Vascular endothelial growth factor (VEGF) improves the sensitivity of CA125 for differentiation of epithelial ovarian cancers from ovarian cysts

Robati, Minoo; Ghaderi, Abbas; Mehraban, Mitra; Shafizad, Amin; Nasrolahi, Hamid; Mohammadianpanah, Μohammad

doi:10.1007/s00404-013-2819-7

Cited by 12 publications

(8 citation statements)

References 16 publications

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“…The introduction of 3D power Doppler systems can The current study augmented the importance of VEGF as a diagnostic marker for malignancy which agree with many other authors [15][16][17][18][19][20][21][22]. The prognostic importance was mentioned in the literature [2,17].…”

Section: Discussionsupporting

confidence: 86%

Preoperative serum vascular endothelial growth factor correlated to three dimensional power Doppler indices in ovarian masses

AbouSeeda¹,

Mansour²,

Ez-Elarab³

2014

OJOG

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Objective: To assess the preoperative serum levels of vascular endothelial growth factor (VEGF) in ovarian masses compared to normal controls and to find a correlation between VEGF and Doppler indices in ovarian masses. Methods: The study was conducted from December 2009 to September 2012 in the oncology and ultrasound units in department of obstetrics and gynecology, Ain Shams University on 150 patients with ovarian masses. During preoperative workup, serum Ca-125 levels and serum VEGF levels were obtained. Ultrasonographic examination included two and three dimensional power Doppler ultrasound (3DPD). Laparotomic approaches were undertaken to obtain the final pathologic results. VEGF was measured in one hundred normal cases as controls. Results: Final ovarian pathology revealed seventy three malignant ovarian masses and seventy seven were benign. Serum Ca-125 levels in malignant cases were higher compared to those in benign cases (p < 0.001). Preoperative serum VEGF revealed higher levels in malignant ovarian masses than benign conditions and normal controls (p < 0.001). Three dimensional power Doppler indices, vascularization index (VI), flow index (FI) and vascularization flow index (VFI), correlated positively with serum VEGF levels. Conclusion: Preoperative serum VEGF revealed higher levels in malignant ovarian masses than benign conditions and normal controls. These levels positively correlated with the Doppler vascular indices of the masses.

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Section: Discussionsupporting

confidence: 86%

Preoperative serum vascular endothelial growth factor correlated to three dimensional power Doppler indices in ovarian masses

AbouSeeda¹,

Mansour²,

Ez-Elarab³

2014

OJOG

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“…These controversial results may be a consequence of the small samples used in studies. Some data indicate that VEGF may be increased in benign gynecological diseases, such as endometrial hyperplasia, abnormal uterus hemorrhage and ovarian cysts (18, 19). In our study, patients with endometriosis had a significantly higher value of mRNA expression for VEGF compared to patients without endometriosis.…”

Section: Discussionmentioning

confidence: 99%

Survivin and Vegf as Novel Biomarkers in Diagnosis of Endometriosis/ Survivin i vegf kao novi biomarkeri u dijagnostici endometrioze

Aćimović

Vidakovic²,

Milić

et al. 2016

Journal of Medical Biochemistry

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SummaryBackgroundThe aim of this study was to investigate the role of peripheral blood markers as additional diagnostic tools to transvaginal ultrasound (TVU) findings in the diagnosis of endometriosis.MethodsThis study included 40 patients undergoing laparoscopy for suspected endometriosis from January to December 2012. Preoperative levels of serum CA125, CA19-9, CEA and mRNA expression levels for survivin and VEGF were obtained. Real-time PCR was used to determine relative gene expression. A new diagnostic score was obtained by deploying the peripheral blood markers to the TVU findings. Statistical methods used were Chi-square, Fisher’s, Student’s t-test or the Mann – Whitney test.ResultsThere was a statistically significant difference in serum CA125, survivin and VEGF levels in patients with endometriosis and those without endometriosis (p<0.001, p=0.025 and p=0.009, respectively). False negative TVU findings were noted in 3/13 patients (23.1%) with peritoneal endometriosis without ovaries involvement. High sensitivity (93.3%), specificity (90.0%), PPV (96.6%), NPV (81.8%) and accuracy (92.5%) were obtained for a diagnostic score based on TVU and significant peripheral blood markers (CA125, survivin and VEGF).ConclusionsDetermination of serum CA125, mRNA expression levels for survivin and VEGF along with TVU can contribute to higher accuracy of the noninvasive diagnostic tools for endometriosis.

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“…The characteristics of the included studies were shown in Table 1 . 16 – 25 Of ten studies, six studies were conducted in Western countries, and four studies were conducted in Asian countries. Circulating VEGF was measured with enzyme-linked immunosorbent assay (ELISA) in all included studies.…”

Section: Resultsmentioning

confidence: 99%

Circulating VEGF as a biomarker for diagnosis of ovarian cancer: a systematic review and a meta-analysis

Liang¹,

He²,

Zhong³

et al. 2015

OTT

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VEGF is a frequently studied angiogenic factor in ovarian cancer (OC), and is considered to have an important role in the progression of OC. However, its diagnostic value has not been widely accepted because the conclusions are inconsistent and even conflicting. Therefore, we performed a meta-analysis to evaluate the diagnostic value of VEGF in OC. A systematic literature search was conducted using the PubMed, Cochrane Library, EMBASE, Chinese National Knowledge Infrastructure, and WANFANG databases for relevant published articles (the last search update was November 18, 2014). The diagnosis sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and the summary receiver operating characteristic curves were pooled by Meta DiSc 1.4 software. A total of ten studies with 1,131 subjects were finally included in this meta-analysis. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and summary receiver operating characteristic curves were 0.67 (0.63–0.73), 0.78 (0.75–0.81), 3.08 (6.36–12.22), 0.39 (0.29–0.51), 9.10 (5.43–45.25), and 0.8175, respectively. Furthermore, to explore the sources of heterogeneity, we conducted subgroup analyses based on ethnicity and sample size. The diagnostic accuracy of VEGF was higher in an Asian population than in a Caucasian population. A similar finding was found in subgroups with the smaller sample size (<100 subjects). In conclusion, the present meta-analysis suggests that VEGF has moderate diagnostic accuracy for OC. Considering our limitations and the heterogeneity among our selected studies, larger, well-designed prospective and multicenter validation studies are needed to evaluate the diagnostic value of serum VEGF for OC.

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Vascular endothelial growth factor (VEGF) improves the sensitivity of CA125 for differentiation of epithelial ovarian cancers from ovarian cysts

Abstract: This study indicates that the addition of VEGF serum value improves the specificity and the sensitivity of CA125 to detect early stage epithelial ovarian cancers, and to differentiate these neoplasms from ovarian cyst.

Cited by 12 publications

References 16 publications

Preoperative serum vascular endothelial growth factor correlated to three dimensional power Doppler indices in ovarian masses

Preoperative serum vascular endothelial growth factor correlated to three dimensional power Doppler indices in ovarian masses

Survivin and Vegf as Novel Biomarkers in Diagnosis of Endometriosis/ Survivin i vegf kao novi biomarkeri u dijagnostici endometrioze

Circulating VEGF as a biomarker for diagnosis of ovarian cancer: a systematic review and a meta-analysis

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