Venlafaxine plus melatonin ameliorate reserpine-induced depression-like behavior in zebrafish

Tang, Yaqiu; Li, Zhuoran; Zhang, Shao-Zhi; Mi, Ping; Chen, Dongyan; Feng, Xisheng

doi:10.1016/j.ntt.2019.106835

Cited by 27 publications

(8 citation statements)

References 34 publications

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“…In order to improve screening efficiency and conduct high-throughput screening, we established reserpine-induced models on zebrafish. It has been reported in the literature that 20 and 40 mg/L reserpine did not cause significant acute behavioral effects, and locomotor ability was significantly reduced after 7 days, similar to the locomotor retardation observed in depression [30][31][32][33]. Based on this research, we found that when the concentration of reserpine was 10 mg/L, it could cause zebrafish to show reduced locomotor ability and exploratory behavior.…”

Section: Discussionsupporting

confidence: 83%

A Reliable High-Throughput Screening Model for Antidepressant

Zhang

Qiao

Liu

et al. 2021

IJMS

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Depression is the most frequent affective disorder and is the leading cause of disability worldwide. In order to screen antidepressants and explore molecular mechanisms, a variety of animal models were used in experiments, but there is no reliable high-throughput screening method. Zebrafish is a common model organism for mental illness such as depression. In our research, we established chronic unpredictable mild stress (CUMS) models in C57BL/6 mice and zebrafish; the similarities in behavior and pathology suggest that zebrafish can replace rodents as high-throughput screening organisms. Stress mice (ip., 1 mg/kg/d, 3 days) and zebrafish (10 mg/L, 20 min) were treated with reserpine. As a result, reserpine caused depression-like behavior in mice, which was consistent with the results of the CUMS mice model. Additionally, reserpine reduced the locomotor ability and exploratory behavior of zebrafish, which was consistent with the results of the CUMS zebrafish model. Further analysis of the metabolic differences showed that the reserpine-induced zebrafish depression model was similar to the reserpine mice model and the CUMS mice model in the tyrosine metabolism pathway. The above results showed that the reserpine-induced depression zebrafish model was similar to the CUMS model from phenotype to internal metabolic changes and can replace the CUMS model for antidepressants screening. Moreover, the results from this model were obtained in a short time, which can shorten the cycle of drug screening and achieve high-throughput screening. Therefore, we believe it is a reliable high-throughput screening model.

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Section: Discussionsupporting

confidence: 83%

A Reliable High-Throughput Screening Model for Antidepressant

Zhang

Qiao

Liu

et al. 2021

IJMS

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“…The normal function of the predator avoidance mechanism was disrupted after THCP exposure, as evidenced by the reduced avoidance behavior and thigmotaxis. Depressive-like behavior of zebrafish is generally reflected by reduced motor activity and exploratory behavior and increased freezing behavior [ 21 ]. In addition, it was reported that decreases in AChE activity could increase depression-like behaviors [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

“…The nAChRs of vertebrates are part of the cys-loop family of neurotransmitter-gated ion channels, including γ-aminobutyric acid (GABA), serotonin (5-HT) and glycine receptors [ 3 ]. GABA is the main inhibitory neurotransmitter in the central nervous system of vertebrates, produced by GABAergic neurons and released through synapses, and then endogenously activating GABA receptors to modulate neurotransmission [ 20 , 21 ]. 5-HT is the principal neurotransmitter for modulating various brain functions and psychiatric conditions such as depression and antisocial behavior [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Early-Stage High-Concentration Thiacloprid Exposure Induced Persistent Behavioral Alterations in Zebrafish

Xie

2022

IJERPH

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As a major neonicotinoid insecticide, thiacloprid (THCP) is frequently detected in aquatic environments worldwide due to its heavy use, posing potential threats to aquatic organisms. In this study, zebrafish (Danio rerio) embryos were exposed to THCP (1, 10, 100, 1000 and 10,000 μg/L) for 5 days and then recovered in THCP-free water for 20 days to investigate the effects of early-stage THCP exposure on the development, antioxidant defense, and neurotransmitter systems of zebrafish, and explore their recovery mechanism. The results show that THCP exposure induced developmental toxicity and oxidative stress in zebrafish. The hypoactivity, behavioral alterations (decreased avoidance and edge preference behaviors) and neurotoxicity were found throughout the exposure-recovery experiments. THCP exposure altered the expression of γ-aminobutyric acid (GABA)- and serotonin (5-HT)-related genes accompanied by the decrease in GABA and 5-HT contents. However, after recovery, GABA content returned to the control level, but 5-HT did not, indicating that only the serotonergic system was persistently disrupted. Overall, our results suggest that the disruption of the serotonergic system and oxidative stress may aggravate neurotoxicity and that the former was the main reason for the depressive-like behavior. This study could help to unravel the mechanisms of the behavioral alterations induced by early-stage THCP exposure in zebrafish.

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“…A similar effect was obtained after exposure to venlafaxine, a serotonin-norepinephrine reuptake inhibitor (SNRI). In the studies by Tang and colleagues [ 97 ], exposure to venlafaxine reversed the reserpine-induced depressive behavior in adult zebrafish, i.e., it increased exploratory activity (as well as an exploratory behavior) and reduced the frequency of irregular movement or freezing episodes in the NTT.…”

Section: Zebrafish In Neurological Studiesmentioning

confidence: 99%

Zebrafish as an Animal Model for Testing Agents with Antidepressant Potential

Lachowicz

Niedziałek

Rostkowska³

et al. 2021

Life

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Depression is a serious mental disease that, according to statistics, affects 320 million people worldwide. Additionally, a current situation related to the COVID-19 pandemic has led to a significant deterioration of mental health in people around the world. So far, rodents have been treated as basic animal models used in studies on this disease, but in recent years, Danio rerio has emerged as a new organism that might serve well in preclinical experiments. Zebrafish have a lot of advantages, such as a quick reproductive cycle, transparent body during the early developmental stages, high genetic and physiological homology to humans, and low costs of maintenance. Here, we discuss the potential of the zebrafish model to be used in behavioral studies focused on testing agents with antidepressant potential.

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Venlafaxine plus melatonin ameliorate reserpine-induced depression-like behavior in zebrafish

Cited by 27 publications

References 34 publications

A Reliable High-Throughput Screening Model for Antidepressant

A Reliable High-Throughput Screening Model for Antidepressant

Early-Stage High-Concentration Thiacloprid Exposure Induced Persistent Behavioral Alterations in Zebrafish

Zebrafish as an Animal Model for Testing Agents with Antidepressant Potential

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