Vascular Responses in Patients With and Without Diabetes Mellitus After Everolimus-Eluting Stent Implantation

Comprehensive Treatment of Diabetic Patients With Second-Generation Drug-Eluting Stent Implantation

“…In addition, Park et al recently reported that the rates of both TLR (3.6% in DM vs. 1.9% in non-DM, P<0.008) and patient-oriented intravascular ultrasound. 13 In this study, non-significant higher restenosis rate was observed in patients with DM compared with those without (6.9% vs. 1.1%, P=0.09), but there were no significant differences between the 2 groups in the average neointimal thickness. On the contrary, uneven neointimal proliferation was evident in DM, and this phenomenon correlated with asymmetric stent expansion in patients with DM who had more complex coronary lesion morphology, higher plaque volume, and possibly increased arterial stiffness at baseline.…”

Three-Year Clinical Outcomes of Everolimus-Eluting Stents From the Post-Marketing Surveillance Study of Cobalt-Chromium Everolimus-Eluting Stent (XIENCE V/PROMUS) in Japan

“…23 In the present univariate analysis, diabetes with treatment (oral drug or insulin) was one of the significant predictors for 3-year MACE (Table S1), but diabetes did not remain in the multivariate analysis, even though everolimus belongs to the limus family of drugs. 24 For the subgroup analysis in the Randomized Evaluation of Sirolimus-eluting Versus Everolimus-eluting stent Trial (RESET), the cumulative incidence of TLR in patients with insulin-treated diabetes mellitus was significantly lower in the EES group than in the SES group (9.2% vs. 16.1%; P=0.045). 18 Further studies need to be carried out to determine whether this favorable effect in diabetic patients after EES implantation is a chance finding or not.…”

Pioglitazone Increases Circulating MicroRNA-24 With Decrease in Coronary Neointimal Hyperplasia in Type 2 Diabetic Patients – Optical Coherence Tomography Analysis –

“…For qualitative OCT analysis, the peri-strut low-intensity area, which was defined as an area around stent struts that was homogenously hypointense to the surrounding tissue without significant signal attenuation behind the area, neovascularization and the presence of thrombus were evaluated on follow-up OCT. 3 Neovascularization was defined as a small black hole or a tubular structure within a plaque. For the measurement of neointimal unevenness score in each cross-section, the maximal neointimal thickness in 1 cross-section was divided by the average neointimal thickness of the cross-section.…”