VCSEL-based oxygen spectroscopy for structural analysis of pharmaceutical solids

Svensson, Tomas; Andersson, Mats; Rippe, Lars; Svanberg, Sune; Andersson‐Engels, Stefan; Johansson, Jonas; Folestad, Staffan

doi:10.1007/s00340-007-2901-6

Cited by 76 publications

(67 citation statements)

References 30 publications

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“…It looks like the detection limit is an absorption of approximately 3 · 10 −5 , corresponding to an equivalent path length in air of around 1.5 mm. This result can be compared to the measurements presented in [29], where an Allan deviation showed a detection limit of 0.1 mm. These measurements used WMS, which greatly improve detection sensitivity, so it is not surprising that our measurements have lower sensitivity.…”

Section: Allan Deviationsupporting

confidence: 51%

Laser spectroscopy of gas confined in nanoporous materials

Svensson

Shen

2010

Applied Physics Letters

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We show that high-resolution laser spectroscopy can probe surface interactions of gas confined in nano-cavities of porous materials. We report on strong line broadening and unfamiliar lineshapes due to tight confinement, as well as signal enhancement due to multiple photon scattering. This new domain of laser spectroscopy constitute a challenge for the theory of collisions and spectroscopic lineshapes, and open for new ways of analyzing porous materials and processes taking place therein.Comment: 4 pages, 3 figures, partly presented orally at 7th International Conference on Tunable Diode Laser Spectroscopy (TDLS), July 2009 in Zermatt, Switzerland; Accepted for Applied Physics Letters (December 2009

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Section: Allan Deviationsupporting

confidence: 51%

Laser spectroscopy of gas confined in nanoporous materials

Svensson

Shen

2010

Applied Physics Letters

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“…The system used is described in detail in Ref. [15] and is based on a single-mode, vertical-cavity, surface-emitting laser diode, with an output power of P = 0.3 mW. The laser was tuned to the R9Q10 absorption line of O 2 at 760.654 nm and was then scanned over a frequency range of 40 GHz around the absorption line.…”

Section: Methodsmentioning

confidence: 99%

Wall-collision line broadening of molecular oxygen within nanoporous materials

Lewander

Andersson‐Engels

et al. 2011

Phys. Rev. A

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“…from the nano-to the milli-scale. However, other characterisation techniques have also been used (de Oliveira Jr et al, 2010;Nippolainen et al, 2010;Nordström et al, 2008b;Svensson et al, 2008;Svensson et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

The degree of compression of spherical granular solids controls the evolution of microstructure and bond probability during compaction

Nordström

Persson

Lazorova

et al. 2013

International Journal of Pharmaceutics

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The degree of compression of spherical granular solids controls the evolution of microstructure and bond probability during compaction. International Journal of Pharmaceutics AbstractThe effect of degree of compression on the evolution of tablet microstructure and bond probability during compression of granular solids has been studied.Microcrystalline cellulose pellets of low (about 11%) and of high (about 32%) porosity were used. Tablets were compacted at 100, 150 and 200 MPa applied pressures and the degree of compression and the tensile strength of the tablets determined. The tablets were subjected to mercury intrusion measurements and from the pore size distributions, a void diameter and the porosities of the voids and the intra-granular pores were calculated.The pore size distributions of the tablets had peaks associated with the voids and the intra-granular pores. The void and intra-granular porosities of the tablets were dependent on the original pellet porosity while the total tablet porosity was independent. The separation distance between pellets was generally lower for tablets formed from high porosity pellets and the void size related linearly to the degree of compression. Tensile strength of tablets was higher for tablets of high porosity pellets and a scaled tablet tensile strength related linearly to the degree of compression above a percolation threshold. In conclusion, the degree of compression controlled the separation distance and the probability of forming bonds between pellets in the tablet.3

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VCSEL-based oxygen spectroscopy for structural analysis of pharmaceutical solids

Cited by 76 publications

References 30 publications

Laser spectroscopy of gas confined in nanoporous materials

Laser spectroscopy of gas confined in nanoporous materials

Wall-collision line broadening of molecular oxygen within nanoporous materials

The degree of compression of spherical granular solids controls the evolution of microstructure and bond probability during compaction

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