VCAb: A web-tool for structure-guided antibody engineering
Dongjun Guo,
Joseph Chi-Fung Ng,
Deborah K. Dunn-Walters
et al.
Abstract:Effective responses against different immune challenges require secretion of antibodies with various isotypes performing specific effector functions. Structural information on these isotypes is essential to engineer antibodies with desired physico-chemical features of their antigen-binding properties, and optimal stability and developability as potential therapeutic antibodies.In silicomutational scanning profiles on antibody structures would further pinpoint candidate mutations for enhancing antibody stabilit… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.