Vasoformative Lesions in Mediastinal Mixed Germ Cell Tumors: an Interesting Account of Two Cases Spanning the Benign to Malignant Spectrum

Bakshi, Neha; Bishnoi, Sukhram; Rao, Seema

doi:10.1007/s13193-018-0778-y

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…Their cases of 55 patients were associated with yolk sac tumour components, and all specimens were analyzed after chemotherapy. A few similar cases have been published previously, associated with PMTERs independent of prior chemotherapy 142–145 . Recently, a case report also showed a VMT combined with a PMSEMs without prior chemotherapy 146 .…”

Section: Pmgcts With Somatic‐type Solid Malignanciesmentioning

confidence: 65%

“…A few similar cases have been published previously, associated with PMTERs independent of prior chemotherapy. [142][143][144][145] Recently, a case report also showed a VMT combined with a PMSEMs without prior chemotherapy. 146 VMT consists of neoplastic vascular and stromal components that show different grades of atypia in both components (low-and high-grade VMT).…”

Section: Pmgcts With Somatic-type Solid Malignanciesmentioning

confidence: 99%

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Primary germ cell tumours of the mediastinum: A review with emphasis on diagnostic challenges

Fichtner,

Marx,

Ströbel

et al. 2023

Histopathology

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This article will review current aspects of the histopathological, immunohistochemical and molecular analysis of primary mediastinal germ cell tumours (PMGCTs) as well as their aetiological, epidemiological, clinical and therapeutic features. PMGCTs represent an important differential diagnosis in the spectrum of mediastinal tumours, and their diagnosis is usually made on small tissue samples from core needle biopsies in combination with diagnostic imaging and serum tumour markers. As in lymphomas, a small biopsy is often the only viable tumour sample available from these patients, as they receive chemotherapy prior to eventual surgical resection. Pathologists therefore need to apply an efficient combination of immunohistochemical markers to confirm the diagnosis of a PMGCT and to exclude morphological mimics.

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Section: Pmgcts With Somatic‐type Solid Malignanciesmentioning

confidence: 65%

Section: Pmgcts With Somatic-type Solid Malignanciesmentioning

confidence: 99%

Primary germ cell tumours of the mediastinum: A review with emphasis on diagnostic challenges

Fichtner,

Marx,

Ströbel

et al. 2023

Histopathology

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Mediastinal mixed germ cell tumor: A case report and literature review

Xia

et al. 2021

Open Medicine

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Mixed germ cell tumor (MGCT) mainly occurs in young women’s ovaries and men’s testicles and rarely occurs outside the gonad. Fewer than 10 cases of mediastinal MGCT are available in PubMed, Embase, and other databases in English, while mediastinal MGCT with three pathological components, such as yolk sac tumor, immature teratoma, and embryonal carcinoma, has not been reported previously. A 12-year-old male sought medical attention for chest discomfort and underwent a computed tomography (CT) scan. A large soft tissue mass occupying most of the left thoracic cavity and mediastinum was detected. A CT-guided biopsy was performed, and an MGCT was diagnosed with pathological components, including yolk sac tumor, immature teratoma, and a small amount of embryonal carcinoma. Due to the large size of the tumor, the patient was treated with an EP regimen (etoposide + cisplatin) and paclitaxel + ifosfamide + cisplatin interstitial chemotherapy. The patient was followed up for 6 months and was alive with the disease. To the best of our knowledge, this is the 10th patient with MGCT in the mediastinum. The incidence of mediastinal MGCT is low, but it should still be considered one of the differential diagnoses of isolated pleural fibroma and neurogenic tumors.

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Pediatric mediastinal germ cell tumors

Kakkar¹,

Kaur²,

Verma³

2019

Mediastinum

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Mediastinal germ cell tumors (GCTs) are a rare and heterogeneous group of neoplasms. Although histologically resembling their gonadal counterparts, they differ considerably in their clinical characteristics, biological behavior and prognostic outcome. The rarity of mediastinal GCTs has hindered their meaningful analysis, with most studies and clinical trials including them along with other extragonadal GCTs, which has led to a lack of consensus on optimal treatment strategies, and a lull in improvement in patient outcomes. Diagnosis of mediastinal GCT requires a multipronged approach, and encompasses multidisciplinary treatment including chemotherapy followed by surgery, with or without radiotherapy. In view of sustained response rates to current management protocols, the focus needs to be shifted to identifying patients in whom treatment regimens can be downscaled with the aim of decreasing long term morbidity and improving quality of life in low risk patient groups, while improving survival rates in poor risk patient subsets. In this scenario, better understanding of the molecular pathogenesis of these tumors may lead to identification of novel biomarkers and therapeutic targets, as well as improved disease segmentation and risk stratification, thus helping to avoid the toxicity and morbidity associated with current one-fits-all treatment strategies. Multi-institutional collaborations across continents are necessary to generate meaningful data, and are the face of future developments in this arena.

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Vasoformative Lesions in Mediastinal Mixed Germ Cell Tumors: an Interesting Account of Two Cases Spanning the Benign to Malignant Spectrum

Cited by 3 publications

References 8 publications

Primary germ cell tumours of the mediastinum: A review with emphasis on diagnostic challenges

Primary germ cell tumours of the mediastinum: A review with emphasis on diagnostic challenges

Mediastinal mixed germ cell tumor: A case report and literature review

Pediatric mediastinal germ cell tumors

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