Vasoactive intestinal polypeptide receptor VPAC1 subtype is predominant in rat prostate membranes

Juarranz, Marı́a G.; Neef, Philippe De; Robberecht, Patrick

doi:10.1002/(sici)1097-0045(19990915)41:1<1::aid-pros1>3.0.co;2-a

Cited by 16 publications

(9 citation statements)

References 33 publications

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“…In other tissues, besides the stimulation of cAMP production, the PAC 1 receptor increased the inositol phosphate production [16]. However, rat prostatic glands express mainly VPAC 1 receptors positively coupled to adenylate cyclase [19]. In the present study, we have shown that VIP is able to stimulate rat prostatic epithelial cell proliferation in culture by a cAMP-dependent mechanism.…”

Section: Discussionsupporting

confidence: 49%

“…VIP, PACAPs, gastrin releasing peptide (GRP), calcitonin, or serotonin induce androgen-independent growth in human prostate cancer cells [27,28], and therefore can play an important role in the progression of prostatic cancer that is insensitive to androgen deprivation therapy. There are few studies about the role of VIP in the growth of normal prostate, in spite of the high expression of VIP receptors positively coupled to adenylate cyclase [19] and their putative role in the development of rat prostate [9] and in prostate epithelial cell differentiation [15].…”

Section: Discussionmentioning

confidence: 99%

“…The amino acid sequences in the N-terminal portion of PAC 1 and VPAC 1 /VPAC 2 receptors show great differences that are responsible for the increased selectivity for PACAP in the PAC 1 receptors [17]. Recently, a major presence of VPAC 1 receptors has been described in human prostate tumors and rat prostate [18,19]. In human benign hyperplastic prostate (BPH), the presence of common VIP/PACAP and speci®c PAC 1 receptors coupled to the stimulation of adenylate cyclase activity has been demonstrated [20,21].…”

Section: Introductionmentioning

confidence: 99%

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Vasoactive intestinal peptide (VIP) stimulates rat prostatic epithelial cell proliferation

et al. 2001

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BACKGROUND. Androgens play a major role in supporting normal growth and functional maintenance in the prostate. However, this gland contains an array of neuroendocrine peptides that can play a regulatory role in its physiopathology. Among these peptides, one of the best studied is vasoactive intestinal peptide (VIP), which is abundant in autonomic nerves surrounding both human and rat prostatic acini. This neuropeptide may act through interaction with two types of high-af®nity receptors, named VPAC 1 and VPAC 2 receptors. Another regulatory peptide, the pituitary adenylate cyclase-activating peptide (PACAP), interacts with these receptors with the same af®nity as VIP, but binds with higher af®nity to PAC 1 receptors. Human prostate tumors and rat prostate show a major presence of VPAC 1 receptors, whereas various ®ndings suggest a role for VIP in prostatic development. Here we studied the effects of VIP on the proliferation of rat prostatic epithelial cells in culture. METHODS. We studied the [ 3 H]-thymidine uptake by rat prostatic epithelial cells in culture, characterized previously by using biomarkers such as cytokeratin and vimentin. In these cells we tested the effect of VIP and PACAP-27 on two different signaling pathways, the cyclic AMP (cAMP) and the inositol phosphate (IPs). RESULTS. The rat prostatic cells in culture were cytokeratin (5,6,8) and vimentin positive, indicating that the culture was predominantly epithelial. The proliferation curves showed that the cells followed different states of growth: a quiescent, an exponential proliferative, and a steady state. Cyclic AMP production, but not inositol phosphate production, was increased in the presence of VIP and PACAP-27, which suggests the expression of VPAC 1 and/or VPAC 2 receptors primarily. VIP signi®cantly increased prostatic cell proliferation in a bimodal manner, as shown for dibutyryl cyclic AMP (dbcAMP), which suggests that the effect of VIP upon prostatic proliferation is cAMP-dependent. CONCLUSIONS. Here, we demonstrate that VIP increased [ 3 H]thymidine uptake by rat prostatic epithelial cells in culture, conceivably by the activation of the adenylate cyclase.

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Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Vasoactive intestinal peptide (VIP) stimulates rat prostatic epithelial cell proliferation

et al. 2001

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“…Spermatids contain both PAC1-R and VPAC2-R (Li et al, 2004). In the healthy and tumoral prostate, all PACAP receptors are expressed (Juarranz et al, 1999;Solano et al, 1999;García-Ferná ndez et al, 2003).…”

Section: F Distribution Of Pituitary Adenylate Cyclaseactivating Polmentioning

confidence: 99%

Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery

Vaudry

Falluel‐Morel

Bourgault

et al. 2009

Pharmacological Reviews

1,172

1,610

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“…Receptors for VIP have been found in the prostate; 81 however due to their glandular distribution, VIP does not appear to be involved in contraction and instead may have roles in secretion or prostatic growth 82 …”

Section: Innervation Of the Adult Prostate Glandmentioning

confidence: 99%

Age-related changes in the innervation of the prostate gland

2013

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The adult prostate gland grows and develops under hormonal control while its physiological functions are controlled by the autonomic nervous system. The prostate gland receives sympathetic input via the hypogastric nerve and parasympathetic input via the pelvic nerve. In addition, the hypogastric and pelvic nerves also provide sensory inputs to the gland. This review provides a summary of the innervation of the adult prostate gland and describes the changes which occur with age and disease. Growth and development of the prostate gland is age dependent as is the occurrence of both benign prostate disease and prostate cancer. In parallel, the activity and influence of both the sympathetic and parasympathetic nervous system changes with age. The influence of the sympathetic nervous system on benign prostatic hyperplasia is well documented and this review considers the possibility of a link between changes in autonomic innervation and prostate cancer progression.

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Vasoactive intestinal polypeptide receptor VPAC1 subtype is predominant in rat prostate membranes

Cited by 16 publications

References 33 publications

Vasoactive intestinal peptide (VIP) stimulates rat prostatic epithelial cell proliferation

Vasoactive intestinal peptide (VIP) stimulates rat prostatic epithelial cell proliferation

Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery

Age-related changes in the innervation of the prostate gland

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