Vehicle Composition Influence on the Microneedle-Enhanced Transdermal Flux of Naltrexone Hydrochloride

Milewski, Mikolaj; Stinchcomb, Audra L.

doi:10.1007/s11095-010-0191-x

Cited by 38 publications

(64 citation statements)

References 43 publications

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“…Previously lidocaine formulation bypassing the SC epidermal layer was outlined, the viscoelastic properties in adapting a NaCMC/gel network hydrogel prevent slippage of the drug formulation when applied to the skin and the possibility of non-convective flow through the opened cavities of the skin from MN treatment (Milewski & Stinchcomb, 2011;Ghosh et al, 2013a). To try and exploit this potential, the main aim of the study is to combine the techniques in MN array and ultrasound technology as a pre-treatment to meet the definition of an ideal anaesthetic delivery method.…”

Section: Introductionmentioning

confidence: 99%

“…A major advantage is that an extended release is possible using this approach. A carbohydrate-based visceral hydrogel formulation was prepared as a model anaesthetic as this provides flexible properties and ability to encapsulate considerable amounts of liquid drug, lidocaine in this instance (Milewski & Stinchcomb, 2011), as discussed in the following section. Furthermore, the spreading behavior of the prepared formulation was studied and compared with the spreading behavior lidocaine solution as a Newtonian liquid.…”

Section: Introductionmentioning

confidence: 99%

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Lidocaine carboxymethylcellulose with gelatine co-polymer hydrogel delivery by combined microneedle and ultrasound

et al. 2014

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A study that combines microneedles (MNs) and sonophoresis pre-treatment was explored to determine their combined effects on percutaneous delivery of lidocaine from a polymeric hydrogel formulation. Varying ratios of carboxymethylcellulose and gelatine (NaCMC/gel ranges 1:1.60-1:2.66) loaded with lidocaine were prepared and characterized for zeta potential and particle size. Additionally, variations in the formulation drying techniques were explored during the formulation stage. Ex vivo permeation studies using Franz diffusion cells measured lidocaine permeation through porcine skin after pre-treatment with stainless steel MNs and 20 kHz sonophoresis for 5-and 10-min durations. A stable formulation was related to a lower gelatine mass ratio because of smaller mean particle sizes and high zeta potential. Lidocaine permeability in skin revealed some increases in permeability from combined MN and ultrasound pre-treatment studies. Furthermore, up to 4.8-fold increase in the combined application was observed compared with separate pre-treatments after 30 min. Sonophoresis pre-treatment alone showed insignificant enhancement in lidocaine permeation during the initial 2 h period. MN application increased permeability at a time of 0.5 h for up to ∼17 fold with an average up to 4 fold. The time required to reach therapeutic levels of lidocaine was decreased to less than 7 min. Overall, the attempted approach promises to be a viable alternative to conventional lidocaine delivery methods involving painful injections by hypodermic needles. The mass transfer effects were fairly enhanced and the lowest amount of lidocaine in skin was 99.7% of the delivered amount at a time of 3 h for lidocaine NaCMC/GEL 1:2.66 after low-frequency sonophoresis and MN treatment.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lidocaine carboxymethylcellulose with gelatine co-polymer hydrogel delivery by combined microneedle and ultrasound

et al. 2014

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“…A combined MN/nanoencapsulation approach has been reported for the intradermal delivery of a nanoencapsulated lipophilic model of a photosensitizer using dissolving MNs [11] and the in vitro transdermal delivery of a rhodamine B (Rh B) as a model medium-size dye using the poke and patch technique [10]. More effective exploitation of the approach, however, should be based on a better understanding of the variables controlling translocation of NPs through the aqueous MN-created channels, particularly those involved in in-skin drug release and the concentration gradient-driven diffusion of the released encapsulated species across hydrophilic, viable skin layers [20].…”

Section: Introductionmentioning

confidence: 99%

Microneedle/nanoencapsulation-mediated transdermal delivery: Mechanistic insights

Gomaa

Garland

McInnes

et al. 2014

European Journal of Pharmaceutics and Biopharmaceutics

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“…Therefore, NY exists as azo form (scheme 2) in the experimental conditions (BR buffer solution pH 6.0). NTX pK a values are 8.20 and 9.63 [57]. The first pK a corresponds to the dissociation of the protonated aliphatic nitrogen proton and the second to the dissociation of the phenolic proton.…”

Section: Full Papermentioning

confidence: 99%

Application of Glassy Carbon Electrode Modified with a Bilayer of Multiwalled Carbon Nanotube and Polypyrrole Doped with Nitrazine Yellow for Voltammetric Determination of Naltrexone

2011

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A new sensitive electrochemical sensor was fabricated based on a layer by layer process. In this process the glassy carbon electrode (GCE) is first coated by a thin film of multiwalled carbon nanotubes (MWCNTs). In the next step, the electropolymerization of pyrrole in the presence of Nitrazine Yellow (NY) as a dopant anion is performed on the surface of the MWCNTs precoated electrode. The electrochemical response characteristics of the modified electrode toward naltrexone (NTX) were studied by means of linear sweep voltammetry (LSV). A remarkable increase (~19 times) was observed in the anodic peak current of NTX on the surface of the modified electrode relative to the bare GCE. The effects of experimental parameters on the electrode response such as, drop size of the cast MWCNTs suspension, pH of the supporting electrolyte, accumulation conditions and the number of cycles in the electropolymerization process were investigated. Under the optimum conditions, the modified electrode showed a wide linear response to the concentration of NTX in the range of 4.0 10À5 mol L À1 with a detection limit of 12 nmol L À1. The prepared sensor exhibited high sensitivity, stability and good reproducibility for the determination of NTX. This sensor was successfully applied for the accurate determination of trace amounts of NTX in pharmaceutical and clinical preparations.

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Vehicle Composition Influence on the Microneedle-Enhanced Transdermal Flux of Naltrexone Hydrochloride

Abstract: Diffusion through the microchannel pathway seems to be donor viscosity-related and follows the relationship predicted by the Stokes-Einstein equation as shown by linear dependence of flux on diffusivity of NTX in donor solutions.

Cited by 38 publications

References 43 publications

Lidocaine carboxymethylcellulose with gelatine co-polymer hydrogel delivery by combined microneedle and ultrasound

Lidocaine carboxymethylcellulose with gelatine co-polymer hydrogel delivery by combined microneedle and ultrasound

Microneedle/nanoencapsulation-mediated transdermal delivery: Mechanistic insights

Application of Glassy Carbon Electrode Modified with a Bilayer of Multiwalled Carbon Nanotube and Polypyrrole Doped with Nitrazine Yellow for Voltammetric Determination of Naltrexone

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