2006
DOI: 10.1177/039463200601900405
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Vegf is Likely a Key Factor in the Link between Inflammation and Angiogenesis in Psoriasis: Results of an Immunohistochemical Study

Abstract: Psoriasis is a chronic skin disease, characterized by epidermal hyperplasia, inflammation, angiogenesis and vascular remodelling. An immunohistochemical study on fifteen cryosections of psoriatic skin was performed using antibodies against VEGF, HIFl-a, CD34, Factor VIII, MMP-2, MMP-9, TIMP-l and TIMP-2. Psoriatic skin showed a diffuse VEGF positive staining (13.15± 6.6), while no expression was observed in normal epidermis. No or faint HIF-la immunostaining was detected in healthy skin, while in psoriatic ski… Show more

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Cited by 72 publications
(65 citation statements)
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“…[17][18][19] The defective keratinocytes further activate synthesis and release of cytokines. This becomes a vicious cycle and ultimately results in epidermal hyperplasia.…”
Section: Discussionmentioning
confidence: 99%
“…[17][18][19] The defective keratinocytes further activate synthesis and release of cytokines. This becomes a vicious cycle and ultimately results in epidermal hyperplasia.…”
Section: Discussionmentioning
confidence: 99%
“…VEGF levels are increased in psoriatic plaques compared with normal skin (19,20), especially the VEGF 121 isoform, which causes vascular permeability (22,23). Moreover, the higher VEGF expression correlates with the clinical severity of psoriasis (76,77).…”
Section: Discussionmentioning
confidence: 99%
“…Psoriatic plaques contain increased levels of VEGF compared with normal skin (18)(19)(20). VEGF is a major proangiogenic factor involved in many inflammatory diseases (21).…”
mentioning
confidence: 99%
“…In general, pathogenesis of psoriasis presents as epithelial hyperplasia, Th1 cell-mediated inflammation, and angiogenesis (17)(18)(19)(20). Consequently, we hypothesized that expression of up-regulated proteins in the epithelium may occur in association with cellular defense or survival mechanisms.…”
Section: Discussionmentioning
confidence: 99%