VEGF-634G &gt; C (rs2010963) Gene Polymorphism and High Risk of Breast Cancer in the Northwest of Iran

Maghsoodi, Maral Salek; Khosroshahi, Negin Sadi; Beilankouhi, Elmira Aboutalebi Vand; Valilo, Mohammad; Feizi, Mohammad Ali Hosseinpour

doi:10.1007/s40944-022-00648-7

Cited by 8 publications

(1 citation statement)

References 26 publications

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“…Environmental factors that increase the risk of BC include alcohol intake, consuming a diet containing saturated fat, exposure to ionizing radiation, and inactivity. Breast cancer has an autosomal dominant inheritance and its incidence is higher by about 10% in family members and firstdegree relatives (6)(7)(8)(9). Reactive oxygen species (ROS) are constantly produced in the human body where they play various roles.…”

Section: Introductionmentioning

confidence: 99%

The nuclear factor erythroid 2-related factor 2/p53 axis in breast cancer

Fakheri,

Sajadi,

Afrashteh

et al. 2023

Biochem. med. (Online)

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One of the most important factors involved in the response to oxidative stress (OS) is the nuclear factor erythroid 2-related factor 2 (Nrf2), which regulates the expression of components such as antioxidative stress proteins and enzymes. Under normal conditions, Kelch-like ECH-associated protein 1 (Keap1) keeps Nrf2 in the cytoplasm, thus preventing its translocation to the nucleus and inhibiting its role. It has been established that Nrf2 has a dual function; on the one hand, it promotes angiogenesis and cancer cell metastasis while causing resistance to drugs and chemotherapy. On the other hand, Nrf2 increases expression and proliferation of glutathione to protect cells against OS. p53 is a tumour suppressor that activates the apoptosis pathway in aging and cancer cells in addition to stimulating the glutaminolysis and antioxidant pathways. Cancer cells use the antioxidant ability of p53 against OS. Therefore, in the present study, we discussed function of Nrf2 and p53 in breast cancer (BC) cells to elucidate their role in protection or destruction of cancer cells as well as their drug resistance or antioxidant properties.

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Section: Introductionmentioning

confidence: 99%