VEGF Expression in Osteosarcoma Correlates with Vascular Permeability by Dynamic MRI

Hoang, Bang H.; Dyke, Jonathan P.; Koutcher, Jason A.; Huvos, Andrew G.; Mizobuchi, Hiroo; Mazza, Beth Anne; Görlick, Richard; Healey, John H.

doi:10.1097/01.blo.0000141492.52166.20

Cited by 26 publications

(18 citation statements)

References 29 publications

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“…Because VEGF is the principal mediator of vascular permeability, researchers have tried to correlate DCE-MRI parameters with levels of VEGF expression. In some reports, the MRI parameters correlated relatively well with VEGF expression, which was determined by immunohistologic staining (56)(57)(58). However, in many other reports, such a correlation was not observed (59)(60)(61).…”

Section: Non-radionuclide-based Imaging Of Vegf/vegfr Expressionmentioning

confidence: 88%

Multimodality Molecular Imaging of Tumor Angiogenesis

Cai

Chen²

2008

J Nucl Med

468

414

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Molecular imaging is a key component of 21st-century cancer management. The vascular endothelial growth factor (VEGF)/ VEGF receptor signaling pathway and integrin a v b 3 , a cell adhesion molecule, play pivotal roles in regulating tumor angiogenesis, the growth of new blood vessels. This review summarizes the current status of tumor angiogenesis imaging with SPECT, PET, molecular MRI, targeted ultrasound, and optical techniques. For integrin a v b 3 imaging, only nanoparticle-based probes, which truly target the tumor vasculature rather than tumor cells because of poor extravasation, are discussed. Once improvements in the in vivo stability, tumor-targeting efficacy, and pharmacokinetics of tumor angiogenesis imaging probes are made, translation to clinical applications will be critical for the maximum benefit of these novel agents. The future of tumor angiogenesis imaging lies in multimodality and nanoparticlebased approaches, imaging of protein-protein interactions, and quantitative molecular imaging. Combinations of multiple modalities can yield complementary information and offer synergistic advantages over any modality alone. Nanoparticles, possessing multifunctionality and enormous flexibility, can allow for the integration of therapeutic components, targeting ligands, and multimodality imaging labels into one entity, termed ''nanomedicine,'' for which the ideal target is tumor neovasculature. Quantitative imaging of tumor angiogenesis and protein-protein interactions that modulate angiogenesis will lead to more robust and effective monitoring of personalized molecular cancer therapy. Multidisciplinary approaches and cooperative efforts from many individuals, institutions, industries, and organizations are needed to quickly translate multimodality tumor angiogenesis imaging into multiple facets of cancer management. Not limited to cancer, these novel agents can also have broad applications for many other angiogenesis-related diseases.

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Section: Non-radionuclide-based Imaging Of Vegf/vegfr Expressionmentioning

confidence: 88%

Multimodality Molecular Imaging of Tumor Angiogenesis

Cai

Chen²

2008

J Nucl Med

468

414

View full text Add to dashboard Cite

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“…Dynamic contrast enhanced (DCE)-MRI has been used extensively to measure microvascular permeability in many human tumors, such as bone sarcomas [122], head-neck and prostate tumors [123], breast tumors [124], cerebral gliomas [125], and breast tumors [126]. DCE-MRI is a non-invasive, functional method to measure active changes in hemodynamic parameters occurring following treatment before macroscopic changes, such as decreases in tumor volume, become evident.…”

Section: Imaging the Tumor Microvasculaturementioning

confidence: 99%

Imaging hemodynamics

Jennings

Raghunand

Gillies

2008

Cancer Metastasis Rev

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Microvascular permeability is a pharmacologic indicator of tumor response to therapy, and it is expected that this biomarker will evolve into a clinical surrogate endpoint and be integrated into protocols for determining patient response to antiangiogenic or antivascular therapies. This review discusses the physiological context of vessel permeability in an imaging setting, how it is affected by active and passive transport mechanisms, and how it is described mathematically for both theoretical and complex dynamic microvessel membranes. Many research groups have established dynamic-enhanced imaging protocols for estimating this important parameter. This review discusses those imaging modalities, the advantages and disadvantages of each, and how they compare in terms of their ability to deliver information about therapy-associated changes in microvessel permeability in humans. Finally, this review discusses future directions and improvements needed in these areas.

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“…Perfusion imaging sequences are used for providing insight into the vascularity of a tumor and can be accomplished with a variety of pulse sequences, including DW sequences (31), unenhanced perfusion sequences (60,61), and the most commonly implemented dynamic contrastenhanced sequence (62)(63)(64)(65)(66)(67)(68)(69)(70)(71)(72)(73)(74)(75)(76)(77)(78)(79)(80). Perfusion imaging with dynamic contrast-enhanced MR imaging is the most popular technique at this time, since other techniques have not been well explored for musculoskeletal tumors.…”

Section: Perfusion Mr Imaging (Functional Technique)mentioning

confidence: 99%