2006
DOI: 10.1016/j.ijom.2005.09.006
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VEGF is up-regulated by hypoxic stimulation and related to tumour angiogenesis and severity of disease in oral squamous cell carcinoma: in vitro and in vivo studies

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Cited by 60 publications
(36 citation statements)
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“…In fact, some studies have found any correlation between VEGF expression and angiogenesis in oral dysplasia or carcinoma [6,[19][20][21][22]. while other reports have clearly demonstrated this correlation [5,9,11,12,16,[23][24][25]. This discrepancy could be explained by the fact that while other studies have utilized to stain microvessels pan-endothelial markers, such as CD31, CD34, and vWF-factor VIII, in this study, we have used CD105, a marker of highly proliferating endothelial cells.…”
Section: Discussionmentioning
confidence: 78%
“…In fact, some studies have found any correlation between VEGF expression and angiogenesis in oral dysplasia or carcinoma [6,[19][20][21][22]. while other reports have clearly demonstrated this correlation [5,9,11,12,16,[23][24][25]. This discrepancy could be explained by the fact that while other studies have utilized to stain microvessels pan-endothelial markers, such as CD31, CD34, and vWF-factor VIII, in this study, we have used CD105, a marker of highly proliferating endothelial cells.…”
Section: Discussionmentioning
confidence: 78%
“…In addition, the authors of that study noted a significant inverse association between the loss of IGFBP3 expression and overall, disease-specific and disease-free survival and they concluded that a low IGFBP3 expression is a predictor of poor prognosis in patients with SCC of the tongue. VEGF plays a key role in tumour angiogenesis and it has been identified in several malignancies, including HNSCC (23,24). The results of previous studies on VEGF expression and tumour angiogenesis and the association between the clinicopathological factors and prognosis in head and neck tumours, particularly in SCC of the larynx, are controversial (25,26).…”
Section: Discussionmentioning
confidence: 99%
“…In an earlier study, it was demonstrated that VEGF positivity was correlated with regional lymph nodal involvement and clinical stage. VEGF expression was oxygen dependent: when oxygen level decreased to 1 %, there was a 2.1-fold and nearly a 2.9-fold elevation of VEGF protein expression in OSCC [61]. VEGF-A and B are involved in angiogenesis, whereas VEGF-C and D promote lymphangiogenesis.…”
Section: Vegf In Osccmentioning
confidence: 99%