Vascular FLRT2 regulates venous-mediated angiogenic expansion and CNS barriergenesis
C. Llaó-Cid,
B. Peguera,
P. Kobialka
et al.
Abstract:Veins have emerged as the origin of all other endothelial cell subtypes needed to expand vascular networks during developmental and pathological neoangiogenesis. Here, we uncover the role of the angioneurin Fibronectin Leucine Rich Transmembrane protein (FLRT) 2 in central nervous system (CNS) vascular development in the mouse. Early postnatal FLRT2 deletion reveals specific defects in retinal veins, impacting endothelial cell proliferation, sprouting and polarity that result in reduced tip cells at the vascul… Show more
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