factor gene is associated with hypertensive cerebellar hemorrhage and rehabilitative treatment

Abstract

ABSTRACT. Early rehabilitative therapy is important for patients with hypertensive cerebral hemorrhage to improve long-term function of the extremities. Vascular endothelial growth factor (VEGF) is closely associated with the pathogenesis of hypertension. To identify the markers contributing to the genetic susceptibility to hypertensive cerebellar hemorrhage (HCH) and rehabilitative treatment, we examined the potential association between HCH and 12 single nucleotide polymorphisms of the VEGF gene. Participants included 244 patients with HCH and 251 healthy controls from our rehabilitation department. The T allelic frequencies of the rs3025020 (intron 6) and rs3025039 (3'-UTR) polymorphisms were significantly higher in the patients with HCH than in the healthy controls (rs3025020 T allele: P = 0.0002, OR = 1.619, 95%CI = 1.256-2.088; rs3025039 T allele: P = 0.001, OR = 1.682, 95%CI = 1.246-2.270). Strong linkage disequilibrium was observed in three blocks (D' > 0.9), and significantly more C-G-C (rs3025020, rs3025030, and rs3025039) haplotypes (P = 0.001) were found in the controls in block 3. Significantly more T-G-C haplotypes were found in the patients with HCH (P = 0.046). Further genotype and clinical phenotype correlation study of the rs3025039 carriers showed that Fugl-Meyer and Barthel index scores were lower in the patients with the TT genotype relative to CT + CC genotypes (P < 0.01). These findings point to a role for VEGF polymorphism in HCH, and may be informative for future investigations on the pathogenesis of rehabilitative treatment.

Polymorphisms in the vascular endothelial growth factor (VEGF) gene associated with asthma

“…The VEGF rs3025039 SNP is not only associated with asthma (Lachheb et al, 2008); like the VEGF rs3025020 polymorphism, rs3025039 is also associated with other diseases, for example, bisphosphonate-related osteonecrosis of the jaw (Choi et al, 2015) and ovarian cancers (Janardhan et al, 2015). Compared with healthy controls, the frequency of the T allele of rs3025039 is significantly higher in patients with HCH (He et al, 2015). This may be because the rs3025020-rs3025039 (block3) has a strong LD.…”

“…The VEGF SNP rs3025020 is located in intron 6 of the VEGF gene and has been reported to be associated with hypertensive cerebellar hemorrhage (HCH) and rehabilitative treatment; individuals who carry the T allele are more susceptible to HCH (He et al, 2015). The rs3025020 polymorphism may increase recurrent spontaneous abortion susceptibility (Almawi et al, 2013).…”

The association between vascular endothelial growth factor gene polymorphisms and stroke

“…There are several evidences that VEGF +936 C/T , −2578 C/A , and −1154 G/A SNPs are associated with the progress of several diseases. [18,29] Although genome-wide association studies on stroke have been published, the results remain controversial, which may be linked with sufficient sample size, appropriate control selection, standardized clinical classification, stroke subtypes, and so on. [3,4]…”

Evaluation of VEGFA gene variants for possible roles in cerebral infarction diseases

“…The VEGFA factor can strengthen neoangiogenesis under those conditions and maintain the blood vessels homeostasis [48] , VEGFA may also mediate the response of increases in permeability and angiogenesis, especially in brain [49] . In the endothelial cells, VEGFA can facilitating cellular migration and sprouting [50] , and also have some roles in cancer pathology, inflammation and wound healing [51,52] .…”