Vasculogenic Erectile Dysfunction: The Impact of Diet and Lifestyle

Ostfeld, Robert J.; Allen, Kathleen; Aspry, Karen; Brandt, Eric; Spitz, Aaron; Liberman, Joshua N.; Belardo, Danielle; O’Keefe, James H.; Aggarwal, Monica; Miller, Michael; Batiste, Columbus; Kopecky, Stephen L.; White, Beth; Shah, Nikhil; Hawamdeh, Hussam; Batts, Travis; Blankstein, Ron; Reddy, Koushik; Ornish, Dean; Freeman, Andrew M.

doi:10.1016/j.amjmed.2020.09.033

Cited by 30 publications

(26 citation statements)

References 61 publications

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“…However, daily aspirin therapy is associated with enhanced bleeding risks, which raises the question of whether a dietary antiplatelet could be similarly successful. It is already known that diet and lifestyle impact ED and that altering nutritional factors can have beneficial effects [ 80 ]. In fact, diets close to the Mediterranean diet profile (including high tomato intake) are associated with a reduced burden of ED [ 81 ].…”

Section: Emerging Areas Of Interest For Dietary Antiplateletsmentioning

confidence: 99%

Dietary Antiplatelets: A New Perspective on the Health Benefits of the Water-Soluble Tomato Concentrate Fruitflow®

O’Kennedy

Duss²,

Duttaroy

2021

Nutrients

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Our understanding of platelet functionality has undergone a sea change in the last decade. No longer are platelets viewed simply as regulators of haemostasis; they are now acknowledged to be pivotal in coordinating the inflammatory and immune responses. This expanded role for platelets brings new opportunities for controlling a range of health conditions, targeting platelet activation and their interactions with other vascular cells. Antiplatelet drugs may be of wider utility than ever expected but often cause platelet suppression too strong to be used out of clinical settings. Dietary antiplatelets represent a nutritional approach that can be efficacious while safe for general use. In this review, we discuss potential new uses for dietary antiplatelets outside the field of cardiovascular health, with specific reference to the water-soluble tomato extract Fruitflow®. Its uses in different aspects of inflammation and immune function are discussed, highlighting exercise-induced inflammation, mediating the effects of air pollution, and controlling thrombotic aspects of the immune response. Potential future developments in women’s health, erectile dysfunction, and the allergic response indicate how broad the utility of dietary antiplatelets can be.

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Section: Emerging Areas Of Interest For Dietary Antiplateletsmentioning

confidence: 99%

Dietary Antiplatelets: A New Perspective on the Health Benefits of the Water-Soluble Tomato Concentrate Fruitflow®

O’Kennedy

Duss²,

Duttaroy

2021

Nutrients

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“…LUTS are commonly reported using the International Prostate Symptom Score (IPSS) which is an 8-question written screening tool developed in 1992 by the American Urological Association (AUA), for both the initial evaluation of BPH and monitoring treatment efficacy [9]. The survey is practical in that it both quantitatively analyzes symptoms of BPH and enables patients to disclose symptoms with a degree of privacy, as it is almost always self-administered.…”

Section: Screening Literacy and Community Interventionmentioning

confidence: 99%

“…It contains seven questions related to BPH symptoms and one question related to the patient's perceived quality of life. BPH symptom severity is proportionate to the IPSS score, which ranges from 0 to 35 and categorizes symptoms as mild (1-7), moderate (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19), or severe (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35). The IPSS survey is widely used in Urology and the AUA also encourages its use in primary care settings.…”

Section: Screening Literacy and Community Interventionmentioning

confidence: 99%

“…A 2020 study utilizing the Healthcare Cost and Utilization Project State Emergency Department Databases in Florida between 2005 and 2015 showed that African Americans are at increased risk for presentation to the ED for acute urinary retention (OR 1.15, P<0.001) [8]. The observed risk for acute urinary retention was even greater for Hispanics (OR 1.75, p<0.001) [9]. Given the likelihood that acute urinary retention is often caused by progressed and inadequately treated BPH, the results of this study support the likelihood that patients in these racial groups are relatively underdiagnosed and/or undertreated for BPH relative to white populations.…”

Section: Introductionmentioning

confidence: 99%

“…The failure to appropriately address BPH in African Americans is concerning on a myriad of levels, especially given the abundant evidence that this disease is linked to broader health conditions including cardiovascular disease [1,6,9]. A recent study in 2019 showed that African American men aged 35-49 with uncontrolled hypertension are 56% more likely to have nocturia compared to African American men in the same age group with normotension [10].…”

Section: Introductionmentioning

confidence: 99%

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Benign Prostatic Hyperplasia in African American Men Merits Greater Consideration in Academic Medicine

Wiedemer¹

2021

AABSc

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Benign Prostatic Hyperplasia (BPH) is a non-cancerous enlargement of the prostate gland, which is highly prevalent in aging men. This process of benign prostate enlargement is known to occur more rapidly in African American men, which has resulted in a disproportionately increased prevalence relative to the general population. In the United States, the cause of this disproportionately increased risk in African Americans is believed to be due to both genetic factors as well as a complex myriad of variables related to health disparities. Despite a robust increase in research related to prostate cancer in African American men, the issue of BPH/LUTS in the African American community deserves equally increased attention in academic medicine. The purpose of this article is to provide a brief review of the medical literature on BPH/LUTS in the African American community to highlight unknown components of the disease and to demonstrate the need for more equitable urologic healthcare.

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