Vegetable Oil Enriched with Phytosterol Ester and the Degree of Serum Cholesterol Lowering Effect in Healthy Subjects

Seki, Shinji; Abe, Tatsuichirou; Hidaka, Ichirou; Kojima, Keiichi; Yoshino, Hisako; Aoyama, Toyohiko; Okazaki, Mitsuko; Kondo, Kazuo

doi:10.5650/jos.52.285

Cited by 7 publications

(1 citation statement)

References 40 publications

(32 reference statements)

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“…In seven (Blair et al, 2000;Gonzales et al, 2007;Homma et al, 2003, treatment arms 1 and 2; Maki et al, 2001, treatment arm 1; Niittynen et al, 2007;Nguyen et al, 1999, treatment arm 1) out of 17 treatment arms in which the earliest LDL-cholesterol measurement was made after two weeks of the intervention, the maximum LDL-cholesterol lowering effect was already attained after 2 weeks of the intervention; in another six (Hallikainen and Uusitupa, 1999, treatment arms 1 and 2; Maki et al, 2001, treatment arm 2; Nguyen et al, 1999, treatment arms 2 and 3; Seki et al, 2003a) of these 17 treatment arms most of the reduction was already achieved after two weeks. In the four remaining studies (Matvienko et al, 2002;Deveraj et al, 2004;Saito et al, 2006;Seki et al, 2003b) it took longer than two weeks before the maximum reduction was reached.…”

Section: Minimum Duration For Effect Of Plant Sterols/stanolsmentioning

confidence: 99%

Scientific Opinion on the substantiation of a health claim related to 3 g/day plant sterols/stanols and lowering blood LDL-cholesterol and reduced risk of (coronary) heart disease pursuant to Article 19 of Regulation (EC) No 1924/2006

Products¹

2012

EFSA Journal

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Following an application from Unilever PLC and Unilever NV, submitted pursuant to Article 19 of Regulation (EC) No 1924/2006 via the Competent Authority of the United Kingdom, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of an application to modify the conditions of use of an authorised Article 14 claim related to 1.5 – 3.0 g plant sterols/stanols per day and lowering blood LDL‐cholesterol by 7 – 12 % and reduced risk of (coronary) heart disease. The applicant has further requested that the minimum duration to obtain the effect be one to two weeks. The applicant provided a published systematic review and meta‐analysis that evaluated the comparative efficacy of plant sterols and plant stanols for lowering blood LDL‐cholesterol in healthy and hypercholesterolaemic subjects and an unpublished meta‐analysis on 27 randomised controlled human studies on the LDL‐lowering efficacy at a dose range between 2.6 and 3.4 g per day. On the basis of the data presented, the Panel concludes that plant sterols and stanol esters at daily intakes ranging from 1.5 to 3.0 g plant sterols/stanols in matrices approved by Regulation (EC) No 376/2010 (yellow fat spreads, dairy products, mayonnaise and salad dressings) have a similar efficacy on blood LDL‐cholesterol lowering, that plant sterols and stanol esters at a daily intake of 3 g (range 2.6 g to 3.4 g) plant sterols/stanols in matrices approved by Regulation (EC) No 376/2010 lower LDL‐cholesterol by 11.3 % (95 % CI: 10.0 – 12.5), and that the minimum duration required to achieve the maximum effect of plant sterols and stanols on LDL‐cholesterol lowering is two to three weeks.

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