Vasoactive intestinal peptide, a singlet oxygen quencher.

Misra, Bibhu R.; Misra, Hara P.

doi:10.1016/s0021-9258(18)55404-1

Cited by 69 publications

(6 citation statements)

References 24 publications

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“…Previous studies indicated that some other ROS (such as singlet oxygen and hydroxyl radical) can derive from superoxide anions. 32,33 Our current results based on superoxide anion production suggest that although trace amount of ROS may be produced, it plays a minor role in the antibacterial activity of graphene-based materials. Nevertheless, the production and impact of different possible ROS should be carefully examined in future studies.…”

Section: Resultsmentioning

confidence: 71%

Antibacterial Activity of Graphite, Graphite Oxide, Graphene Oxide, and Reduced Graphene Oxide: Membrane and Oxidative Stress

Liu

Zeng²,

Hofmann³

et al. 2011

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Health and environmental impacts of graphene-based materials need to be thoroughly evaluated before their potential applications. Graphene has strong cytotoxicity toward bacteria. To better understand its antimicrobial mechanism, we compared the antibacterial activity of four types of graphene-based materials (graphite (Gt), graphite oxide (GtO), graphene oxide (GO), and reduced graphene oxide (rGO)) toward a bacterial model-Escherichia coli. Under similar concentration and incubation conditions, GO dispersion shows the highest antibacterial activity, sequentially followed by rGO, Gt, and GtO. Scanning electron microscope (SEM) and dynamic light scattering analyses show that GO aggregates have the smallest average size among the four types of materials. SEM images display that the direct contacts with graphene nanosheets disrupt cell membrane. No superoxide anion (O(2)(•-)) induced reactive oxygen species (ROS) production is detected. However, the four types of materials can oxidize glutathione, which serves as redox state mediator in bacteria. Conductive rGO and Gt have higher oxidation capacities than insulating GO and GtO. Results suggest that antimicrobial actions are contributed by both membrane and oxidation stress. We propose that a three-step antimicrobial mechanism, previously used for carbon nanotubes, is applicable to graphene-based materials. It includes initial cell deposition on graphene-based materials, membrane stress caused by direct contact with sharp nanosheets, and the ensuing superoxide anion-independent oxidation. We envision that physicochemical properties of graphene-based materials, such as density of functional groups, size, and conductivity, can be precisely tailored to either reducing their health and environmental risks or increasing their application potentials.

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Section: Resultsmentioning

confidence: 71%

Antibacterial Activity of Graphite, Graphite Oxide, Graphene Oxide, and Reduced Graphene Oxide: Membrane and Oxidative Stress

Liu

Zeng²,

Hofmann³

et al. 2011

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“…Carcinogenesis, aging, and oxygen toxicity appear to be linked to 1 O 2 interactions with biological molecules [38]. The ability of a vasoactive intestinal peptide, histidine-containing peptides (histidine at C terminal), to quench 1 O 2 has been documented.…”

Section: Inhibitory Activity Against Ros (Ohmentioning

confidence: 99%

Characterization of Antioxidant Peptides from Thai Traditional Semi-Dried Fermented Catfish

et al. 2021

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Herein, the antioxidant peptides from a Thai traditional semi-dried fermented farmed hybrid catfish (Clarias macrocephalus × Clarias gariepinus) catfish, Pla Duk Ra, were characterized. After extraction and deproteinization, Pla Duk Ra crude peptide extract (CPE) was fractioned using 2 connected Hitrap Sephadex-G25 columns, yielding two significant fractions, F1 with higher browning intensity (A420) and F2. CPE, F1, and F2 had different amino acid profiles, contents, and sequences evaluated by LC-MS/MS, which could be responsible for their antioxidant properties. F2 contained the highest numbers of hydrophobic amino acid (HBA) (47.45%) and aromatic amino acid (27.31%), followed by F1, and CPE. The peptides with 8–24 amino acid residues were detected in CPE and its fractions. In CPE, F1, and F2, there were 69, 68, and 85 peptides with varied HBA content, respectively. ARHSYGMLYCSCPPND (50% HBA), ALRKMGRK (37.5% HBA), and ANWMIPLM (87.5% HBA) were the most prevalent peptides found in CPE, F1, and F2. Overall, F2 was the most effective at inhibiting free radicals (DPPH● and ABTS●+) and reactive oxygen species (hydroxyl radical, singlet oxygen, and hydrogen peroxide), followed by F1 and CPE. The metal chelation of F1 was, however, superior to that of F2 and CPE. For the stability test, the effects of pH, heating temperature, and in vitro digestion on the DPPH● scavenging activity of F2 were investigated. The activity was boosted by lowering the pH and raising the heating temperature. In the gastrointestinal tract model system, however, roughly 50% of DPPH● scavenging activity reduced after digesting.

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“…Superoxide Radical Anion. 18,19 The A549 cancer cells (5 × 10 3 cells per well in a 96-well culture plate) were seeded into ICG and all Au nanomaterials for overnight of incubation in the dark at 37 °C with 5% CO 2 in air. After they had been incubated, the mixture exposed to nonlinear laser in the dark.…”

Section: = × Amt Of Targeting and Internalized Au Amt Of Au Nps Sampl...mentioning

confidence: 99%

Effect of Size-Dependent Photodestructive Efficacy by Gold Nanomaterials with Multiphoton Laser

Chang

Chen

Chang

et al. 2015

ACS Appl. Mater. Interfaces

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The photostability, photodestructive efficacy, two-photon excitation cross section, and two-photon fluorescence of gold nanoparticles conjugated with a hydrophilic photosensitizer, indocyanine green, via multiphoton laser exhibited an increased size effect in methicillin-resistant Staphylococcus aureus and A549 cancer cells that was dependent on the size of multifunctional gold nanomaterials, but the effect only occurred when nanomaterials within 100 nm in diameter were used. Besides, the enhanced effectiveness of photodestruction, photostability, and contrast probe indicated an additive effect in the therapeutic and imaging efficiency of multifunctional gold nanomaterials. Consequently, the preparation of the multifunctional gold nanomaterials and their use in biomedical applications via multiphoton laser is an alternative and potential therapeutic approach for killing bacteria and for ablating cancer cells.

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Vasoactive intestinal peptide, a singlet oxygen quencher.

Cited by 69 publications

References 24 publications

Antibacterial Activity of Graphite, Graphite Oxide, Graphene Oxide, and Reduced Graphene Oxide: Membrane and Oxidative Stress

Antibacterial Activity of Graphite, Graphite Oxide, Graphene Oxide, and Reduced Graphene Oxide: Membrane and Oxidative Stress

Characterization of Antioxidant Peptides from Thai Traditional Semi-Dried Fermented Catfish

Effect of Size-Dependent Photodestructive Efficacy by Gold Nanomaterials with Multiphoton Laser

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