Vector-borne pathogens in dogs and red foxes from the federal state of Brandenburg, Germany

Liesner, Jana M.; Krücken, Jürgen; Schaper, Roland; Pachnicke, Stefan; Kohn, Barbara; Müller, Elisabeth; Schulze, Christoph; Samson‐Himmelstjerna, Georg von

doi:10.1016/j.vetpar.2016.05.012

Cited by 33 publications

(23 citation statements)

References 57 publications

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“…repens sequences deposited in GenBank [ 6 ]. Similar ITS-1 sequences have been recently identified in samples obtained from humans and dogs that acquired their infection in Europe [ 23 , 25 ]. In these cases, the ITS-2 sequence from the same sample was identical to typical D .…”

Section: Introductionsupporting

confidence: 57%

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The Mitochondrial Genomes of the Zoonotic Canine Filarial Parasites Dirofilaria (Nochtiella) repens and Candidatus Dirofilaria (Nochtiella) Honkongensis Provide Evidence for Presence of Cryptic Species

et al. 2016

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BackgroundCutaneous dirofilariosis is a canine mosquito-borne zoonosis that can cause larva migrans disease in humans. Dirofilaria repens is considered an emerging pathogen occurring with high prevalence in Mediterranean areas and many parts of tropical Asia. In Hong Kong, a second species, Candidatus Dirofilaria hongkongensis, has been reported. The present study aimed to compare mitochondrial genomes from these parasites and to obtain population genetic information.Methods and FindingsComplete mitochondrial genomes were obtained by PCR and Sanger sequencing or ILLUMINA sequencing for four worms. Cytochrome oxidase subunit 1 sequences identified three as D. repens (all from Europe) and one as C. D. hongkongensis (from India). Mitochondrial genomes have the same organization as in other spirurid nematodes but a higher preference for thymine in the coding strand. Phylogenetic analysis was in contradiction to current taxonomy of the Onchocercidae but in agreement with a recent multi-locus phylogenetic analysis using both mitochondrial and nuclear markers. D. repens and C. D. hongkongensis sequences clustered together and were the common sister group to Dirofilaria immitis. Analysis of a 2.5 kb mitochondrial genome fragment from macrofilaria or canine blood samples from Europe (42), Thailand (2), India (1) and Vietnam (1) revealed only small genetic differences in the D. repens samples including all European and the Vietnam sample. The Indian C. D. hongkongensis and the two Thai samples formed separate clusters and differences were comparatively large.ConclusionGenetic differences between Dirofilaria spp. causing cutaneous disease can be considerable whereas D. repens itself was genetically quite homogenous. C. D. hongkongensis was identified for the first time from the Indian subcontinent. The full mitochondrial genome sequence strengthens the hypothesis that it represents an independent species and the Thai samples might represent another cryptic species, Candidatus Dirofilaria sp. ‘Thailand II’, or a quite divergent population of C. D. hongkongensis.

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Section: Introductionsupporting

confidence: 57%

“…However, a large survey testing more than 1000 dogs and nearly 200 foxes from Brandenburg did not identify any additional autochthonous cases of D . repens infection [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

The Mitochondrial Genomes of the Zoonotic Canine Filarial Parasites Dirofilaria (Nochtiella) repens and Candidatus Dirofilaria (Nochtiella) Honkongensis Provide Evidence for Presence of Cryptic Species

et al. 2016

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“…glareolus ) and Microtus ( M. arvalis, M. agrestis, M. minutus ) [20] , [21] , [22] , [42] , [55] . It has been also detected in other mammals such as wild boar, bears, badgers, chamois and mouflons [56] , hedgehogs [57] and dogs [58] , [59] , [60] , [61] ( Fig. 1 ).…”

Section: Epidemiologymentioning

confidence: 91%

‘ Candidatus Neoehrlichia mikurensis’ in Europe

Portillo

Santibáñez

Palomar

et al. 2018

New Microbes and New Infections

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‘Candidatus Neoehrlichia mikurensis’ is an uncultured emerging bacterium that is provisionally included in the family Anaplasmataceae. In Europe, it is transmitted by Ixodes ricinus ticks. Rodents are the reservoirs. It is widely distributed in mammals (both wild and domestic) and birds. It causes an inflammatory disease in humans with underlying diseases, but the microorganism also affects immunocompetent individuals in which asymptomatic infection has been recognized. A high degree of suspicion and the use of molecular tools are needed for the correct diagnosis. Efforts to cultivate it and to investigate its pathogenesis should be a priority.

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“…There is no evidence of pathogenicity in other domestic animal species. Recently, the presence of NM in samples of dogs' blood was detected in Brandenburg, northern Germany; in 3 from 1,023 samples [62], but for now, the role of NM in disease development in companion animals remains unclear yet [56].…”

Section: Tick-borne Diseases In Urban and Peri-urban Areas Mean A Rismentioning

confidence: 99%

The role of companion animals in the environmental circulation of tick-borne bacterial pathogens

Skotarczak¹

2018

Ann Agric Environ Med.

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Ticks are known as vectors of a wide range of pathogens of medical and veterinary importance; some of them of zoonotic concern constitute a hazard for the emergence of tick-borne diseases shared between humans and domestic animals and becoming a part of the 'One Health' concept. Canine and feline tick-borne diseases have emerged in recent years, performing an extensive geographic distribution and enlarged global prevalence. The present review focuses on the recent epidemiological studies on the emergence of tick-borne bacterial pathogens in dogs and cats, and the discussion whether pet ownership increases the risk of tick-borne diseases. A lot of data provide confirmation that dogs and cats themselves may substantially contribute to the circulation of the ticks and tick-borne bacterial pathogens in the environment. Molecular diagnostics of tick-borne pathogens infections generates a lot of problems like the choice of molecular methods and molecular markers for the detection of bacterial genomic DNA, but play an important role in the diagnosis of infections. The study provides some insight into molecular diagnostic techniques and new potentially recognized bacterial pathogens of this group. Protecting human and companion animal health from vector-borne infections requires controlling vector populations, containing development of novel, practicable strategies that will limit vectors and transmission of vector-borne disease pathogens.

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Vector-borne pathogens in dogs and red foxes from the federal state of Brandenburg, Germany

Cited by 33 publications

References 57 publications

The Mitochondrial Genomes of the Zoonotic Canine Filarial Parasites Dirofilaria (Nochtiella) repens and Candidatus Dirofilaria (Nochtiella) Honkongensis Provide Evidence for Presence of Cryptic Species

The Mitochondrial Genomes of the Zoonotic Canine Filarial Parasites Dirofilaria (Nochtiella) repens and Candidatus Dirofilaria (Nochtiella) Honkongensis Provide Evidence for Presence of Cryptic Species

‘ Candidatus Neoehrlichia mikurensis’ in Europe

The role of companion animals in the environmental circulation of tick-borne bacterial pathogens

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