Vasomotor Function After Paclitaxel-Coated Balloon Post-Dilation in Porcine Coronary Stent Model

Abstract

Post-dilation of bare-metal stents with PCB was associated with impaired vasodilatory response to Ach distal to the treated segments. Vasodilatory response after post-dilation with non-DCB was similar to control arteries.

Influence of a paclitaxel coated balloon in combination with a bare metal stent on restenosis and endothelial function: Comparison with a drug eluting stent and a bare metal stent

“…These results question the results of earlier trials indication a negative effect of DES on endothelial and microvascular function . Furthermore, we did not see an impaired vasodilatory response to acetylcholine distal to the treated segments, which has been reported in a porcine study by DCB . However, it has to be taken in account that most of these trials including our own suffer from modest sample sizes.…”

“…Different approaches of local intravascular drug delivery may influence endothelial and microvascular function. Preclinical reports show conflicting data on the influence of short time paclitaxel application on vasomotion and endothelial function . Therefore, the aim of this clinical trial was to study the influence of BMS mounted on a paclitaxel coated balloon (DCB + BMS) versus a BMS or a sirolimus‐eluting stent (DES) on coronary restenosis and endothelial function.…”

No-Reflow Phenomenon During Treatment of Coronary In-Stent Restenosis With a Paclitaxel-Coated Balloon Catheter

“…One possible explanation of no-reflow after DEB angioplasty is related to paclitaxel. A recent study of paclitaxel-coated balloons in a porcine model showed that the paclitaxel-coated balloon is associated with impaired vasodilatory responses to acetylcholine distal to the treated segments 7). The other possible explanation is related to the coating.…”

Macromolecular Approaches to Prevent Thrombosis and Intimal Hyperplasia Following Percutaneous Coronary Intervention

“…63 Two of the main strategies for local delivery from balloons have occurred via elution of drug solution from porous balloon catheters 64−66 and drug-coated balloons. 62,67,68 Porous balloons are able to directly transfer drugs to the adjacent vessel wall using inflation pressure, which forces the solution from the balloon lumen to the tissue of the vessel wall; however, a delicate balance between sufficient pressure to deliver agents into the wall of the vessel, yet prevent mechanical wall damage must be achieved. 64,65,69,70 The use of drug-coated balloons presents another strategy for local delivery.…”