Vascular Inflammation Evaluated by [18F]-Fluorodeoxyglucose Positron Emission Tomography Is Associated With the Metabolic Syndrome

Tahara, Nobuhiro; Kai, Hisashi; Yamagishi, Sho‐ichi; Mizoguchi, Masahiro; Nakaura, Hiroyuki; Ishibashi, Masatoshi; Kaida, Hayato; Baba, Kenkichi; Hayabuchi, Naofumi; Imaizumi, Tsutomu

doi:10.1016/j.jacc.2006.11.046

Cited by 213 publications

(196 citation statements)

References 21 publications

Supporting

Mentioning

174

Contrasting

Unclassified

Order By: Relevance

“…After anecdotal reports, aortic FDG uptake in patients undergoing FDG-PET imaging for oncology staging was described in 2001 [41], and later noted as increasing with age [42], male sex and the presence of vascular risk factors [43][44][45]. In the first prospective clinical study, Rudd et al [46] imaged eight patients shortly after transient ischaemic attack (TIA) with FDG-PET and reported an FDG accumulation rate 27% higher in the symptomatic carotid compared to the contralateral asymptomatic side.…”

Section: Clinical Studies With Fdg-petmentioning

confidence: 99%

“…This has proved important in the search for quantitative measures of inflammation that can be used to test the impact of new therapies. Uptake may be widespread [44,54], although especially affecting the carotid arteries and proximal aorta (Figs 1 and 2). This is consistent with the hypothesis that atherosclerosis is a generalized inflammatory condition.…”

Section: Clinical Studies With Fdg-petmentioning

confidence: 99%

“…Vascular FDG uptake seems to be greater in those subjects with pre-existing metabolic syndrome [44], more than 1 cardiovascular risk factor [54], a history of coronary artery disease or diabetes [54,61]. It rarely co-localizes with vascular calcification [54,62], an independent risk factor for cardiovascular events, perhaps because calcification tends to occur late in the course of the disease, with inflammation earlier.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Vascular imaging with positron emission tomography

Joshi

Rosenbaum

Bordes

et al. 2011

Journal of Internal Medicine

View full text Add to dashboard Cite

Atherosclerosis is an inflammatory disease that causes most myocardial infarctions, strokes and acute coronary syndromes. Despite the identification of multiple risk factors and widespread use of drug therapies, it still remains a global health concern with associated costs. Although angiography is established as the gold standard means of detecting coronary artery stenosis, it does not image the vessel wall itself, reporting only on its consequences such as luminal narrowing and obstruction. MRI and computed tomography provide more information about the plaque structure, but recently positron emission tomography (PET) imaging using [ 18 F]-fluorodeoxyglucose (FDG) has been advocated as a means of measuring arterial inflammation. This results from the ability of FDG-PET to highlight areas of high glucose metabolism, a feature of macrophages within atherosclerosis, particularly in high-risk plaques. It is suggested that the degree of FDG accumulation in the vessel wall reflects underlying inflammation levels and that tracking any changes in FDG uptake over time or with drug therapy might be a way of getting an early efficacy readout for novel anti-atherosclerotic drugs. Early reports also demonstrate that FDG uptake is correlated with the number of cardiovascular risk factors and possibly even the risk of future cardiovascular events. This review will outline the evidence base, shortcomings and emerging applications for FDG-PET in vascular imaging. Alternative PET tracers and other candidate imaging modalities for measuring vascular inflammation will also be discussed.

show abstract

Section: Clinical Studies With Fdg-petmentioning

confidence: 99%

Section: Clinical Studies With Fdg-petmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Vascular imaging with positron emission tomography

Joshi

Rosenbaum

Bordes

et al. 2011

Journal of Internal Medicine

View full text Add to dashboard Cite

show abstract

“…Blood chemistries were measured at our laboratory, using an enzyme-linked immunosorbent assay or an enzymatic assay method as described previously. 10 Glomerular filtration rate was estimated with the Modification of Diet in Renal Disease study equation modified with a Japanese coefficient. 11 Severity of coronary artery stenoses were evaluated by more than 2 experienced interventional cardiologists blinded to the p66 shc data, using quantitative coronary angiography.…”

Section: Data Collectionmentioning

confidence: 99%

The p66^shc Gene Expression in Peripheral Blood Monocytes Is Increased in Patients With Coronary Artery Disease

Noda

Yamagishi

Matsui

et al. 2010

Clinical Cardiology

Self Cite

View full text Add to dashboard Cite

Background: The p66 shc protein has been shown to control cellular responses to oxidative stress, being involved in atherosclerosis in animal models. However, the relationship between the p66 shc gene expression levels and coronary artery disease (CAD) in humans remains unknown. In this study, we examined whether the p66 shc gene expression in peripheral blood monocytes (PBMs) was increased in patients with CAD, compared with age-and sex-matched subjects without CAD. Hypothesis: We hypothesize that the p66 shc gene expression level in PBMs is increased in patients with CAD. Methods: Forty consecutive Japanese subjects who underwent coronary angiography for suspected CAD were enrolled in this study. The p66 shc gene expression levels in PBMs were quantitatively measured by real-time reverse transcription-polymerase chain reactions. Uni-and multivariate analyses were applied for the correlates of CAD. CAD was diagnosed if there was >75% obstruction of at least 1 major coronary artery or a history of percutaneous coronary intervention. Results: There were no significant differences of blood chemistries and clinical characteristics between the patients with and without CAD, except the number of subjects who were on hypertension medication. The p66 shc gene expression levels in PBMs were significantly higher in CAD patients compared with non-CAD subjects. Multiple stepwise regression analysis revealed that the p66 shc gene expression levels and hypertension medication were independently related to CAD (R 2 = 0.287). Further, the p66 shc gene expression levels were significantly increased (P < 0.05) in proportion to the number of diseased vessels. Conclusions:The present study is the first demonstration that increased the p66 shc gene expression in PBMs is independently associated with CAD in Japanese subjects. The p66 shc gene expression level in PBMs may be a novel biomarker of CAD in humans.

show abstract

“…14 18F-FDG uptake is associated with traditional cardiovascular risk factors, including age, male gender and metabolic syndrome, as well as inflammatory biomarkers. 15,16 Moreover, vascular 18F-FDG uptake is elevated in patients infected with human immunodeficiency virus, perhaps accounting for their increased cardiovascular event rate. [17][18][19] A retrospective review of vascular 18F-FDG uptake on PET scans performed in patients with cancer has demonstrated an association between 18F-FDG uptake and subsequent vascular events.…”

mentioning

confidence: 99%

Molecular imaging of the atherosclerotic plaque using positron emission tomography

Toor¹,

Dweck²,

Newby³

2014

J R Coll Physicians Edinb

View full text Add to dashboard Cite

Vascular Inflammation Evaluated by [18F]-Fluorodeoxyglucose Positron Emission Tomography Is Associated With the Metabolic Syndrome

Abstract: ObjectivesWe investigated factors for carotid artery inflammation by [ 18 F]-fluorodeoxyglucose (FDG) positron emission tomography (PET).

Cited by 213 publications

References 21 publications

Vascular imaging with positron emission tomography

Vascular imaging with positron emission tomography

The p66^shc Gene Expression in Peripheral Blood Monocytes Is Increased in Patients With Coronary Artery Disease

Molecular imaging of the atherosclerotic plaque using positron emission tomography

Contact Info

Product

Resources

About

Vascular Inflammation Evaluated by [18F]-Fluorodeoxyglucose Positron Emission Tomography Is Associated With the Metabolic Syndrome

Abstract: ObjectivesWe investigated factors for carotid artery inflammation by [ 18 F]-fluorodeoxyglucose (FDG) positron emission tomography (PET).

Cited by 213 publications

References 21 publications

Vascular imaging with positron emission tomography

Vascular imaging with positron emission tomography

The p66shc Gene Expression in Peripheral Blood Monocytes Is Increased in Patients With Coronary Artery Disease

Molecular imaging of the atherosclerotic plaque using positron emission tomography

Contact Info

Product

Resources

About

The p66^shc Gene Expression in Peripheral Blood Monocytes Is Increased in Patients With Coronary Artery Disease