Venlafaxine Determination in Pharmaceutical Formulation and Serum by Ion-Selective Electrodes

Mansour, Marwa; El-Moety, Mona M. Abd; Kady, Ehab F El; Guindi, N M El; Schepdael, Ann Van; Aly, S. M. El-Moghazy

doi:10.2174/1381612824666180727112730

Cited by 3 publications

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“…Another study conducted by Mansour et al showed the encouraging future of the ion-selective electrodes to examine the VEN [ 38 ], particularly in pharmaceutical preparation and serum with no pretreatment. To sum up, these sensors are based on the utilization of ion association complexes of the VEN cation with silicotungstate (ST) and phosphotungstate (PT) counter anions as the ion exchange sites in a plasticized PVC matrix.…”

Section: Electrochemical Detection Of Venlafaxinementioning

confidence: 99%

“…Moreover, the soluble product of the ion pair and formation of the precipitation reaction resulting in the ion pair’s conductimetrical detection showed the high selectivity and accuracy of the electrodes (RSD < 1%) and their applicability for potentiometrically determining the VEN hydrochloride in pure solution or pharmaceutical procurement as well as in biological fluid (serum) with no interferences. Finally, technique validation showed the appropriateness of new electrodes in evaluating the venlafaxine hydrochloride quality [ 38 ].…”

Section: Electrochemical Detection Of Venlafaxinementioning

confidence: 99%

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Recent Advances in the Electrochemical Sensing of Venlafaxine: An Antidepressant Drug and Environmental Contaminant

Tajik

Beitollahi

Dourandish

et al. 2020

Sensors

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Venlafaxine (VEN), as one of the popular anti-depressants, is widely utilized for the treatment of major depressive disorder, panic disorder, as well as anxiety. This drug influences the chemicals in the brain, which may result in imbalance in depressed individuals. However, venlafaxine and its metabolites are contaminants in water. They have exerted an adverse influence on living organisms through their migration and transformation in various forms of adsorption, photolysis, hydrolysis, and biodegradation followed by the formation of various active compounds in the environment. Hence, it is crucial to determine VEN with low concentrations in high sensitivity, specificity, and reproducibility. Some analytical techniques have been practically designed to quantify VEN. However, electroanalytical procedures have been of interest due to the superior advantages in comparison to conventional techniques, because such methods feature rapidity, simplicity, sensitivity, and affordability. Therefore, this mini-review aims to present the electrochemical determination of VEN with diverse electrodes, such as carbon paste electrodes, glassy carbon electrodes, mercury-based electrodes, screen-printed electrodes, pencil graphite electrodes, and ion-selective electrodes.

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Section: Electrochemical Detection Of Venlafaxinementioning

confidence: 99%

Section: Electrochemical Detection Of Venlafaxinementioning

confidence: 99%

Recent Advances in the Electrochemical Sensing of Venlafaxine: An Antidepressant Drug and Environmental Contaminant

Tajik

Beitollahi

Dourandish

et al. 2020

Sensors

View full text Add to dashboard Cite

show abstract

A state-of-the-art review on the nanomaterial-based sensor for detection of venlafaxine

et al. 2022

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Potentiometric sensors for the determination of pharmaceutical drugs

et al. 2022

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Potentiometric sensors based on ion-selective membrane electrodes have continued to get great attention from the scientific community. These sensors have been employed in several applications including medicine, forensic analysis, environmental assessment, industry, agriculture, and pharmaceutical drug analysis. Indeed these sensors possess several advantages for example simple design, fabrication, and manipulation, rapid response time, good selectivity, applicability to colored and turbid solutions, and possible interfacing with automated and computerized systems. On the other hand, therapeutic drug monitoring and detection of pharmaceutical drugs in their pharmaceutical formulations and biological matrices are highly significant from a medical point of view especially for drugs with a narrow therapeutic index such as anticancer drugs which can cause fatal side effects for patients. Interestingly, potentiometric sensors have been broadly employed as one of the most important electrochemical approaches for pharmaceutical drug analysis. Moreover, the breakthroughs in potentiometric sensors based on ion-selective electrodes (ISEs) make them superior to the other reported methods for pharmaceutical drug analysis in terms of many performance parameters such as sensitivity, selectivity, low detection limit, and low cost. In this review, we try to offer a summary prologue to the applicability and merits of the potentiometric sensors that have been employed for pharmaceutical drug analysis emphasizing their application for the assay of pharmaceutical drugs in their dosage forms and the in-vivo assay of pharmaceutical drugs in different biological samples such as milk, water, plasma, and urine.

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Venlafaxine Determination in Pharmaceutical Formulation and Serum by Ion-Selective Electrodes

Cited by 3 publications

References 0 publications

Recent Advances in the Electrochemical Sensing of Venlafaxine: An Antidepressant Drug and Environmental Contaminant

Recent Advances in the Electrochemical Sensing of Venlafaxine: An Antidepressant Drug and Environmental Contaminant

A state-of-the-art review on the nanomaterial-based sensor for detection of venlafaxine

Potentiometric sensors for the determination of pharmaceutical drugs

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