VDBP Gene Polymorphism in COPD

Soyyiğit, Şadan; Baykara, Onur; Buyru, Nur; Erk, Müzeyyen

doi:10.5455/medscience.2012.01.8040

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…Also, the genotype Gc2-2 was protective against COPD (11, 28). In American (41), Canadian (38) and Caucasian populations, Gc2 and Gc2-2 also showed as a protective factor for COPD (42). However, this observation has not been confirmed by a subsequent study (29).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Vitamin D, Vitamin D Binding Protein Gene Polymorphism with Oxidant – Antioxidant Profiles in Chronic Obstructive Pulmonary Disease

Al-Azzawi¹,

Ghoneim²,

Elmadbouh³

2017

Journal of Medical Biochemistry

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SummaryBackground: The aim was to evaluate the association of plasma 25-hydroxyvitamin D (25-OHD) and vitamin D binding protein (VDBP or Gc-globin) gene polymorphism with oxidant-antioxidant profiles in patients with chronic obstructive pulmonary disease (COPD), and their role as biomarker risk factors in susceptibility and severity of COPD. Methods: Eighty patients diagnosed with COPD (mild, moderate and severe according to lung function tests; FEV 1%) and 80 healthy controls were included in the study. Serum nitric oxide (NO) and lipid peroxide (LP), plasma reduced glutathione (RGSH), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) activity, 25-OHD and VDBP polymorphism were analyzed in all subjects. Results: COPD patients had significantly decreased serum NO, plasma SOD, RGSH, GSH-Px, CAT and 25-OHD versus controls, but had significantly increased serum LP. In COPD patients, 25-OHD levels were significantly lower (41.49± 13.65 ng/mL) versus controls, but more lower in severe COPD patients (30.54±9.09 ng/mL; sensitivity 79.2%; specificity 73.2%, p<0.001) versus mild and moderate COPD. VDBP genotypes frequencies were Gc1S-1S=23.8%, Gc1F-

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Section: Discussionmentioning

confidence: 99%

Evaluation of Vitamin D, Vitamin D Binding Protein Gene Polymorphism with Oxidant – Antioxidant Profiles in Chronic Obstructive Pulmonary Disease

Al-Azzawi¹,

Ghoneim²,

Elmadbouh³

2017

Journal of Medical Biochemistry

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“…Bu çalışmanın haricinde GC alellerinin akciğer kanseri ile ilişkisini gösteren bir çalışma bulunmadığı gibi, 1S ve 1F alellerinin çeşitli kanser türleri üzerindeki etkisi gösteren çalışma sayısı da kısıtlıdır. [22] Daha önce KOAH'lı hastalarda VDBP gen polimorfizmlerini incelemiş olduğumuz çalışmada, 1F ve 2 alelerinin KOAH'ın gelişimi veya engellenmesi ile ilişkisi olmadığını ancak 1S-1S genotipine sahip olmanın KOAH etyolojisi ile ilişkili olabileceğini gös-terdik, [23] ancak bu çalışmamızda akciğer kanseri ve GC polimorfizmleri arasında herhangi bir ilişki saptayamadık. Beyazlarda yapılan bir çalışmada 1S, 1F ve 2 alel frekanslarının sırasıyla 0.56, 0.16 ve 0.28 olduğu gösterilmiştir.…”

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Role of vitamin D binding protein (VDBP) gene polymorphisms in lung cancer

Baykara¹

2017

Turk Gogus Kalp Dama

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ÖZBul gu lar: Hastaların %32.4'ünde 1S-2, %28.6'sında 1F-1S, %28.6'sında 1S-1S, %7.8'inde 1F-2 ve %2.6'sında 1F-1F genotipi bulunurken kontrol grubunda genotip frekansı sırasıyla %28, %24, %36, %4 ve %8 idi (p= 0.35). Results:Of the patients, the genotype 1S-2 was found in 32.4%, 1F-1S in 28.6%, 1S-1S in 28.6%, 1F-2 in 7.8% and 1F-1F in 2.6%, while the genotype frequencies in control group were 28%, 24%, 36%, 4% and 8%, respectively (p= 0.35). So nuç: Conclusion:We did not detect any relationship between vitamin D binding protein gene polymorphisms and lung cancer.

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VDBP Gene Polymorphism in COPD

Abstract: Chronic obstructive pulmonary disease (COPD) is a disease which genetic and environmental factors play an important role in COPD development. VDBP (Vitamin

Cited by 2 publications

References 27 publications

Evaluation of Vitamin D, Vitamin D Binding Protein Gene Polymorphism with Oxidant – Antioxidant Profiles in Chronic Obstructive Pulmonary Disease

Evaluation of Vitamin D, Vitamin D Binding Protein Gene Polymorphism with Oxidant – Antioxidant Profiles in Chronic Obstructive Pulmonary Disease

Role of vitamin D binding protein (VDBP) gene polymorphisms in lung cancer

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