Vasovagal reactions in apheresis donors

Tomita, Tadao; Takayanagi, Miyuki; Kiwada, Kimie; Mieda, Akemi; Takahashi, Chiyoko; Hata, Tadayoshi

doi:10.1046/j.1537-2995.2002.00241.x

Cited by 56 publications

(64 citation statements)

References 13 publications

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“…Most of the vascular injuries were committed by the relatively inexperienced newly joined staff nurses or the technical staffs in the apheresis lab. Female apheresis donors suffering a higher incidence rate of adverse events in comparison to the male apheresis donors have been reported by Tomita et al [7]. However, present study did not report incidence of any adverse events in all 18 female donors who underwent plateletpheresis procedures which may be a chance occurrence only.…”

Section: Discussioncontrasting

confidence: 59%

Adverse Events During Apheresis Procedures: Audit at a Tertiary Hospital

Dogra

Fulzele

Rout

et al. 2016

Indian J Hematol Blood Transfus

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Apheretic platelets are better quality blood components which reduce donor exposure and chances of TTIs to transfusion recipients when compared to the whole blood derived components. Though safe, these apheretic donations are associated with donor adverse events. We evaluated the incidence of such adverse events associated with the modern apheresis procedures that would provide an insight as well as help formulating preventive steps to avoid frequent occurrences of such events. This prospective audit-based observational study was conducted over 1 year. Donors for plateletpheresis were selected as per the standard operating procedure of the Apheresis Lab. The apheresis procedures were done on the MCS? (Haemonetics Corp.), Trima Accel (Terumo BCT) and COM.TEC (Fresenius Kabi AG). 1740 apheresis procedures were performed, out of which 1708 were plateletpheresis and 32 therapeutic plasma exchange (TPE) procedures for 7 patients. A total of 102 adverse events were noted; of which, 80 (78.43 %) events were associated with donors, 15 (14.71 %) were owed to equipment related problems and 7 (6.86 %) were technical aberrations. All the events associated with donors were mild. No adverse events were reported with any of the 32 TPEs. Apheresis procedures are associated with adverse events which can be reduced by meticulous donor-vigilance, superior training modules for the technical personnel and continued supervision of experienced transfusion medicine specialists. Continued efforts towards making the donor's experience with apheresis more pleasant give a forward thrust to the noble vision of preparing a voluntary apheresis donor pool in India.

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Section: Discussioncontrasting

confidence: 59%

Adverse Events During Apheresis Procedures: Audit at a Tertiary Hospital

Dogra

Fulzele

Rout

et al. 2016

Indian J Hematol Blood Transfus

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show abstract

“…Overall, evidence in the literature suggests that the frequency of reactions to apheresis donation is less than that seen in whole blood donation. 7,8 The adverse events during the process of plateletpheresis have been broadly divided into: 5,6,8 • Venipuncture related • Syncope/sweating/faintness • Citrate reactions Pain at the site of venipuncture was noted to be more common because the same vein in one arm is used for inflow and return, resulting in trauma and hematoma to the vein. Citrate is used as primary anticoagulant in donor apheresis procedures.…”

Section: Resultsmentioning

confidence: 99%

“…Tomita et al noted that hypocalcemia may be involved in the onset of vasovagal reactions in apheresis donors. 6 Hypovolemia and vasovagal reactions are treated similarly. The procedure should be temporarily paused and fluid infusion should be started.…”

Section: Resultsmentioning

confidence: 99%

Adverse donor reaction during and after plateletpheresis in a tertiary care centre

et al. 2017

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Background: Plateletpheresis is the process of collecting platelets, a component of blood involved in blood clotting. The term specifically refers to the method of collecting the platelets, which is performed by a device used in blood donation that separate the platelets and return other portion of blood to the donor. Platelet transfusion can be a life-saving procedure in preventing and treating serious complications from bleeding and haemorrhage in patients having disorders manifesting as thrombocytopenia like in dengue patients, ITP, aplastic anemia, and patients undergoing chemotherapy for leukaemia. In this study, our goal was to retrospectively analyse the adverse reactions occurred during and immediately after plateletpheresis donations.Methods: From January 2015 to October 2016, a total of 66 plateletpheresis procedures were performed in department of transfusion medicine, GMC Jammu, Jammu and Kashmir, India which is a tertiary care hospital.Results: Total 66 procedures were performed during our study period from which, four (6.06%) adverse events were recorded. Out of these four, two (50%) donors suffered from tingling sensation, one (25%) suffered from nausea and vomiting and One (25%) from haematoma formation.Conclusions: In Conclusion, the result of our 22-month study survey document that apheresis procedures performed on cell separators are safe procedures with the low incidence of adverse reactions.

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“…Some reports did not assess donors under 17 years of age, because they primarily analyzed allogeneic donors [2,4,6,7]. Previous studies demonstrated the safety of autologous blood donation for pediatric cardiac surgery (n = 80) [13] and homologous donation from high school students [17], and the risk of VVR was reported to be higher in younger autologous or homologous blood donors [2,3,11,15]. Our data revealed that the patients most susceptible to developing VVR were 10-13 years old, followed by those aged 14-17 years.…”

Section: Discussionmentioning

confidence: 99%

Predictors of vasovagal reactions during preoperative autologous blood donation: a single-institution analysis

Nishimori

Fujii

et al. 2017

Int J Hematol

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Studies examining risk factors associated with vasovagal reactions (VVRs) during autologous blood donations, especially in younger subjects, have been limited. The aim of the present study was to define risk factors for VVRs during preoperative autologous blood donation in patients, including those younger than 18 years old. We retrospectively analyzed 4,192 autologous, preoperative blood donations between 2007 and 2015 at Okayama University Hospital. Eighty-seven (2.08%) of the patients experienced VVRs. VVRs occurred approximately three times as often in patients 0-17 years old (16/320, 5.0%) than in patients 18 years and older (71/3,872, 1.8%). In particular, VVRs occurred more frequently in those 10-13 years old, and decreased with older age (P = 0.006). In a univariate analysis, younger age, lower body mass index, lower systolic blood pressure, lower body weight, lower total blood volume, female gender, first-time collection, and higher heart rate were associated with a higher incidence of VVRs. In a multivariate analysis, lower systolic blood pressure (P < 0.001), higher heart rate (P = 0.007), and first-time collection (P = 0.015), remained independent predictors of VVRs. These results emphasize the need for careful attention during blood collection. Keywords: Autologous blood donation, vasovagal reactions 3 IntroducitonAutologous blood donation is widely used for preoperative blood preparation to reduce exposure to allogeneic blood [1]. Autologous and allogeneic blood donors occasionally experience adverse reactions during or after blood withdrawal, such as weakness, pallor, nausea, sweating, and fainting [2,3]. These symptoms are generally called "vasovagal reactions" (VVRs) [2,4]. However, the pathophysiology of VVRs is not yet completely understood [5]. Although risk factors for VVRs have been analyzed mainly in healthy allogeneic donors or peripheral blood stem cell donors [2,4,[6][7][8], reports describing patients undergoing autologous collection have been limited. In particular, there are few data concerning patients younger than 16-18 years old. In the present study, we analyzed the risk factors for VVRs during autologous donation in patients, including those younger than 18 years old, at a single institution. Materials and methodsWe retrospectively collected medical information from 4,192 patients (groups I + II) who underwent autologous Patients were screened for vital signs, height, body weight, and complete blood count. Enrolled patients underwent whole blood phlebotomy in a designated room: blood volumes did not exceed 400 mL, or [body weight]/50 × 400 mL if the patient's body weight was less than 50 kg. All collections were conducted by a physician and nurse from the Department of Transfusion Medicine at Okayama University Hospital. An 18-gauge needle was inserted into an antecubital vein or a large forearm vein of each patient, and autologous blood was collected using a negative pressure blood drawing device (Hemoquick; Terumo, Tokyo, Japan). After phlebotomy, the patients were adm...

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Vasovagal reactions in apheresis donors

Cited by 56 publications

References 13 publications

Adverse Events During Apheresis Procedures: Audit at a Tertiary Hospital

Adverse Events During Apheresis Procedures: Audit at a Tertiary Hospital

Adverse donor reaction during and after plateletpheresis in a tertiary care centre

Predictors of vasovagal reactions during preoperative autologous blood donation: a single-institution analysis

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