VCSEL Optoelectronic Biosensor for Detection of Infectious Diseases

Huang, M.C.Y.; Mateus, C.F.R.; Foley, Jason; Beatty, Russell A.; Cunningham, Brian T.; Chang-Hasnain, Connie J.

doi:10.1109/lpt.2008.916947

Cited by 22 publications

(12 citation statements)

References 11 publications

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“…Taking into consideration these limitations, new methodologies and devices aimed at dengue diagnosis have been reported over the past decades . These biosensors can be classified based on the types of physical transduction mechanism exploited: piezoelectric (quartz crystal microbalance), − optical (surface plasmon resonance, , chemiluminescence, , magnetoresistance, fluorescence, − photonic crystals , ), and electrochemical. − For successful diagnosis of dengue infection in tropical and developing countries, a biosensor should gather the advantages of simplicity, economy, rapidity, and accuracy . These requirements have not been attained with any existing method, nor have any of the aforementioned studies demonstrated the detection of dengue infection in patient blood plasma.…”

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confidence: 99%

Serological Diagnosis of Dengue Infection in Blood Plasma Using Long-Range Surface Plasmon Waveguides

et al. 2014

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We present a compact, cost-effective, label-free, real-time biosensor based on long-range surface plasmon polariton (LRSPP) gold (Au) waveguides for the detection of dengue-specific immunoglobulin M (IgM) antibody, and we demonstrate detection in actual patient blood plasma samples. Two surface functionalization approaches are proposed and demonstrated: a dengue virus serotype 2 (DENV-2) functionalized surface to capture dengue-specific IgM antibody in blood plasma and the reverse, a blood plasma functionalized surface to capture DENV-2. The results obtained via these two surface functionalization approaches are comparable to, or of greater quality, than those collected by conventional IgM antibody capture enzyme linked immunosorbent assay (MAC-ELISA). Our second functionalization approach was found to minimize nonspecific binding, thus improving the sensitivity and accuracy of the test. We also demonstrate reuse of the biosensors by regenerating the sensing surface down to the virus (or antibody) level or down to the bare Au.

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mentioning

confidence: 99%

Serological Diagnosis of Dengue Infection in Blood Plasma Using Long-Range Surface Plasmon Waveguides

et al. 2014

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“…为此, Brazaca 等 [72] 用聚丙烯生物脱离方法将核酸捕获探针固定在平行 1D 光子晶体谐振器传感器表面, 可去除 98%的残基, 用多种模式检测登革热病毒. Huang 等 [73] 基于光子晶体表面的感测能力, 发展了可调谐的垂直腔表面发射激光器(VCSEL), 用于登革热 IgG 抗体的检测, 尽管该方法比 ELISA 方法灵敏度高, 但仍有假阳性.…”

Section: 光子晶体生物传感器unclassified

Biosensing Technology for Dengue Virus Detection

Shi¹,

Xia²,

He³

et al. 2022

Acta Chimica Sinica

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Dengue virus is a single-stranded RNA virus transmitted by mosquitoes, belonging to the flaviviridae. Currently, there are no targeted antiviral drugs and effective virus vaccines of timely prevention. Due to the importance of clinical detection, new methods for detecting Dengue virus infection have emerged in recent years, trying to detect and control this infection early. This review mainly describes the biosensing technologies for the detection of Dengue virus related diagnostic markers, including optical, electrochemical, enzyme-linked immunosorbent assay and other biosensing methods, and comprehensively evaluates the sensitivity, accuracy, concentration range, detection limit and clinical application ability of different detection methods, so as to further improve the detection performance of these technologies, and to promote the development of this field. It will provide references for the early diagnosis of Dengue virus infection.

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“…Only one wavelength sweep is sufficient to test the optical properties of the common optical components. In the biosensor application, the spectral shift of the sensor's optical properties, such as transmittance or reflectance is measured [15,21]. The optical properties of the sample must be measured several times.…”

Section: Orrb Readermentioning

confidence: 99%

A Compact Tunable VCSEL and a Built-in Wavelength Meter for a Portable Optical Resonant Reflection Biosensor Reader

Ko¹,

Kim²,

Kim³

et al. 2010

Journal of the Optical Society of Korea

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This study reports a portable and precision photonic biosensor reader that can measure the concentration of a particular antigen using an optical resonant reflection biosensor (ORRB). To create a compact biosensor reader, a compact tunable vertical-cavity surface-emitting laser (VCSEL) and a compact built-in wavelength meter were manufactured. The wavelength stability and accuracy of the compact built-in wavelength meter were measured to be less than 0.02 nm and 0.06 nm, respectively. The tunable VCSEL emission wavelength was measured with the compact built-in wavelength meter, it has a fast sweep time (~ 10 seconds) and a wide tuning range (> 4 nm) that are sufficient for biosensor applications based on ORRB. The reflection spectrum of a plastic based ORRB chip was measured by the fabricated portable photonic biosensor reader using the VCSEL and wavelength meter. Although the reader is the size of a palmtop device, it could make a precise measurement of the peak wavelength on equal terms with a conventional bulky optical spectrometer.

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VCSEL Optoelectronic Biosensor for Detection of Infectious Diseases

Cited by 22 publications

References 11 publications

Serological Diagnosis of Dengue Infection in Blood Plasma Using Long-Range Surface Plasmon Waveguides

Serological Diagnosis of Dengue Infection in Blood Plasma Using Long-Range Surface Plasmon Waveguides

Biosensing Technology for Dengue Virus Detection

A Compact Tunable VCSEL and a Built-in Wavelength Meter for a Portable Optical Resonant Reflection Biosensor Reader

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