2024
DOI: 10.1101/2024.06.05.597540
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VCAb: A web-tool for structure-guided antibody engineering

Dongjun Guo,
Joseph Chi-Fung Ng,
Deborah K. Dunn-Walters
et al.

Abstract: Effective responses against different immune challenges require secretion of antibodies with various isotypes performing specific effector functions. Structural information on these isotypes is essential to engineer antibodies with desired physico-chemical features of their antigen-binding properties, and optimal stability and developability as potential therapeutic antibodies.In silicomutational scanning profiles on antibody structures would further pinpoint candidate mutations for enhancing antibody stabilit… Show more

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