Vasoconstrictive effect of bile acids on isolated human placental chorionic veins

Sepúlveda, Waldo; González, Claudio; Cruz, Maria Antonieta; Rudolph, M I

doi:10.1016/0028-2243(91)90222-7

Cited by 213 publications

(112 citation statements)

References 17 publications

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“…Reasons for fetal distress and placental abruption as well many of the other adverse effects are thought be the effects of bile acids on the placenta. Studies have indicated that bile acids can cause placenta vasoconstriction [22] and affect the placental transport and hormone production. In addition bile acids have been shown to increase myometrial sensitivity to oxytocin in humans and cause colonic contraction in animal fetuses increasing the passage of meconium [18].…”

Section: Discussionmentioning

confidence: 99%

Presence of Obstetrics Cholestasis in Mothers Presenting with Pruritus in Pregnancy: In a Low Resource South Asian Setting

Dodampahala¹,

Pieris²,

Chandrasena³

et al. 2016

ARSci

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Obstetric cholestasis (also referred to as intrahepatic cholestasis of pregnancy-ICP) is a pruritic form of reversible cholestasis that is associated with significant fetal risks. There is a paucity of research regarding pregnancy outcomes of the mothers with obstetric cholestasis in the South Asian setting. Hence, the objective of this study was to determine the prevalence of obstetric cholestasis among mothers presenting with pruritus during pregnancy and to describe the characteristics and outcomes for those diagnosed with ICP in comparison with those with pruritus in the absence of ICP. Methods: All mothers presenting with pruritus to De Soyza Maternity hospital in Colombo Sri Lanka, between 1st January 2011 to 1st January 2014, were recruited for the study. A standard set of biochemical tests were used for diagnosis of ICP. An interviewer administered questionnaire and patient records were used for data collection. Presentation, characteristics and pregnancy outcomes were assessed and compared for mothers with ICP against those with pruri-

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Section: Discussionmentioning

confidence: 99%

Presence of Obstetrics Cholestasis in Mothers Presenting with Pruritus in Pregnancy: In a Low Resource South Asian Setting

Dodampahala¹,

Pieris²,

Chandrasena³

et al. 2016

ARSci

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“…12 An in vitro study suggests that biliary acids may have a vasoconstrictive effect on the placental cotyledons. 13 Another in vitro study using cultured cardiomyocites has shown that the bile acid taurocholate impairs rat cardiomyocyte function via altered calcium dynamics and loss of synchronous beating.…”

Section: Discussionmentioning

confidence: 99%

A randomised controlled trial of ursodeoxycholic acid and S‐adenosyl‐l‐methionine in the treatment of gestational cholestasis

Roncaglia

Locatelli

Arreghini

et al. 2003

BJOG

108

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Objective To compare the efficacy of S-adenosyl-L-methionine and ursodeoxycholic acid in improving serum biochemical abnormalities in gestational cholestasis. Design Randomised clinical trial.Setting University hospital.Population All women at <36 weeks of gestation with severe gestational cholestasis during June 1996 to December 2001. Methods Enrolled women were randomly assigned oral S-adenosyl-L-methionine 500 mg twice daily or oral ursodeoxycholic acid 300 mg twice daily until delivery. Main outcome measures Reduction in the concentration of serum bile acids. Other variables considered included obstetric and neonatal outcome, clinical symptoms and other laboratory measurements (serum levels of transaminases and bilirubin). The two groups were compared using Student's t test, Wilcoxon's signed rank sum test and Fisher's exact test, with a two-tailed P < 0.05 being considered significant. Results Of the 46 women enrolled, 24 received ursodeoxycholic acid and 22 S-adenosyl-L-methionine. At enrolment, gestational age, duration of therapy, rate of nulliparity, pruritus score and biochemical characteristics were similar between the groups. Both therapies significantly and equally improved pruritus. Women receiving ursodeoxycholic acid had a significantly greater improvement in the concentration of serum bile acids ( P ¼ 0.001), aspartate aminotransferase ( P ¼ 0.01), alanine aminotransferase (<0.001) and bilirubin ( P ¼ 0.002) compared with those receiving S-adenosyl-L-methionine. Duration of therapy was significantly greater in women receiving ursodeoxycholic acid compared with S-adenosyl-Lmethionine ( P ¼ 0.04), whereas gestational age at delivery and rate of prematurity were similar in the two groups. Conclusions In women with intrahepatic cholestasis of pregnancy, ursodeoxycholic acid is more effective than S-adenosyl-L-methionine at improving the concentration of serum bile acids and other tests of liver function, whereas both therapies are equally effective at improving pruritus.

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“…Clancy et al (2007) showed that hypoxia is thought to contribute to differentiation of human fetal cardiac fibroblasts into myofibroblasts in vitro (Clancy et al, 2007). It has also been postulated that fetal death in ICP may be mediated by bile acid induced vasoconstriction of placental vessels leading to acute hypoxia in these fetuses (Mays, 2010;Sepúlveda et al, 1991). A study by Miragoli et al (2011a) showed that myofibroblasts transiently appear in human fetal ventricular tissue during the second and third trimesters of gestation.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

The protective effect of ursodeoxycholic acid in an in vitro model of the human fetal heart occurs via targeting cardiac fibroblasts

Schultz

Hasan

Alvarez-Laviada

et al. 2016

Progress in Biophysics and Molecular Biology

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Vasoconstrictive effect of bile acids on isolated human placental chorionic veins

Cited by 213 publications

References 17 publications

Presence of Obstetrics Cholestasis in Mothers Presenting with Pruritus in Pregnancy: In a Low Resource South Asian Setting

Presence of Obstetrics Cholestasis in Mothers Presenting with Pruritus in Pregnancy: In a Low Resource South Asian Setting

A randomised controlled trial of ursodeoxycholic acid and S‐adenosyl‐l‐methionine in the treatment of gestational cholestasis

The protective effect of ursodeoxycholic acid in an in vitro model of the human fetal heart occurs via targeting cardiac fibroblasts

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