2021
DOI: 10.3390/biomedicines9121774
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Vasomotor Dysfunction in Patients with Ischemia and Non-Obstructive Coronary Artery Disease: Current Diagnostic and Therapeutic Strategies

Abstract: Many patients who present with symptoms or objective evidence of ischemia have no or non-physiologically-significant disease on invasive coronary angiography. The diagnosis of ischemic heart disease is thus often dismissed, and patients receive false reassurance or other diagnoses are pursued. We now know that a significant proportion of these patients have coronary microvascular dysfunction and/or vasospastic disease as the underlying pathophysiology of their clinical presentation. Making the correct diagnosi… Show more

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“…Coronary artery plaque burden and particular high-risk plaque features like non-calcified plaque, microcalcification and positive remodelling by coronary computed tomography angiography (CCTA) have been demonstrated to predict myocardial ischemia and risk of cardiovascular (CV) events [2] , [9] . Non-invasive or invasive functional testing to directly assess intracoronary flow reserve or microvascular resistance have also been suggested to improve detection of myocardial ischemia and CV risk among patients with non-obstructive CAD [10] . Currently, investigation of patients with non-obstructive CAD is time-consuming, associated with risk of complications and hence is difficult to implement into clinical practise.…”
Section: Introductionmentioning
confidence: 99%
“…Coronary artery plaque burden and particular high-risk plaque features like non-calcified plaque, microcalcification and positive remodelling by coronary computed tomography angiography (CCTA) have been demonstrated to predict myocardial ischemia and risk of cardiovascular (CV) events [2] , [9] . Non-invasive or invasive functional testing to directly assess intracoronary flow reserve or microvascular resistance have also been suggested to improve detection of myocardial ischemia and CV risk among patients with non-obstructive CAD [10] . Currently, investigation of patients with non-obstructive CAD is time-consuming, associated with risk of complications and hence is difficult to implement into clinical practise.…”
Section: Introductionmentioning
confidence: 99%