VDR and VDBP genes polymorphisms associated with susceptibility to tuberculosis in a Han Taiwanese population

Lee, Shih Wei; Chuang, Tsu‐Yi; Huang, Hsiu Han; Liu, Chi Wei; Kao, Ying-Jer; Wu, Lawrence Shih Hsin

doi:10.1016/j.jmii.2015.12.008

Cited by 42 publications

(25 citation statements)

References 30 publications

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“…Epidemiological studies have revealed that VDR gene polymorphism is significantly associated with an increased risk of PTB in Venezuela, Iran, Turkey, and Han Taiwanese populations . Molecular epidemiological studies have also revealed that VDR polymorphism is significantly associated with an increased risk of PTB in tribal population of Chhattisgarh and southeastern region of India .…”

Section: Discussionmentioning

confidence: 99%

Association of VDR gene polymorphisms and 22 bp deletions in the promoter region of TLR2Δ22 (‐196‐174) with increased risk of pulmonary tuberculosis: A case‐control study in tea garden communities of Assam

Devi

Mukherjee

Chelleng

et al. 2018

Clinical Laboratory Analysis

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Section: Discussionmentioning

confidence: 99%

Association of VDR gene polymorphisms and 22 bp deletions in the promoter region of TLR2Δ22 (‐196‐174) with increased risk of pulmonary tuberculosis: A case‐control study in tea garden communities of Assam

Devi

Mukherjee

Chelleng

et al. 2018

Clinical Laboratory Analysis

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“…In contrast, others studies described a significant association between VDR polymorphisms and risk to develop TB in Turkish (BsmI, p = .0006) (Ates et al., ), Gambian (TaqI, p = .01) (Bellamy et al., ), Chinese (FokI, p < .05) (Chen et al., ; Liu et al., ), Indian (Joshi et al., ) (BsmI, p < .002), Iranian (Banoei et al., ; Merza et al., ; Salimi, Farajian‐Mashhadi, Alavi‐Naini, Talebian, & Narooie‐Nejad, ) and Taiwanese (TaqI, p = .035; BsmI, p = .034) populations (Lee et al., ).…”

Section: Candidate Genes and The Risk Of Developing Tbmentioning

confidence: 93%

Current immunogenetic predisposition to tuberculosis in the Moroccan population

Qrafli

Najimi

Elaouad

et al. 2017

Int J Immunogenetics

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Tuberculosis (TB) is a serious infectious disease that kills approximately two million people per year, particularly in low- and middle-income countries. Numerous genetic epidemiology studies have been conducted of many ethnic groups worldwide and have highlighted the critical impact of the genetic environment on TB distribution. Many candidate genes associated with resistance or susceptibility to TB have been identified. In Morocco, where TB is still a major public health problem, various observations of clinical, microbiological and incidence distribution are heavily affected by genetic background and external environment. Morocco has almost the same clinical profile as do other North African countries, mainly the increase in more extrapulmonary than pulmonary forms of the diseases, when compared to European, Asian or American populations. In addition, a linkage analysis study that examined Moroccan TB patients identified a unique chromosome region that had a strong association with the risk of contracting TB. Other genes in the Moroccan population that were found to be associated seem to be involved predominantly in modulating the innate immunity. In this review, we appraise the major candidate genes that have been reported in Moroccan immunogenetic studies and discuss their updated role in TB, particularly during the first phase of the immune response to Mycobacterium tuberculosis (Mtb) infection.

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“…A recent study investigated four polymorphisms of restriction endonuclease sites for ApaI, TaqI, BsmI and FokI in VDR and of the three polymorphisms rs4588A/C/T (Thr420Lys), rs7041G/T (Asp416Glu) and rs4725C/T (Cys299Cys) in the vitamin D receptor binding protein ( VDBP ) in 198 TB patients and 170 healthy controls from a Han Taiwanese population. The TaqI, BsmI variants ( VDR ) and rs7041G/T (Asp416Glu) ( VDBP ) were significantly associated with susceptibility to TB . Although VDR polymorphisms were not associated with susceptibility to TB in an Iranian population, vitamin D deficiency was strongly related to TB susceptibility .…”

Section: Candidate Gene Studies In Tuberculosismentioning

confidence: 98%

Human genetic factors in tuberculosis: an update

Tong

Velavan

Thye

et al. 2017

Tropical Med Int Health

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Tuberculosis (TB) is a major threat to human health, especially in many developing countries. Human genetic variability has been recognised to be of great relevance in host responses to Mycobacterium tuberculosis infection and in regulating both the establishment and the progression of the disease. An increasing number of candidate gene and genome-wide association studies (GWAS) have focused on human genetic factors contributing to susceptibility or resistance to TB. To update previous reviews on human genetic factors in TB we searched the MEDLINE database and PubMed for articles from 1 January 2014 through 31 March 2017 and reviewed the role of human genetic variability in TB. Search terms applied in various combinations were 'tuberculosis', 'human genetics', 'candidate gene studies', 'genome-wide association studies' and 'Mycobacterium tuberculosis'. Articles in English retrieved and relevant references cited in these articles were reviewed. Abstracts and reports from meetings were also included. This review provides a recent summary of associations of polymorphisms of human genes with susceptibility/resistance to TB.

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VDR and VDBP genes polymorphisms associated with susceptibility to tuberculosis in a Han Taiwanese population

Abstract: The polymorphisms in the VDR and VDBP genes appeared to be responsible for host susceptibility to human TB in a Taiwanese population.

Cited by 42 publications

References 30 publications

Association of VDR gene polymorphisms and 22 bp deletions in the promoter region of TLR2Δ22 (‐196‐174) with increased risk of pulmonary tuberculosis: A case‐control study in tea garden communities of Assam

Association of VDR gene polymorphisms and 22 bp deletions in the promoter region of TLR2Δ22 (‐196‐174) with increased risk of pulmonary tuberculosis: A case‐control study in tea garden communities of Assam

Current immunogenetic predisposition to tuberculosis in the Moroccan population

Human genetic factors in tuberculosis: an update

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