VATS anatomic resections for lung cancer: insights from the Italian VATS Group

Divisi, Duilio; Gabriele, Francesca; Bertolaccini, Luca; Barone, Mirko; Procaccini, Luca; Zaccagna, Gino; Crisci, Roberto

doi:10.21037/shc.2017.11.02

Cited by 2 publications

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“…Our study, where a 2.5 cutoff of the SUVmax has been used to establish malignancy and has showed a relationship between FDG uptake and histopathology of the tumor; in fact, the SUVmax was significantly higher in squamous cell carcinomas compared to adenocarcinomas. This result is in agreement with our previous experience [11], in which a significant difference (p = 0.013), considering only the squamous carcinoma and invasive adenocarcinoma, was noted. The explanation can be sought in a greater expression of glucose transporter type 1 (GLUT-1) in squamous cell carcinomas than adenocarcinomas, as widely demonstrated in the literature [21][22][23][24].…”

Section: Discussionsupporting

confidence: 93%

“…The intensity of FDG uptake of the primary tumor is highly correlated with disease recurrence and survival in NSCLC patients [10]. The possible implication of SUVmax to distinguish between different histological types of lung cancer (squamous cell carcinoma or adenocarcinoma) has not yet been properly studied, though pulmonary squamous cell carcinoma displays a higher glucose transporter type 1 (GLUT-1) expression and F-FDG uptake than adenocarcinoma [11]. Moreover, whether histological subtypes of adenocarcinoma also differ in F-FDG uptake is still not clear, and there is no evidence that clarifies if tumor size had a role in varying the degree of SUVmax absorption between the different types of lung cancer.…”

Section: Introductionmentioning

confidence: 99%

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Is It Possible to Establish a Reliable Correlation between Maximum Standardized Uptake Value of 18-Fluorine Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography and Histological Types of Non-Small Cell Lung Cancer? Analysis of the Italian VATS Group Database

et al. 2021

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Background. Although positron emission tomography/computed tomography, often integrated with 2-deoxy-2-[fluorine-18] fluorine-D-glucose (18F-FDG-PET/CT), is fundamental in the assessment of lung cancer, the relationship between metabolic avidity of different histotypes and maximum standardized uptake value (SUVmax) has not yet been thoroughly investigated. The aim of the study is to establish a reliable correlation between Suvmax and histology in non-small cell lung cancer (NSCLC), in order to facilitate patient management. Methods. We retrospectively assessed the data about lung cancer patients entered in the Italian Registry of VATS Group from January 2014 to October 2019, after establishing the eligibility criteria of the study. In total, 8139 patients undergoing VATS lobectomy were enrolled: 3260 females and 4879 males. The relationship between SUVmax and tumor size was also analyzed. Results. The mean values of SUVmax in the most frequent types of lung cancer were as follows: a) 4.88 ± 3.82 for preinvasive adenocarcinoma; b) 5.49 ± 4.10 for minimally invasive adenocarcinoma; c) 5.87 ± 4.18 for invasive adenocarcinoma; and d) 8.85 ± 6.70 for squamous cell carcinoma. Processing these data, we displayed a statistically difference (p < 0.000001) of FDG avidity between adenocarcinoma and squamous cell carcinoma. Moreover, by classifying patients into five groups based on tumor diameter and after evaluating the SUVmax value for each group, we noted a statistical correlation (p < 0.000001) between size and FDG uptake, also confirmed by the post hoc analysis. Conclusions. There is a correlation between SUVmax, histopathology outcomes and tumor size in NSCLC. Further clinical trials should be performed in order to confirm our data.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Is It Possible to Establish a Reliable Correlation between Maximum Standardized Uptake Value of 18-Fluorine Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography and Histological Types of Non-Small Cell Lung Cancer? Analysis of the Italian VATS Group Database

et al. 2021

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“…Thoracoscopic lobectomy has steadfastly become standard of care for resection of NSCLC at most academic institutions. 72,73 According to studies of the STS GTSD, 47 to 61% of lobectomies are performed using thoracoscopic techniques in the United States. 24,27 However, this is likely due to the fact that general thoracic-trained surgeons are performing the majority of these operations.…”

Section: Training Utilization and Adoption Of Vats Lobectomymentioning

confidence: 99%

VATS and Minimally Invasive Resection in Early-Stage NSCLC

Salfity

Tong

2020

Semin Respir Crit Care Med

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Lung carcinoma widely affects men and women in the sixth and seventh decades of life. Thorough workup with radiographic imaging, pathologic diagnosis, and cardiopulmonary functional assessment is key to successful treatment. Accurate staging is essential for both assessing prognosis and directing therapy. Early-stage lung cancer is most often treated with anatomic lobectomy; locally advanced cancers may require induction or adjuvant therapies. Any nonnodal metastases will require definitive systemic therapy. Traditionally, surgery was performed with a posterolateral thoracotomy incision, division of the hilar vessels, removal of affected lung parenchyma, and a complete mediastinal and hilar lymph node dissection for accurate pathologic staging. In recent years, however, video-assisted thoracoscopic (VATS) or other minimally invasive approaches have emerged as the standard of care for early-stage disease. Compared with standard thoracotomy, VATS lobectomy offers improved postoperative outcomes as well as potential survival benefit. Thoracoscopic lobectomy is also cost-effective. This article focuses on the technique, outcomes, adaptation, and evolution of thoracoscopic lobectomy and other minimally invasive techniques in the treatment of lung cancer.

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VATS anatomic resections for lung cancer: insights from the Italian VATS Group

Cited by 2 publications

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Is It Possible to Establish a Reliable Correlation between Maximum Standardized Uptake Value of 18-Fluorine Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography and Histological Types of Non-Small Cell Lung Cancer? Analysis of the Italian VATS Group Database

Is It Possible to Establish a Reliable Correlation between Maximum Standardized Uptake Value of 18-Fluorine Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography and Histological Types of Non-Small Cell Lung Cancer? Analysis of the Italian VATS Group Database

VATS and Minimally Invasive Resection in Early-Stage NSCLC

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