<p>At present, typical reinforcement methods of box girders able to consider spatial effects are known as the amplification factor method, "panel element model" method, and the "spatial grid model" method. However, the differences between these methods have not been investigated.</p><p>In this paper, these methods are compared in terms of the full spatial resistances of box-girders, by evaluating the reinforcement results in an example. A surplus indicator in different directions in terms of the ultimate bearing capacity and normal section crack resistance is defined. The results show that in the mid-span section, the amplification factor method is prone to over-limiting the principal tensile stresses at the bottom panel near the web, and the other two methods have the good load-bearing capacity and crack resistance in all directions, but the reinforcement (especially for the spatial grid model method) is too conservative at the web and bottom panel.</p>