Vascularity as assessed by Doppler intraoral ultrasound around the invasion front of tongue cancer is a predictor of pathological grade of malignancy and cervical lymph node metastasis

Yamamoto, Chika; Yuasa, Kenji; Okamura, Kazuhiko; Shiraishi, T; Miwa, Kunihiro

doi:10.1259/dmfr.20150372

Cited by 20 publications

(27 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In humans, ultrasonography has been performed in the investigation of cases with abnormal speech, and for the diagnosis of lingual diseases [6][7][8][9]13]. Application of ultrasonography in lingual diseases of cattle has not been reported, although previous postmortem use for slaughterhouse specimens as a model of human lingual diseases was reported [4].…”

Section: Discussionmentioning

confidence: 99%

“…The venom causes increased capillary permeability, resulting in internal hemorrhages and thromboembolisms associated with damage to the vasculature [12]. Unilateral or bilateral changes to the vascularity of the deep lingual artery due to angiogenesis and changes of vessel width with vessel compression is characteristic of lingual tumors [8,15]. This leads to an imbalance of vascularity and vessel width between the two deep lingual arteries of the tongue [7].…”

Section: Discussionmentioning

confidence: 99%

“…Lingual tumors lead to the formation of nodules within the lingual structures, or protrusions from the lingual membranes in cattle [2]. If ultrasonography is used for these cases, nodular and granulomatous structures would likely be indicated by a well-marginated mass in the muscular fibers aligned irregularly, as in previous human case reports [8,9].…”

Section: Discussionmentioning

confidence: 99%

“…Ultrasonography enables the visualization of the shape, position, and movements of the tongue [6]. In addition, Doppler ultrasonography has been utilized to evaluate the vascularity of lingual cancers and pyogenic granuloma [7][8][9]. The purpose of this case report was (1) to compare the affected tongue with normal tongues based on the blood flow and visual state of the structures, (2) to present the diagnostic process using ultrasonography and the subsequent performance of glossectomy on this bovine case of sudden swelling of the tongue, and (3) to discuss the role of ultrasonography in diagnosis of lingual diseases of cattle based on its prior application in human case reports.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Ultrasonography of sudden swollen tongue in a calf

et al. 2020

View full text Add to dashboard Cite

Background: In cattle, the lingual diseases are primarily diagnosed postmortem by histopathological examination of the affected tongues obtained after the death or during necropsy. In humans, ultrasonography has been used to provide differential diagnoses, and for preoperative or intraoperative planning of glossectomy in various lingual diseases. This is a bovine clinical case report, in which ultrasonography for sudden swelling of the tongue, which was possibly caused by snake bite, was utilized as a preoperative indication to perform a glossectomy. Case presentation: An eight-month-old female Japanese black calf presented with sudden swelling of the tongue with well-defined discoloration in the cranial region. A 10-MHz linear probe on a portable-type ultrasound machine (MyLabOne VET, Esaote Co., Genova, Italy) was applied to the ventral surface of the tongues in the affected case, and also in five healthy calves under sedation to observe normal tongues. Ultrasonography of the swollen tongue in this case revealed that the ventral lingual muscular layers were severely thickened compared with those of normal tongues. However, the muscle layers were regularly aligned with the echogenic muscular fibers. This resembled the lingual muscular architectures of normal tongues. Color-flow Doppler ultrasonography revealed that blood flow was weakened in the small peripheral vessels in the spaces between the lingual muscular structures, and was lacking in the deep lingual artery between the apex and base of the tongue. This finding was very different than that of normal tongues, which exhibited weakened or rich blood flows. Based on ultrasonographic findings, this case was treated with glossectomy. After recovery, the calf grew up normally with a normal appetite and rumination, and did not exhibit mouth pain behavior. Histopathologically, hemorrhagic necrotic changes, together with focal formation of fibrin thrombus in the lingual blood vessels in the affected tongue, were noted. Conclusions: To the best of our knowledge, the present report is the first description of lingual ultrasonography performed in cattle. In this case, ultrasonography enabled visualization of decreased vascularity, which might be associated with hemorrhage or formation of fibrin thrombus in the suddenly swollen tongue presented.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ultrasonography of sudden swollen tongue in a calf

et al. 2020

View full text Add to dashboard Cite

show abstract

“…This study too was based on intra-oral ultrasound imaging [7]. Doppler ultrasound has been found to be very useful in predicting grades of malignancy both in the tumor and cervical lymph nodes [8]. The sublingual approach has also been used before, with positive results.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound imaging of tongue malignancy

Kisansa

Andronikou

2017

IJCRI

View full text Add to dashboard Cite

International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations.IJCRI publishes Review Articles, Case Series, Case Reports, Case in Images, Clinical Images and Letters to Editor. Website: www.ijcasereportsandimages.com Ultrasound imaging of tongue malignancyMargaret Eseza Kisansa, Savvas Andronikou ABSTRACT Introduction: Squamous cell carcinoma of the tongue is a common malignancy associated with risk factors like excessive alcohol consumption, heavy tobacco smoking and human papilloma virus. Magnetic resonance imaging (MRI) scan is considered to be the gold standard in investigating these tumors. However, MRI equipment is expensive to buy and is not readily available in some centers. Computed tomography scan has also been used in imaging these patients but this modality carries a radiation burden. Patient's five-year survival is dependent on early diagnosis. It is, therefore, important to diagnose early and image accurately to ensure good outcomes. Case Series: Two male patients with confirmed carcinoma of the tongue are reported. The first patient was 65-year-old and the second patient was 40-year-old. They both presented with odynophagia. Clinical examination revealed ulcerating lesions involving the base of the tongue. Axial CT scans and ultrasound imaging were performed on these patients through the floor of the mouth. This case report focused on comparing the ability of the two modalities, in delineating margins and depicting tumor thickness. Conclusion: Ultrasound gives excellent information with regards to tumor thickness, margins and vascularity. This highlights the value of using ultrasound as an additional tool in imaging of these patients especially in regions where CT and MRI scans are not readily available.

show abstract

Relationships between intraoral ultrasonographic and histopathological findings in patients with tongue cancer

et al. 2021

View full text Add to dashboard Cite

Background In this study, we aimed to investigate the relationships between histopathological and intraoral ultrasonographic (IUS) findings in patients with tongue cancer. Methods IUS and histopathological findings in 46 patients with tongue cancer were considered for this study. We assessed the relationships between IUS findings regarding tumor thickness, margin type, border type, and internal echo intensity; internal/peripheral Doppler findings; and muscle invasion and histopathological findings regarding tumor thickness, differentiation, Yamamoto–Kohama (YK)‐classification grade, blood vessel invasion, lymphatic invasion, perineural invasion, and muscle invasion. Results Statistical associations were found between the following findings: between thickness determined through IUS measurement and that determined through histopathological measurement, between the IUS findings regarding tumor margin and border types and the histopathologically determined YK‐classifications grades, and between a Doppler image of the internal area of tongue lesions and lymphatic invasion. Conclusions IUS findings may be used to predict histopathological findings about tumor thickness and YK‐classification grades.

show abstract

Vascularity as assessed by Doppler intraoral ultrasound around the invasion front of tongue cancer is a predictor of pathological grade of malignancy and cervical lymph node metastasis

Cited by 20 publications

References 26 publications

Ultrasonography of sudden swollen tongue in a calf

Ultrasonography of sudden swollen tongue in a calf

Ultrasound imaging of tongue malignancy

Relationships between intraoral ultrasonographic and histopathological findings in patients with tongue cancer

Contact Info

Product

Resources

About